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Clark, Graeme C. and Casewell, Nicholas R. and Elliott, Christopher T. and Harvey, Alan L. and Jamieson, Andrew G. and Strong, Peter N. and Turner, Andrew D. (2019) Friends or foes? Emerging impacts of biological toxins. Trends in Biochemical Sciences, 44 (4). pp. 365-379. ISSN 0968-0004

Malina, Tamás and Krecsák, László and Westerström, Alexander and Szemán-Nagy, Gábor and Gyémánt, Gyöngyi and M-Hamvas, Márta and Rowan, Edward G. and Harvey, Alan L. and Warrell, David A. and Pál, Balázs and Rusznák, Zoltán and Vasas, Gábor (2017) Individual variability of venom from the European adder (Vipera berus berus) from one locality in Eastern Hungary. Toxicon, 135. pp. 59-70. ISSN 1879-3150

Anthony, Nahoum G. and Baiget, Jessica and Berretta, Giacomo and Boyd, Marie and Breen, David and Edwards, Joanne and Gamble, Carly and Gray, Alexander I. and Harvey, Alan L. and Hatziieremia, Sophia and Ho, Ka Ho and Huggan, Judith K. and Lang, Stuart and Llona-Minguez, Sabin and Luo, Jia Lin and McIntosh, Kathryn and Paul, Andrew and Plevin, Robin J. and Robertson, Murray N. and Scott, Rebecca and Suckling, Colin J. and Sutcliffe, Oliver Brook and Young, Louise C. and MacKay, Simon P. (2017) Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers. Journal of Medicinal Chemistry, 60 (16). pp. 7043-7066. ISSN 0022-2623

Harvey, Alan (2017) Toxicon : Letter from the outgoing editor. Toxicon, 132. p. 18. ISSN 1879-3150

Harvey, Alan and Edrada-Ebel, Ruangelie and Quinn, Ronald J. (2015) The re-emergence of natural products for drug discovery in the genomics era. Nature Reviews Drug Discovery, 14. 111–129. ISSN 1474-1784

Harvey, Alan L. (2014) Toxins and drug discovery. Toxicon, 92. pp. 193-200. ISSN 1879-3150

Sánchez Calero, Janet and Young, Louise C. and Marrero Faz, Evangelina and L. Harvey, Alan (2014) Efecto inhibitorio de un extracto acuoso de las hojas de Allophylus cominia (L.) Sw sobre las proteínas tirosina fosfatasa 1B y dipeptidil peptidasa IV. Revista Cubana de Farmacia, 48 (4). pp. 672-683. ISSN 1561-2988

Marrero-Faz, Evangelina and Sánchez-Calero, Janet and Young, Louise and Harvey, Alan (2014) Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 13 (2). pp. 144-151.

Challal, Soura and Buenafe, Olivia Erin M and Queiroz, Emerson Ferreira and Maljevic, Snezana and Marcourt, Laurence and Bock, Merle and Kloeti, Werner and Dayrit, Fabian Millar and Harvey, Alan L and Lerche, Holger and Esguerra, Camila V and de Witte, Peter A M and Wolfender, Jean-Luc and Crawford, Alexander D (2014) Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. ACS Chemical Neuroscience, 5 (10). pp. 993-1004. ISSN 1948-7193

Dietrich, Daniel R. and von Aulock, Sonja and Marquardt, Hans and Blaauboer, Bas and Dekant, Wolfgang and Kehrer, James and Hengstler, Jan and Collier, Abby and Gori, Gio Batta and Pelkonen, Olavi and Lang, Florian and Nijkamp, Frans P. and Stemmer, Kerstin and Li, Albert and Savolainen, Kai and Wallace Hayes, A. and Gooderham, Nigel and Harvey, Alan and Barile, Frank A. (2013) Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Toxicon, 76. A1-A2. ISSN 1879-3150

Dietrich, Daniel R and von Aulock, Sonja and Marquardt, Hans and Blaauboer, Bas and Dekant, Wolfgang and Hengstler, Jan and Collier, Abby and Gori, Gio Batta and Pelkonen, Olavi and Lang, Florian and Nijkamp, Frans P and Stemmer, Kerstin and Li, Albert and Savolainen, Kai and Hayes, A Wallace and Gooderham, Nigel and Harvey, Alan (2013) Editorial : Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Regulatory Toxicology and Pharmacology, 67 (3). pp. 317-320.

Dietrich, Daniel R and von Aulock, Sonja and Marquardt, Hans and Blaauboer, Bas and Dekant, Wolfgang and Kehrer, James and Hengstler, Jan and Collier, Abby and Gori, Gio Batta and Pelkonen, Olavi and Lang, Florian and Nijkamp, Frans P and Stemmer, Kerstin and Li, Albert and Savolainen, Kai and Hayes, A Wallace and Gooderham, Nigel and Harvey, Alan (2013) Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Food and Chemical Toxicology, 62. A1-A4.

Dietrich, Daniel R and von Aulock, Sonja and Marquardt, Hans and Blaauboer, Bas and Dekant, Wolfgang and Kehrer, James and Hengstler, Jan and Collier, Abby and Gori, Gio Batta and Pelkonen, Olavi Pelkonen and Lang, Florian and Nijkamp, Frans P and Stemmer, Kerstin and Li, Albert and Savolainen, Kai and Hayes, A Wallace and Gooderham, Nigel and Harvey, Alan (2013) Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Toxicology in Vitro, 27 (7). pp. 2110-2114.

Dietrich, Daniel R and Aulock, Sonja von and Marquardt, Hans and Blaauboer, Bas and Dekant, Wolfgang and Kehrer, James and Hengstler, Jan and Collier, Abby and Gori, Gio Batta and Pelkonen, Olavi and Lang, Florian and Barile, Frank A and Nijkamp, Frans P and Stemmer, Kerstin and Li, Albert and Savolainen, Kai and Hayes, A Wallace and Gooderham, Nigel and Harvey, Alan (2013) Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Chemico-Biological Interactions, 205 (1). A1-A5. ISSN 0009-2797

Dietrich, Daniel and von Aulock, Sonja and Marquardt, H W J and Blaauboer, Bas J and Dekant, Wolfgang and Kehrer, James and Hengstler, Jan G and Collier, Abby C and Gori, Gio Batta and Pelkonen, Olavi and Lang, Florian and Nijkamp, Frans P and Stemmer, Kerstin and Li, Albert and Savolainen, Kai and Hayes, A Wallace and Gooderham, Nigel and Harvey, Alan (2013) Open letter to the European Commission : scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles. Archives of Toxicology, 87 (9). pp. 1739-1741.

Fathi, Behrooz and Harvey, Alan L and Rowan, Edward G (2013) The effect of temperature on the effects of the phospholipase A₂ neurotoxins β-bungarotoxin and taipoxin at the neuromuscular junction. Toxicon, 70. pp. 86-89. ISSN 1879-3150

Bansal, R. and Narang, G. and Calle, C. and Carron, R. and Pemberton, K. and Harvey, A.L. (2013) Synthesis of 4-(Carbonyloxyphenyl)-1,4-dihydropyridines as potential antihypertensive agents. Drug Development Research, 74 (1). pp. 50-61. ISSN 0272-4391

Dietrich, Daniel R and von Aulock, Sonja and Marquardt, Hans and Blaauboer, Bas and Dekant, Wolfgang and Kehrer, James and Hengstler, Jan and Collier, Abby and Batta Gori, Gio and Pelkonen, Olavi and Lang, Florian and Nijkamp, Frans P and Stemmer, Kerstin and Li, Albert and Savolainen, Kai and Wallace Hayes, A and Gooderham, Nigel and Harvey, Alan (2013) Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. ALTEX : Alternatives to Animal Experimentation, 30 (3). pp. 381-382. ISSN 1868-596X

Gebruers, Evelien and Cordero-Maldonado, María Lorena and Gray, Alexander I and Clements, Carol and Harvey, Alan L and Edrada-Ebel, Ruangelie and de Witte, Peter A M and Crawford, Alexander D and Esguerra, Camila V (2013) A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling. PLOS One, 8 (12). e83293. ISSN 1932-6203

Harvey, Alan L and Young, Louise C and Kornisiuk, Edgar and Snitcofsky, Marina and Colettis, Natalia and Blanco, Carlos and Jerusalinsky, Diana and Jamieson, Andrew G and Hartley, Richard C and Stone, Trevor W (2012) A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A(1) receptors and enhances consolidation of step-down avoidance. Behavioural Brain Research, 234 (2). pp. 184-191. ISSN 1872-7549

Ständker, L. and Forssmann, W.G. and Béress, L. and Harvey, A.L. and Fürst, S. and Mathes, I. and Escalona de Motta, G. (2012) Improved method for the isolation, characterization and examination of neuromuscular and toxic properties of selected polypeptide fractions from the crude venom of the Taiwan cobra Naja naja atra. Toxicon, 60 (4). pp. 623-631. ISSN 1879-3150

Bansal, R. and Jain, P. and Calle, C. and Carron, R. and Pemberton, K. and Harvey, A.L. (2012) Synthesis of a new series of 4-Aryl-1,4-dihydropyridines with calcium channel blocking and vasodilatory activity. Medicinal Chemistry Research, 21 (6). pp. 908-921. ISSN 1054-2523

Bansal, Ranju and Guleria, Sheetal and Thota, Sridhar and Bodhankar, Subhash L and Patwardhan, Moreshwar R and Zimmer, Christina and Hartmann, Rolf W and Harvey, Alan L (2012) Design, synthesis and evaluation of novel 16-imidazolyl substituted steroidal derivatives possessing potent diversified pharmacological properties. Steroids, 77 (6). pp. 621-629.

Harvey, A.L. and Stöcklin, R. (2012) From venoms to drugs : introduction. Toxicon, 59 (4). p. 433. ISSN 1879-3150

Harvey, Alan L and Young, Louise C and Viljoen, Alvaro M and Gericke, Nigel P (2011) Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids. Journal of Ethnopharmacology, 137 (3). 1124–1129. ISSN 1872-7573

Kornisiuk, Edgar and Snitcofsky, Marina and Blanco, Carlos and Harvey, Alan L and Stone, Trevor W and Jerusalinsky, Diana (2011) Memory impairment in rats by hippocampal administration of the serine protease subtilisin. Behavioural Brain Research, 219 (1). pp. 63-67. ISSN 1872-7549

Spencer, John and Rathnam, Rajendra P. and Harvey, Alan L. and Clements, Carol J. and Clark, Rachel L. and Barrett, Michael P. and Wong, Pui Ee and Male, Louise and Coles, Simon J. and Mackay, Simon P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19 (5). pp. 1802-1815.

Bansal, Ranju and Guleria, Sheetal and Young, Louise C and Harvey, Alan L (2011) Synthesis of quaternary ammonium salts of 16E-[4-(2-alkylaminoethoxy)-3-methoxybenzylidene]androstene derivatives as skeletal muscle relaxants. Steroids, 76 (3). pp. 254-260.

Crawford, A. D. and Challal, S. and Buenafe, O. E. and Harvey, A. L. and Esguerra, C. V. and De Witte, P. A. and Wolfender, J. (2011) Microgram-scale, in vivo natural product discovery using zebrafish bioassays, UHPLC-TOF-MS and microflow NMR : identification of anticonvulsants in the Philippine medicinal plant Solanum torvum. Planta Medica, 77 (12). pp. 1348-1349. PG70. ISSN 0032-0943

Rowan, E. G. and Harvey, A. L. (2011) Snake toxins from mamba venoms : unique tools for the physiologist. Acta Chimica Slovenica, 58 (4). pp. 689-692. ISSN 1318-0207

Fathi, Behrooz and Harvey, Alan L and Rowan, Edward G (2011) Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: a twitch tension study. Journal of Venom Research, 2. pp. 6-10.

Bansal, Ranju and Kumar, Gulshan and Gandhi, Deepika and Young, Louise C and Harvey, Alan L (2011) Synthesis of a new series of 1H-imidazol-1-yl substituted 8-phenylxanthines as adenosine receptor ligands. Chemistry and Biodiversity, 8 (7). pp. 1290-1300.

Harvey, A.L. (2010) Plant natural products in anti-diabetic drug discovery. Current Organic Chemistry, 14 (16). pp. 1670-1677. ISSN 1385-2728

Cree, Ian A and Glaysher, Sharon and Harvey, Alan L (2010) Efficacy of anti-cancer agents in cell lines versus human primary tumour tissue. Current Opinion in Pharmacology, 10 (4). pp. 375-9.

Harvey, Alan L and Cree, Ian A (2010) High-throughput screening of natural products for cancer therapy. Planta Medica, 76 (11). pp. 1080-1086.

Clark, Rachel L and Johnston, Blair F and Mackay, Simon P and Breslin, Catherine J and Robertson, Murray N and Harvey, Alan L (2010) The drug discovery portal : a resource to enhance drug discovery from academia. Drug Discovery Today, 15 (15-16). pp. 679-683.

Harvey, Alan and Clark, Rachel and Mackay, Simon and Johnston, Blair (2010) Current strategies for drug discovery through natural products. Expert Opinion on Drug Discovery, 5 (6). pp. 559-568.

Clark, Rachel and Johnston, Blair and Mackay, Simon and Breslin, Catherine and Robertson, Murray and Sutcliffe, Oliver Brook and Dufton, Mark and Harvey, Alan (2010) The drug discovery portal : a computational platform for identifying drug leads from academia. Current Pharmaceutical Design, 16 (15). pp. 1697-1702. ISSN 1381-6128

Bansal, Ranju and Kumar, Gulshan and Gandhi, Deepika and Yadav, Rakesh and Young, Louise C and Harvey, Alan L (2010) Synthesis of 8-(cyclopentyloxy)phenyl substituted xanthine derivatives as adenosine A2A ligands. Arzneimittel Forschung, 60 (3). pp. 131-136. ISSN 0004-4172

Clark, R.L. and Johnston, B.F. and Mackay, S.P. and Breslin, C.J. and Robertson, Murray and Sutcliffe, O.B. and Dufton, M.J. and Harvey, A.L. (2010) The drug discovery portal : a computational platform for identifying drug leads from academia. Current Pharmaceutical Design, 16 (15). pp. 1697-1702. ISSN 1381-6128

Castañeda, Olga and Harvey, Alan L (2009) Discovery and characterization of cnidarian peptide toxins that affect neuronal potassium ion channels. Toxicon, 54 (8). pp. 1119-1124. ISSN 1879-3150

Makiyi, E.F. and Frade, R.F.M. and Lebl, T. and Jaffray, E.G. and Cobb, S. and Harvey, Alan L. and Slawin, A.M.Z. and Hay, R.T. (2009) The iso-secoi-tanapartholides: isolation, synthesis and biological evaluation. Agewandte Chemie-International Edition, 2009 (33). pp. 5711-5715. ISSN 1521-3773

Forbey, J.S. and Harvey, A.L. and Huffman, M.A. and Provenza, F.D. and Sullivan, R. and Tasdemir, D. (2009) Exploitation of secondary metabolites by animals : a response to homeostatic challenges. Integrative and Comparative Biology, 49 (3). pp. 314-328. ISSN 1540-7063

Bansal, R. and Kumar, G. and Gandhi, D. and Yadav, R. and Young, L.C. and Harvey, A.L. (2009) Synthesis of 8-(cyclopentyloxy)phenyl substituted xanthine derivatives as adenosine A2A ligands. ChemInform, 41 (33). ISSN 1522-2667

Coxon, Geoffrey D. and Furman, Brian L. and Harvey, Alan L. and McTavish, John and Mooney, Mark H. and Arastoo, Mahmoud and Kennedy, A.R. and Tettey, J.N.A. and Waigh, R.D. (2009) Benzylguanidines and other galegine analogues inducing weight loss in mice. Journal of Medicinal Chemistry, 52 (11). pp. 3457-3463. ISSN 0022-2623

Gibson, Colin L. and Huggan, J.K. and Kennedy, Alan and Kiefer, L. and Lee, Jeong Hwan and Suckling, C.J. and Clements, Caorl J. and Harvey, Alan L. and Hunter, William N. and Tulloch, Lindsay B. (2009) Diversity oriented syntheses of fused pyrimidines designed as potential antifolates. Organic and Biomolecular Chemistry, 7 (9). pp. 1829-1842. ISSN 1477-0520

Bansal, R. and Kumar, G. and Gandhi, D. and Young, Louise C. and Harvey, A.L. (2009) Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors. European Journal of Medicinal Chemistry, 44 (5). pp. 2122-2127. ISSN 0223-5234

Harvey, A.L. (2009) Biological screening assays for plant secondary metabolites. Integrative and Comparative Biology, 49 (1). E71-E71. ISSN 1540-7063

Harvey, Alan L (2008) Natural products in drug discovery. Drug Discovery Today, 13 (19-20). pp. 894-901. ISSN 1359-6446

Mooney, M.H. and Fogarty, S. and Stevenson, C. and Gallagher, A.M. and Palit, P. and Hawley, S.A. and Hardie, D.G. and Coxon, Geoffrey and Waigh, Roger and Tate, R. and Harvey, Alan and Furman, Brian (2008) Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. British Journal of Pharmacology, 153 (8). pp. 1669-1677. ISSN 1476-5381

MacGregor, Duncan G and Mallon, Andrew P and Harvey, Alan L and Young, Louise and Nimmo, Hugh G and Stone, Trevor W (2007) Group S8A serine proteases, including a novel enzyme cadeprin, induce long-lasting, metabotropic glutamate receptor-dependent synaptic depression in rat hippocampal slices. European Journal of Neuroscience, 26 (7). pp. 1870-80. ISSN 0953-816X

Harvey, Alan L (2007) Natural products as a screening resource. Current Opinion in Chemical Biology, 11 (5). pp. 480-484. ISSN 1367-5931

Harvey, A.L. and Rowan, E.G. (2007) Musculoskeletal pharmacology from developmental regulation to drugs in the clinic: expanding horizons in musculoskeletal pharmacology. Current Opinion in Pharmacology, 7 (3). pp. 296-297. ISSN 1471-4892

Jalali, A. and Vatanpour, H. and Hosseininasab, Z. and Rowan, E.G. and Harvey, Alan L. (2007) The effect of the venom of the yellow Iranian scorpion Odontobuthus doriae on skeletal muscle preparations in vitro. Toxicon, 50 (8). pp. 1019-1026. ISSN 1879-3150

Jain, P and Narang, G and Jindal, D P and Bansal, R and Calle, C and Carron, R and Pemberton, K and Harvey, A L (2006) Synthesis of a new series of 4-aryl-1,4-dihydropyridines with calcium channel blocking and vasodilatory activity. Pharmazie, 61 (5). pp. 400-405. ISSN 0031-7144

Harvey, A.L. and Robertson, Boyd (2004) Dendrotoxins: structure-activity relationships and effects on potassium ion channels. Current Medicinal Chemistry, 11 (23). pp. 3065-3072. ISSN 0929-8673

Asuzu, I U and Harvey, A L (2003) The antisnake venom activities of Parkia biglobosa (Mimosaceae) stem bark extract. Toxicon, 42 (7). pp. 763-768. ISSN 1879-3150

Bradley, Karen N. and Rowan, E.G. and Harvey, Alan L. (2003) Effects of muscarinic toxins MT2 and MT7, from green mamba venom, on m1, m3 and m5 muscarinic receptors expressed in Chinese hamster ovary cells. Toxicon, 41 (2). pp. 207-215. ISSN 1879-3150

Harvey, Alan L and Kornisiuk, Edgar and Bradley, Karen N and Cerveñansky, Carlos and Durán, Rosario and Adrover, Martin and Sánchez, Gonzalo and Jerusalinsky, Diana (2002) Effects of muscarinic toxins MT1 and MT2 from green mamba on different muscarinic cholinoceptors. Neurochemical Research, 27 (11). pp. 1543-1554. ISSN 0364-3190

Harvey, Alan L (2002) Toxins 'R' Us : more pharmacological tools from nature's superstore. Trends in Pharmacological Sciences, 23 (5). pp. 201-203. ISSN 0165-6147

Fatehi, M. and Rowan, E.G. and Harvey, A.L. (2002) An electrophysiological study on the effects of Pa-1G (a phospholipase A(2)) from the venom of king brown snake, Pseudechis australis, on neuromuscular function. Toxicon, 40 (1). pp. 69-75. ISSN 1879-3150

Fathi, B. and Rowan, E.G. and Harvey, A.L. (2001) The facilitatory actions of snake venom phospholipase a(2) neurotoxins at the neuromuscular junction are not mediated through voltage-gated k+ channels. Toxicon, 39 (12). pp. 1871-1882. ISSN 1879-3150

Cochran, S M and Harvey, A L and Pratt, J A (2001) Regionally selective alterations in local cerebral glucose utilization evoked by charybdotoxin, a blocker of central voltage-activated K+-channels. European Journal of Neuroscience, 14 (9). pp. 1455-1463. ISSN 0953-816X

Bradley, Karen and Rowan, Edward and Harvey, Alan L. (2001) Effects of brucine, a plant alkaloid, on M(1) muscarinic receptors and alpha(1)-adrenoceptors in the rabbit vas deferens preparation. Toxicon, 39 (4). pp. 581-587. ISSN 1879-3150

Harvey, A L (2001) Twenty years of dendrotoxins. Toxicon, 39 (1). pp. 15-26. ISSN 1879-3150

Fatani, A.J. and Harvey, A.L. and Furman, B.L. and Rowan, E.G. (2000) The effects of lignocaine on actions of the venom from the yellow scorpion "leiurus quinquestriatus" in vivo and in vitro. Toxicon, 38 (12). pp. 1787-1801. ISSN 1879-3150

Proctor, G R and Harvey, A L (2000) Synthesis of tacrine analogues and their structure-activity relationships. Current Medicinal Chemistry, 7 (3). pp. 295-302. ISSN 0929-8673

Alessandri-Haber, N. and Lecoq, A. and Gasparini, S. and Grangier-Macmath, G. and Jacquet, G. and Harvey, Alan L. and de Medeiros, C. and Rowan, Edward G. and Gola, M. and Ménez, A. and Crest, M. (1999) Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. : Clues to design analogs with enhanced selectivity. Journal of Biological Chemistry, 274 (50). pp. 35653-35661. ISSN 1083-351X

Harvey, A L (1999) Medicines from nature : are natural products still relevant to drug discovery? Trends in Pharmacological Sciences, 20 (5). pp. 196-198. ISSN 0165-6147

Harvey, A.L. and Bradley, K.N. and Cochran, S.A. and Rowan, E.G. and Pratt, J.A. and Quillfeldt, J.A. and Jerusalinsky, D.A. (1998) What can toxins tell us for drug discovery? Toxicon, 36 (11). pp. 1635-1640. ISSN 1879-3150

Harvey, A L and Waterman, P G (1998) The continuing contribution of biodiversity to drug discovery. Current opinion in drug discovery & development, 1 (1). pp. 71-76. ISSN 1367-6733

Nishio, H. and Inui, T. and Nishiuchi, Y. and De Medeiros, C.L.C. and Rowan, E.G. and Harvey, A.L. and Katoh, E. and Yamazaki, T. (1998) Chemical synthesis of dendrotoxin-i : revision of the reported structure. Journal of Peptide Research, 51 (5). pp. 355-364. ISSN 1397-002X

Alzahaby, M. and Harvey, A.L. and Young, L.C. and Faure, G. and Rowan, E.G. (1998) Purification of a 5-ht uptake inhibitor from the venom of cerastes vipera. Toxicon, 36 (4). pp. 601-607. ISSN 1879-3150

Fatehi, M. and Harvey, A.L. and Rowan, E.G. (1998) Characterisation of the effects of depolarising toxins on nerve terminal action potentials: apparent block of presynaptic potassium currents. Toxicon, 36 (1). pp. 115-129. ISSN 1879-3150

Poorheidari, G. and Rowan, E.G. and Harvey, A.L. (1998) Isolation of a postsynaptic blocker from the venom of the green mamba, dendroaspis angusticeps. Naunyn-Schmiedeberg's Archives of Pharmacology, 358 (1). R445-R445.

McKenna, M T and Proctor, G R and Young, L C and Harvey, A L (1997) Novel tacrine analogues for potential use against Alzheimer's disease : potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Journal of Medicinal Chemistry, 40 (22). pp. 3516-3523. ISSN 0022-2623

Gendeh, G S and Young, L C and de Medeiros, C L and Jeyaseelan, K and Harvey, A L and Chung, M C (1997) A new potassium channel toxin from the sea anemone Heteractis magnifica : isolation, cDNA cloning, and functional expression. BMC Biochemistry, 36 (38). pp. 11461-11471. ISSN 1471-2091

Harvey, A.L. and Rowan, E.G. and Vatanpour, H. and Engstrom, A. and Westerlund, B. and Karlsson, E. (1997) Changes to biological activity following acetylation of dendrotoxin I from Dendroaspis polylepis (black mamba). Toxicon, 35 (8). pp. 1263-1273. ISSN 1879-3150

Bradley, K.N. and Harvey, A.L. and Rowan, E.G. (1997) Use of muscarinic toxins, mtx1, mtx2 and mtx3, in the study of synaptic transmission in the peripheral nervous system. Life Sciences, 60 (13-14). p. 91.

Cotton, J and Crest, M and Bouet, F and Alessandri, N and Gola, M and Forest, E and Karlsson, E and Castañeda, O and Harvey, A L and Vita, C and Ménez, A (1997) A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity. European Journal of Biochemistry, 244 (1). pp. 192-202. ISSN 0014-2956

Fatehi, M. and Rowan, E.G. and Harvey, A.L. and Moya, E. and Blagbrough, I.S. (1997) Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals. Neuropharmacology, 36 (2). pp. 185-94. ISSN 0028-3908

Harvey, A L (1997) Recent studies on dendrotoxins and potassium ion channels. General pharmacology, 28 (1). pp. 7-12. ISSN 0306-3623

Rowan, E.G. and Harvey, A.L. (1996) Toxins affecting k+ channels. Brazilian Journal of Medical and Biological Research, 29 (12). pp. 1765-1780. ISSN 0100-879X

Henning, R.H. and Rowan, E.G. and Braga, M.F.M. and Nelemans, A. and Harvey, A.L. (1996) The prejunctional inhibitory effect of suramin on neuromuscular transmission in vitro. European Journal of Pharmacology, 301 (1-3). pp. 91-97. ISSN 0014-2999

Wüster, W and Harvey, A L (1996) Reviews of venomous snake systematics in Toxicon. Toxicon, 34 (4). pp. 397-398. ISSN 1879-3150

Fatehi, M. and Rowan, E.G. and Harvey, A.L. (1995) Temperature-dependent effects of adenosine on presynaptic calcium currents and acetylcholine-release from mouse motor-nerve terminals. British Journal of Pharmacology, 116 (Supple). P365-P365. ISSN 1476-5381

Fatehi, M. and Rowan, E.G. and Harvey, A.L. and Moya, E. and Blagbrough, I.S. (1995) The effects of polyamine ftx-3.3 and polyamine amide sftx-3.3 on acetyccholine release. British Journal of Pharmacology, 116 (Supple). P367-P367. ISSN 1476-5381

Fatehi, M. and Rowan, E.G. and Harvey, A.L. (1995) The effects of two phospholipase A(2) inhibitors on the neuromuscular blocking activities of homologous phospholipases A(2) from the venom of Pseudechis australis, the Australian king brown snake. Toxicon, 33 (12). pp. 1633-1643. ISSN 1879-3150

Braga, M.F.M. and Rowan, E.G. and Harvey, A.L. (1995) Modification of ionic currents underlying action-potentials in mouse nerve-terminals by the thiol-oxidizing agent diamide. Neuropharmacology, 34 (11). pp. 1529-1533. ISSN 0028-3908

Alzahaby, M. and Rowan, E.G. and Young, L.C. and Al-Zahaby, A.S. and Abu-Sinna, G. and Harvey, A.L. (1995) Some pharmacological studies on the effects of Cerastes vipera (Sahara sand viper) snake-venom. Toxicon, 33 (10). pp. 1299-1311. ISSN 1879-3150

Castañeda, O and Sotolongo, V and Amor, A M and Stöcklin, R and Anderson, A J and Harvey, A L and Engström, A and Wernstedt, C and Karlsson, E (1995) Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon, 33 (5). pp. 603-613. ISSN 1879-3150

Warrell, D A and Harvey, A L (1995) Clinical reports in Toxicon. Toxicon, 33 (5). pp. 583-584. ISSN 1879-3150

Vatanpour, H and Harvey, A L (1995) Modulation of acetylcholine release at mouse neuromuscular junctions by interaction of three homologous scorpion toxins with K+ channels. British Journal of Pharmacology, 114 (7). pp. 1502-1506. ISSN 1476-5381

Harvey, A.L. and Vatanpour, H. and Rowan, E.G. and Pinkasfeld, S. and Vita, C. and Menez, A. and Martineauclaire, M.F. (1995) Structure-activity studies on scorpion toxins that block potassium channels. Toxicon, 33 (4). pp. 425-436. ISSN 1879-3150

Kornisiuk, E and Jerusalinsky, D and Cerveñansky, C and Harvey, A L (1995) Binding of muscarinic toxins MTx1 and MTx2 from the venom of the green mamba Dendroaspis angusticeps to cloned human muscarinic cholinoceptors. Toxicon, 33 (1). pp. 11-18. ISSN 1879-3150

Bowman, W C and Harvey, A L (1995) The discovery of drugs. Proceedings- Royal College of Physicians of Edinburgh, 25 (1). pp. 5-24. ISSN 0953-0932

Harvey, A L (1995) The pharmacology of galanthamine and its analogues. Pharmacology and Therapeutics, 68 (1). pp. 113-128. ISSN 0163-7258

Danse, J.M. and Rowan, E.G. and Gasparini, S. and Ducancel, F. and Vatanpour, H. and Young, L.C. and Poorheidari, G. and Lajeunesse, E. and Harvey, A.L. (1994) On the site by which alpha-dendrotoxin binds to voltage-dependent potassium channels: Site-directed mutagenesis reveals that the lysine triplet 28-30 is not essential for binding. FEBS Letters, 356 (2-3). pp. 153-158. ISSN 0014-5793

Fatehi, M. and Rowan, E.G. and Harvey, A.L. and Harris, J.B. (1994) The effects of five phospholipase A-2 from the venom of king brown snake, Pseudechis australis, on nerve and muscle. Toxicon, 32 (12). pp. 1559-1572. ISSN 1879-3150

Marshall, D L and Vatanpour, H and Harvey, A L and Boyot, P and Pinkasfeld, S and Doljansky, Y and Bouet, F and Ménez, A (1994) Neuromuscular effects of some potassium channel blocking toxins from the venom of the scorpion Leiurus quinquestriatus hebreus. Toxicon, 32 (11). pp. 1433-1443. ISSN 1879-3150

Jerusalinsky, D and Harvey, A L (1994) Toxins from mamba venoms : small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors. Trends in Pharmacological Sciences, 15 (11). pp. 424-430. ISSN 0165-6147

Fatehi, M. and Rowan, E.G. and Harvey, A.L. (1994) Characterization of the effects of depolarizing phospholipases A-2, myotoxin a and ouabain on the perineural waveforms recorded from mouse motor nerve endings. British Journal of Pharmacology, 112 (Supple). U76-U76. ISSN 1476-5381

Barfaraz, A and Harvey, A L (1994) The use of the chick biventer cervicis preparation to assess the protective activity of six international reference antivenoms on the neuromuscular effects of snake venoms in vitro. Toxicon, 32 (3). pp. 267-272. ISSN 1879-3150

Braga, M.F.M. and Rowan, E.G. and Harvey, A.L. and Bowman, W.C. (1994) Interactions between suxamethonium and non-depolarizing neuromuscular blocking-drugs. British Journal of Anaesthesia, 72 (2). pp. 198-204. ISSN 0007-0912

Habtemariam, S and Harvey, A L and Waterman, P G (1993) The muscle relaxant properties of Portulaca oleracea are associated with high concentrations of potassium ions. Journal of Ethnopharmacology, 40 (3). pp. 195-200. ISSN 1872-7573

Vatanpour, H. and Rowan, E.G. and Harvey, A.L. (1993) Effects of scorpion (Buthus-tamulus) venom on neuromuscular transmission in vitro. Toxicon, 31 (11). pp. 1373-1384. ISSN 1879-3150

Harvey, A L and Barfaraz, A and Thomson, E and Faiz, A and Preston, S and Harris, J B (1993) Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks. Toxicon, 32 (3). pp. 257-265. ISSN 1879-3150

Vita, C and Bontems, F and Bouet, F and Tauc, M and Poujeol, P and Vatanpour, H and Harvey, A L and Ménez, A and Toma, F (1993) Synthesis of charybdotoxin and of two N-terminal truncated analogues. Structural and functional characterisation. European Journal of Biochemistry, 217 (1). pp. 157-169. ISSN 0014-2956

Hollecker, M and Marshall, D L and Harvey, A L (1993) Structural features important for the biological activity of the potassium channel blocking dendrotoxins. British Journal of Pharmacology, 110 (2). pp. 790-794. ISSN 1476-5381

Faure, G and Harvey, A L and Thomson, E and Saliou, B and Radvanyi, F and Bon, C (1993) Comparison of crotoxin isoforms reveals that stability of the complex plays a major role in its pharmacological action. European Journal of Biochemistry, 214 (2). pp. 491-496. ISSN 0014-2956

Aneiros, A and García, I and Martínez, J R and Harvey, A L and Anderson, A J and Marshall, D L and Engström, A and Hellman, U and Karlsson, E (1993) A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity. BBA - Biochimica et Biophysica Acta, 1157 (1). pp. 86-92. ISSN 0006-3002

Xie, K and Harvey, A L (1993) Evaluation of nerve cell toxicity in vitro by electrophysiological and biochemical methods. Toxicology in Vitro, 7 (3). pp. 275-279. ISSN 0887-2333

Braga, M.F.M. and Rowan, E.G. and Harvey, Alan L. and Bowman, W.C. (1993) Prejunctional action of neostigmine on mouse neuromuscular preparations. British Journal of Anaesthesia, 70 (4). pp. 405-410. ISSN 0007-0912

Harvey, A L (1993) Neuropharmacology of potassium ion channels. Medicinal Research Reviews, 13 (1). pp. 81-104. ISSN 0198-6325

Harvey, A L and Marshall, D L and Possani, L D (1992) Dendrotoxin-like effects of noxiustoxin. Toxicon, 30 (11). pp. 1497-1500. ISSN 1879-3150

Rowan, E.G. and Vatanpour, H. and Furman, B.L. and Harvey, A.L. and Tanira, M.O.M. and Gopalakrishnakone, P. (1992) The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro. Toxicon, 30 (10). pp. 1157-1164. ISSN 1879-3150

Geh, S.L and Rowan, E.G. and Harvey, Alan L. (1992) Neuromuscular effects of four phospholipases A2 from the venom of Pseudechis australis, the Australian king brown snake. Toxicon, 30 (9). pp. 1051-1057. ISSN 1879-3150

Braga, M.F.M. and Anderson, A.J. and Harvey, A.L. and Rowan, E.G. (1992) Apparent block of K+ currents in mouse motor nerve terminals by tetrodotoxin, mu-conotoxin and reduced external sodium. British Journal of Pharmacology, 106 (1). pp. 91-94. ISSN 1476-5381

Marshall, D L and Harvey, A L (1992) Protease inhibitor homologues of dendrotoxin do not bind to dendrotoxin acceptors on synaptosomal membranes or facilitate neuromuscular transmission. Biological chemistry Hoppe-Seyler, 373 (8). pp. 707-714. ISSN 0177-3593

Braga, M.F.M. and Harvey, A.L. and Rowan, E.G. (1991) Effects of tacrine, velnacrine (HP029), suronacrine (HP128),and 3,4-diaminopyridine on skeletal neuromusculartransmission in vitro. British Journal of Pharmacology, 102 (4). pp. 909-915. ISSN 1476-5381

Ducancel, F. and Rowan, E.G. and Cassar, E. and Harvey, A.L. and Menez, A. and Boulain, J.C. (1991) Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence. Toxicon, 29 (4-5). pp. 516-520. ISSN 1879-3150

Rowan, E.G. and Harvey, A.L. and Menez, A. (1991) Neuromuscular effects of nigexine, a basic phospholipase-a2 from naja-nigricollis venom. Toxicon, 29 (3). pp. 371-374. ISSN 1879-3150

Ménez, A and Gatineau, E and Roumestand, C and Harvey, A L and Mouawad, L and Gilquin, B and Toma, F (1990) Do cardiotoxins possess a functional site? Structural and chemical modification studies reveal the functional site of the cardiotoxin from Naja nigricollis. Biochimie, 72 (8). pp. 575-588. ISSN 0300-9084

Gatineau, E and Takechi, M and Bouet, F and Mansuelle, P and Rochat, H and Harvey, A L and Montenay-Garestier, T and Ménez, A (1990) Delineation of the functional site of a snake venom cardiotoxin : preparation, structure, and function of monoacetylated derivatives. BMC Biochemistry, 29 (27). pp. 6480-6489. ISSN 1471-2091

Rowan, E.G. and Pemberton, K.E. and Harvey, Alan L. (1990) On the blockade of acetylcholine release at mouse motor nerve terminals by beta-bungarotoxin and crotoxin. British Journal of Pharmacology, 100 (2). pp. 301-304. ISSN 1476-5381

Harvey, A.L. and Braga, M.F.M. and Rowan, E.G. (1990) Temperature-dependent effects of tacrine on cholinergic transmission. Neurobiology of Aging, 11 (3). p. 344. ISSN 0197-4580

Rowan, E.G. and Ducancel, F. and Doljansky, Y. and Harvey, A.L. and Boulain, J.C. and Menez, A. (1990) Nucleotide-sequence encoding a synergistic-like protein from the venom glands of Dendroaspis angusticeps. Nucleic Acids Research, 18 (6). p. 1639. ISSN 1362-4962

Chwetzoff, S. and Mollier, P. and Bouet, F. and Rowan, E.G. and Harvey, A.L. and Menez, A. (1990) On the purification of notexin: isolation of a single amino acid variant from the venom of Notechis scutatus scutatus. FEBS Letters, 261 (2). pp. 226-230. ISSN 0014-5793

Takasaki, C. and Sugama, A. and Yanagita, A. and Tamiya, N. and Rowan, E.G. and Harvey, A.L. (1990) Effects of chemical modifications of Pa-11, a phospholipase A2 from the venom of Australian king brown snake (Pseudechis australis), on its biological activities. Toxicon, 28 (1). pp. 107-117. ISSN 1879-3150

Harvey, Alan L. and Rowan, E.G. (1990) Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents. Advances in Neurology, 51. pp. 227-233. ISSN 0091-3952

Harvey, A.L. and Anderson, A.J. and Marshall, D.L. and Pemberton, K.E. and Rowan, E.G. (1990) Facilitatory neurotoxins and transmitter release. Journal of Toxicology: Toxin Reviews, 9 (2). pp. 225-242. ISSN 1556-9551

Harvey, Alan L. and Rowan, E.G. and Anderson, A.J. (1989) Potassium channel blockers and neuronal function. Pflugers Archiv - European Journal of Physiology, 414 (Supple). S106-S110. ISSN 0031-6768

Marshall, D L and Harvey, A L (1989) Block of potassium channels and facilitation of acetylcholine release at the neuromuscular junction by the venom of the scorpion, Pandinus imperator. Toxicon, 27 (4). pp. 493-498. ISSN 1879-3150

Rowan, E.G. and Harvey, Alan L. and Takasaki, C. and Tamiya, N. (1989) Neuromuscular effects of a toxic phospholipase A2 and its nontoxic homologue from the venom of the sea snake, Laticauda colubrina. Toxicon, 27 (5). pp. 587-91. ISSN 1879-3150

Rowan, E.G. and Harvey, A.L. and Takasaki, C. and Tamiya, N. (1989) Neuromuscular effects of three phospholipases A2 from the venom of the Australian king brown snake Pseudechis australis. Toxicon, 27 (5). pp. 551-560. ISSN 1879-3150

Anderson, A.J. and Harvey, Alan L. and Rowan, E.G. and Strong, P.N. (1988) Effects of charybdotoxin, a blocker of Ca2+-activated K+ channels, on motor nerve terminals. British Journal of Pharmacology, 95 (4). pp. 1329-1335. ISSN 1476-5381

Anderson, A J and Harvey, A L (1988) Effects of the facilitatory compounds catechol, guanidine, noradrenaline and phencyclidine on presynaptic currents of mouse motor nerve terminals. Naunyn-Schmiedeberg's Archives of Pharmacology, 338 (2). pp. 133-137. ISSN 0028-1298

Rowan, E.G. and Harvey, Alan L. (1988) Potassium channel blocking actions of beta-bungarotoxin and related toxins on mouse and frog motor nerve terminals. British Journal of Pharmacology, 94 (3). pp. 839-847. ISSN 1476-5381

Harvey, A L (1988) Possible developments in neurotoxicity testing in vitro. Xenobiotica, 18 (6). pp. 625-632. ISSN 0049-8254

Anderson, A J and Harvey, A L (1988) Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity. British Journal of Pharmacology, 93 (1). pp. 215-221. ISSN 1476-5381

Anderson, A J and Harvey, A L (1987) Omega-conotoxin does not block the verapamil-sensitive calcium channels at mouse motor nerve terminals. Neuroscience Letters, 82 (2). pp. 177-180. ISSN 0304-3940

Hodges, S J and Agbaji, A S and Harvey, A L and Hider, R C (1987) Cobra cardiotoxins. Purification, effects on skeletal muscle and structure/activity relationships. European Journal of Biochemistry, 165 (2). pp. 373-383. ISSN 0014-2956

Harvey, A L and Hayashi, K (1987) Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra). Toxicon, 25 (6). pp. 681-684. ISSN 1879-3150

Harvey, A L and Anderson, A J (1985) Dendrotoxins : snake toxins that block potassium channels and facilitate neurotransmitter release. Pharmacology and Therapeutics, 31 (1-2). pp. 33-55. ISSN 0163-7258

Rowan, E.G. and Harvey, A.L. and Tamiya, N. (1985) Effects of 2 phospholipases a2 from the australian king brown snake (pseudechis-australis) on isolated nerve-muscle preparations. Toxicon, 23 (4). p. 606. ISSN 1879-3150

Rowan, E.G. and Harvey, A.L. and Tamiya, N. (1985) Neuromuscular effects of a toxic phospholipase-a2 isolated from venom of the solomon-island sea-snake laticauda-colubrina. Toxicon, 23 (4). p. 606. ISSN 1879-3150

Harvey, A L and Anderson, A J and Karlsson, E (1984) Facilitation of transmitter release by neurotoxins from snake venoms. Journal de physiologie, 79 (4). pp. 222-227. ISSN 0021-7948

Harvey, A L and Hider, R C and Hodges, S J and Joubert, F J (1984) Structure-activity studies of homologues of short chain neurotoxins from Elapid snake venoms. British Journal of Pharmacology, 82 (3). pp. 709-716. ISSN 1476-5381

Harvey, A L and Hider, R C and Khader, F (1983) Effect of phospholipase A on actions of cobra venom cardiotoxins on erythrocytes and skeletal muscle. BBA - Biochimica et Biophysica Acta, 728 (2). pp. 215-221. ISSN 0006-3002

Harvey, A L and Marshall, R J and Karlsson, E (1982) Effects of purified cardiotoxins from the Thailand cobra (Naja naja siamensis) on isolated skeletal and cardiac muscle preparations. Toxicon, 20 (2). pp. 379-396. ISSN 1879-3150

Singh, Y N and Marshall, I G and Harvey, A L (1982) Pre- and postjunctional blocking effects of aminoglycoside, polymyxin, tetracycline and lincosamide antibiotics. British Journal of Anaesthesia, 54 (12). pp. 1295-1306. ISSN 0007-0912

Harvey, A L and Karlsson, E (1982) Protease inhibitor homologues from mamba venoms : facilitation of acetylcholine release and interactions with prejunctional blocking toxins. British Journal of Pharmacology, 77 (1). pp. 153-161. ISSN 1476-5381

Harvey, A L and van Helden, D (1981) Acetylcholine receptors in singly and multiply innervated skeletal muscle fibres of the chicken during development. Journal of Physiology, 317. pp. 397-411. ISSN 0022-3751

Book Section

Harvey, Alan; Audenaert, Dominique and Overvoorde, Paul, eds. (2014) Natural product-based libraries. In: Plant Chemical Biology. Wiley and Sons, pp. 64-72. ISBN 978-0-470-94669-5

Harvey, A.L.; Kastin, Abba, ed. (2013) Snake peptides. In: Handbook of Biologically Active Peptides. Academic Press, pp. 451-460. ISBN 9780123850959

Harvey, Alan; Cechinel-Filho, Valdir, ed. (2012) Screening methods for drug discovery from plants. In: Plant Bioactives and Drug Discovery. Wiley and Sons, pp. 489-498. ISBN 978-0-470-58226-8

Harvey, Alan L.; Mackessy, S.P., ed. (2009) Fasciculins: Toxins from Mamba venoms that inhibit acetylcholinesterase. In: Handbook of Venoms and Toxins of Reptiles. CRC Press, pp. 317-324. ISBN 9780849391651

Harvey, A.L.; Carpinella, María C. and Rai, M., eds. (2009) Bridging the gap: using natural products in drug discovery research in academia and industry. In: Novel Therapeutic Agents from Plants. Science Publishers, pp. 164-174. ISBN 9781578085460

Harvey, Alan L.; de Lima, M.E. and Pimenta, A.M.C. and Martin-Eauclaire, M.F. and Zingali, R. and Rochat, H., eds. (2009) Dendrotoxins from mamba venoms: tools to study voltage-activated potassium ion channels. In: Animal toxins: state of the art - perspectives in health and biotechnology. Editora UFMG, pp. 473-480. ISBN 978-85-7041-735-0

Harvey, Alan L.; de Lima, M.E. and Pimenta, A.M.C. and Martin-Eauclaire, M.F. and Zingali, R. and Rochat, H., eds. (2009) Overview: animal toxins, state of the art. In: Animal toxins: state of the art - perspectives in health and biotechnology. Editora UFMG, pp. 19-22. ISBN 978-85-7041-735-0