Toxins 'R' Us : more pharmacological tools from nature's superstore

Harvey, Alan L (2002) Toxins 'R' Us : more pharmacological tools from nature's superstore. Trends in Pharmacological Sciences, 23 (5). pp. 201-203. ISSN 0165-6147 (https://doi.org/10.1016/S0165-6147(02)02012-6)

Abstract

Conus venoms from marine cone snails continue to provide novel bioactive components. Two new classes of conopeptide specifically block alpha(1)-adrenoceptors (rho-conopeptide) and noradrenaline transporters (chi-conopeptides). Both classes are small peptides with two disulfide bonds. Rho-conopeptide is structurally similar to alpha-conotoxins, which block nicotinic acetylcholine receptors, whereas the chi-conopeptides are unrelated to other conotoxins. Both types of conopeptides are non-competitive blockers. Because these peptides demonstrate greater selectivity than current drugs in clinical use, they could lead to the development of improved therapeutics.

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• Item metadata

  Item type:	Article
  ID code:	31608
  Dates:	Date Event May 2002 Published 8 May 2002 Published Online
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
  Depositing user:	Pure Administrator
  Date deposited:	13 Jul 2011 08:56
  Last modified:	08 Apr 2024 19:12
  URI:	https://strathprints.strath.ac.uk/id/eprint/31608