Exploitation of secondary metabolites by animals : a response to homeostatic challenges
Forbey, J.S. and Harvey, A.L. and Huffman, M.A. and Provenza, F.D. and Sullivan, R. and Tasdemir, D. (2009) Exploitation of secondary metabolites by animals : a response to homeostatic challenges. Integrative and Comparative Biology, 49 (3). pp. 314-328. ISSN 1540-7063 (https://doi.org/10.1093/icb/icp046)
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We propose that the exploitation of the bioactive properties of secondary metabolites (SMs) by animals can provide a "treatment" against various challenges that perturb homeostasis in animals. The unified theoretical framework for the exploitation of SMs by animals is based on a synthesis of research from a wide range of fields and although it is focused on providing generalized predictions for herbivores that exploit SMs of plants, predictions can be applied to understand the exploitation of SMs by many animals. In this review, we argue that the probability of SM exploitation is determined by the relative difference between the cost of a homeostatic challenge and the toxicity of the SM and we provide various predictions that can be made when considering behavior under a homeostatic perspective. The notion that animals experience and respond to costly challenges by exploiting therapeutic SMs provides a relatively novel perspective to explain foraging behavior in herbivores, specifically, and behavior of animals in general. We provide evidence that animals can exploit the biological activity of SMs to mitigate the costs of infection by parasites, enhance reproduction, moderate thermoregulation, avoid predation, and increase alertness. We stress that a better understanding of animal behavior requires that ecologists look beyond their biases that SMs elicit punishment and consider a broader view of avoidance or selection of SMs relative to the homeostatic state. Finally, we explain how understanding exploitation of SMs by animals could be applied to advance practices of animal management and lead to discovery of new drugs.
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Item type: Article ID code: 18964 Dates: DateEventSeptember 2009Published22 June 2009Published OnlineSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Strathprints Administrator Date deposited: 22 Jun 2010 10:36 Last modified: 02 Aug 2024 11:06 URI: https://strathprints.strath.ac.uk/id/eprint/18964