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Protease inhibitor homologues of dendrotoxin do not bind to dendrotoxin acceptors on synaptosomal membranes or facilitate neuromuscular transmission

Marshall, D L and Harvey, A L (1992) Protease inhibitor homologues of dendrotoxin do not bind to dendrotoxin acceptors on synaptosomal membranes or facilitate neuromuscular transmission. Biological chemistry Hoppe-Seyler, 373 (8). pp. 707-714. ISSN 0177-3593

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Abstract

The dendrotoxins are a homologous group of potassium channel-blocking polypeptides found in mamba snake venom. They are similar in sequence and structure to Kunitz-type serine protease inhibitors. Modified and native protease inhibitors were assayed for dendrotoxin-like activity using radioligand-binding and twitch tension-recording methods. Despite the large number and high concentration of compounds tested, no protease inhibitor displayed dendrotoxin-like activity. The results indicate that the protease-inhibiting and potassium channel-blocking activities of these two groups of polypeptides are not linked.

Item type: Article
ID code: 31675
Keywords: amino acid sequence, animals, chickens, elapid venoms, iodine radioisotopes, kinetics, membranes, molecular sequence data, muscle contraction, neuromuscular junction, potassium channels, protease inhibitors, radioligand assay, rats, cholinergic receptors, structure-activity relationship, synaptic transmission, synaptosomes, Biochemistry
Subjects: UNSPECIFIED
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited: 13 Jul 2011 08:56
Last modified: 03 Jan 2019 12:58
URI: https://strathprints.strath.ac.uk/id/eprint/31675
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