Protease inhibitor homologues of dendrotoxin do not bind to dendrotoxin acceptors on synaptosomal membranes or facilitate neuromuscular transmission

Marshall, D L and Harvey, A L (1992) Protease inhibitor homologues of dendrotoxin do not bind to dendrotoxin acceptors on synaptosomal membranes or facilitate neuromuscular transmission. Biological chemistry Hoppe-Seyler, 373 (8). pp. 707-714. ISSN 0177-3593 (https://doi.org/10.1515/bchm3.1992.373.2.707)

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Abstract

The dendrotoxins are a homologous group of potassium channel-blocking polypeptides found in mamba snake venom. They are similar in sequence and structure to Kunitz-type serine protease inhibitors. Modified and native protease inhibitors were assayed for dendrotoxin-like activity using radioligand-binding and twitch tension-recording methods. Despite the large number and high concentration of compounds tested, no protease inhibitor displayed dendrotoxin-like activity. The results indicate that the protease-inhibiting and potassium channel-blocking activities of these two groups of polypeptides are not linked.

  • Item type:Article
    ID code:31675
    Dates:
    Date
    Event
    1992
    Published
    Keywords:amino acid sequence, animals, chickens, elapid venoms, iodine radioisotopes, kinetics, membranes, molecular sequence data, muscle contraction, neuromuscular junction, potassium channels, protease inhibitors, radioligand assay, rats, cholinergic receptors, structure-activity relationship, synaptic transmission, synaptosomes, Biochemistry
    Subjects:UNSPECIFIED
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:13 Jul 2011 08:56
    Last modified:01 Dec 2022 01:52
    URI:https://strathprints.strath.ac.uk/id/eprint/31675
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