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2024

Hryczanek, Heather F. and Barrett, John and Barrett, Tim N. and Burley, Glenn A. and Cookson, Rosa E. and Hatley, Richard J. D. and Measom, Nicholas D. and Roper, James A. and Rowedder, James E. and Slack, Robert J. and Śmieja, Connor B. and Macdonald, Simon J. F. (2024) Core modifications of GSK3335103 toward orally bioavailable αvβ6 inhibitors with improved synthetic tractability. Journal of Medicinal Chemistry, 67 (21). pp. 19689-19715. ISSN 0022-2623

2023

Bradley, Erin and Fusani, Lucia and Chung, Chun-wa and Craggs, Peter D. and Demont, Emmanuel H. and Humphreys, Philip G. and Mitchell, Darren J. and Phillipou, Alexander and Rioja, Inmaculada and Shah, Rishi R. and Wellaway, Christopher R. and Prinjha, Rab K. and Palmer, David S. and Kerr, William J. and Reid, Marc and Wall, Ian D. and Cookson, Rosa (2023) Structure-guided design of a domain-selective bromodomain and extra terminal N-terminal bromodomain chemical probe. Journal of Medicinal Chemistry, 66 (23). pp. 15728-15749. ISSN 0022-2623

2022

Humphreys, Philip G. and Anderson, Niall A. and Bamborough, Paul and Baxter, Andrew and Chung, Chun-wa and Cookson, Rosa and Craggs, Peter D. and Dalton, Toryn and Fournier, Julie C. L. and Gordon, Laurie J. and Gray, Heather F. and Gray, Matthew W. and Gregory, Richard and Hirst, David J. and Jamieson, Craig and Jones, Katherine L. and Kessedjian, Hripsimee and Lugo, David and McGonagle, Grant and Patel, Vipulkumar K. and Patten, Christopher and Poole, Darren L. and Prinjha, Rab K. and Ramirez-Molina, Cesar and Rioja, Inmaculada and Seal, Gail and Stafford, Kayleigh A. J. and Shah, Rishi R. and Tape, Daniel and Theodoulou, Natalie H. and Tomlinson, Laura R. and Ukuser, Sabri and Wall, Ian D. and Wellaway, Natalie and White, Gemma (2022) Identification and optimization of a ligand-efficient benzoazepinone bromodomain and extra terminal (BET) family acetyl-lysine mimetic into the oral candidate quality molecule I-BET432. Journal of Medicinal Chemistry, 65 (22). pp. 15174-15207. ISSN 0022-2623

Clark, Jennifer M. and Salgado-Polo, Fernando and Macdonald, Simon J. F. and Barrett, Tim N. and Perrakis, Anastassis and Jamieson, Craig (2022) Structure-based design of a novel class of autotaxin inhibitors based on endogenous allosteric modulators. Journal of Medicinal Chemistry, 65 (8). 6338–6351. ISSN 0022-2623

Humphreys, Philip G. and Atkinson, Stephen J. and Bamborough, Paul and Bit, Rino A. and Chung, Chun-wa and Craggs, Peter D. and Cutler, Leanne and Davis, Rob and Ferrie, Alan and Gong, GangLi and Gordon, Laurie J. and Gray, Matthew and Harrison, Lee A. and Hayhow, Thomas G. and Haynes, Andrea and Henley, Nick and Hirst, David J. and Holyer, Ian D. and Lindon, Matthew J. and Lovatt, Cerys and Lugo, David and McCleary, Scott and Molnar, Judit and Osmani, Qendresa and Patten, Chris and Preston, Alex and Rioja, Inmaculada and Seal, Jonathan T. and Smithers, Nicholas and Sun, Fenglai and Tang, Dalin and Taylor, Simon and Theodoulou, Natalie H. and Thomas, Clare and Watson, Robert J. and Wellaway, Christopher R. and Zhu, Linrong and Tomkinson, Nicholas C. O. and Prinjha, Rab K. (2022) Design, synthesis, and characterization of I-BET567, a pan-bromodomain and extra terminal (BET) bromodomain oral candidate. Journal of Medicinal Chemistry, 65 (3). pp. 2262-2287. ISSN 0022-2623

2021

Giordani, Federica and Khalaf, Abedawn I. and Gillingwater, Kirsten and Munday, Jane C. and De Koning, Harry P. and Suckling, Colin J. and Barrett, Michael P. and Scott, Fraser J. (2021) Erratum : novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model (J. Med. Chem. (2019) 62 (6) (3021-3035) DOI: 10.1021/acs.jmedchem.8b01847). Journal of Medicinal Chemistry, 64 (24). 18236. ISSN 0022-2623

Tse, Edwin G. and Aithani, Laksh and Anderson, Mark and Cardoso-Silva, Jonathan and Cincilla, Giovanni and Conduit, Gareth J. and Galushka, Mykola and Guan, Davy and Hallyburton, Irene and Irwin, Benedict W. J. and Kirk, Kiaran and Lehane, Adele M. and Lindblom, Julia C. R. and Lui, Raymond and Matthews, Slade and McCulloch, James and Motion, Alice and Ng, Ho Leung and Öeren, Mario and Robertson, Murray N. and Spadavecchio, Vito and Tatsis, Vasileios A. and van Hoorn, Willem P. and Wade, Alexander D. and Whitehead, Thomas M. and Willis, Paul and Todd, Matthew H. (2021) An open drug discovery competition : experimental validation of predictive models in a series of novel antimalarials. Journal of Medicinal Chemistry, 64 (22). pp. 16450-16463. ISSN 0022-2623

Lucas, Simon C. C. and Atkinson, Stephen J and Chung, Chun-Wa and Davis, Rob and Gordon, Laurie and Grandi, Paola and Gray, James J R and Grimes, Thomas and Phillipou, Alexander and Preston, Alex G and Prinjha, Rab K and Rioja, Inmaculada and Taylor, Simon and Tomkinson, Nicholas C. O. and Wall, Ian and Watson, Robert J and Woolven, James and Demont, Emmanuel H (2021) Optimization of a series of 2,3-dihydrobenzofurans as highly potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitors. Journal of Medicinal Chemistry, 64 (15). pp. 10711-10741. ISSN 0022-2623

Abdel-Maksoud, Mohammed and El-Gamal, Mohammed I. and Lee, Bong S. and Gamal El-Din, Mahmoud M. and Jeon, Hong R. and Kwon, Dow and Ammar, Usama M. and Mersal, Karim I. and Ali, Eslam M. H. and Lee, Kyung-Tae and Yoo, Kyung Ho and Han, Dong Keun and Lee, Jae Kyun and Kim, Garam and Choi, Hong Seok and Kwon, Young Jik and Lee, Kwan Hyi and Oh, Chang-Hyun (2021) Discovery of new Imidazo[2,1‑b]thiazole derivatives as potent pan-RAF inhibitors with promising in vitro and in vivo anti-melanoma activity. Journal of Medicinal Chemistry, 64 (10). pp. 6877-6901. ISSN 0022-2623

2020

Wellaway, Christopher R. and Bamborough, Paul and Bernard, Sharon G. and Chung, Chun-wa and Craggs, Peter D. and Cutler, Leanne and Demont, Emmanuel H. and Evans, John P. and Gordon, Laurie and Karamshi, Bhumika and Lewis, Antonia J. and Lindon, Matthew J. and Mitchell, Darren J. and Rioja, Inmaculada and Soden, Peter E. and Taylor, Simon and Watson, Robert J. and Willis, Rob and Woolven, James M. and Wyspiańska, Beata S. and Kerr, William J. and Prinjha, Rab K. (2020) Structure-based design of a bromodomain and extraterminal domain (BET) inhibitor selective for the N-terminal bromodomains that retains an anti-inflammatory and antiproliferative phenotype. Journal of Medicinal Chemistry, 63 (17). pp. 9020-9044. ISSN 0022-2623

Clegg, Michael A. and Bamborough, Paul and Chung, Chun-wa and Craggs, Peter D. and Gordon, Laurue and Grandi, Paola and Leveridge, Melanie and Lindon, Matthew and Liwicki, Gemma M. and Michon, Anne-Marie and Molnar, Judit and Rioja, Inmaculada and Soden, Peter E. and Theodoulou, Natalie H. and Werner, Thilo and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2020) Application of atypical acetyl-lysine methyl mimetics in the development of selective inhibitors of the bromodomain-containing protein 7 (BRD7)/bromodomain-containing protein 9 (BRD9) bromodomains. Journal of Medicinal Chemistry, 63 (11). pp. 5816-5840. ISSN 0022-2623

Lucas, Simon C. C. and Atkinson, Stephen J. and Bamborough, Paul and Barnett, Heather and Chung, Chun-wa and Gordon, Laurie and Mitchell, Darren J. and Phillipou, Alexander and Prinjah, Rab K. and Sheppard, Robert J. and Tomkinson, Nicholas C. O. and Watson, Robert J. and Demont, Emmanuel H. (2020) The optimization of potent ATAD2 and CECR2 bromodomain inhibitors with an atypical binding mode. Journal of Medicinal Chemistry, 63 (10). pp. 5212-5241. ISSN 0022-2623

Borthwick, Jennifer A. and Alemparte, Carlos and Wall, Ian and Whitehurst, Benjamin C. and Argyrou, Argyrides and Burley, Glenn and de Dios-Anton, Paco and Guijarro, Laura and Monteiro, Maria Candida and Ortega, Fatima and Suckling, Colin J and Pichel, Julia Castro and Cacho, Monica and Young, Robert J. (2020) Mycobacterium tuberculosis decaprenylphosphoryl-β- d-ribose oxidase inhibitors : expeditious reconstruction of suboptimal hits into a series with potent in vivo activity. Journal of Medicinal Chemistry, 63 (5). pp. 2557-2576. ISSN 0022-2623

2019

Barrett, Tim N. and Taylor, Jonathan A. and Barker, Daniel and Procopiou, Panayiotis A. and Thompson, James D. F. and Barrett, John and Le, Joelle and Lynn, Sean M. and Pogany, Peter and Pratley, Cassie and Pritchard, John M. and Roper, James A. and Rowedder, James E. and Slack, Robert J. and Vitulli, Giovanni and Macdonald, Simon J. F. and Kerr, William J. (2019) Profile of a highly selective quaternized pyrrolidine betaine αvβ6 integrin inhibitor - (3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate synthesized by stereoselective methylation. Journal of Medicinal Chemistry, 62 (16). pp. 7543-7556. ISSN 0022-2623

Adams, David R. and Tawati, Salha and Berretta, Giacomo and Rivas, Paula Lopez and Baiget, Jessica and Jiang, Zhong and Alsfouk, Aisha and MacKay, Simon P. and Pyne, Nigel J. and Pyne, Susan (2019) Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2. Journal of Medicinal Chemistry, 62 (7). pp. 3658-3676. ISSN 0022-2623

Giordani, Federica and Khalaf, Abedawn I. and Gillingwater, Kirsten and Munday, Jane C. and De Koning, Harry P. and Suckling, Colin J. and Barrett, Michael P. and Scott, Fraser J. (2019) Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model. Journal of Medicinal Chemistry, 62 (6). pp. 3021-3035. ISSN 0022-2623

2017

Anthony, Nahoum G. and Baiget, Jessica and Berretta, Giacomo and Boyd, Marie and Breen, David and Edwards, Joanne and Gamble, Carly and Gray, Alexander I. and Harvey, Alan L. and Hatziieremia, Sophia and Ho, Ka Ho and Huggan, Judith K. and Lang, Stuart and Llona-Minguez, Sabin and Luo, Jia Lin and McIntosh, Kathryn and Paul, Andrew and Plevin, Robin J. and Robertson, Murray N. and Scott, Rebecca and Suckling, Colin J. and Sutcliffe, Oliver Brook and Young, Louise C. and MacKay, Simon P. (2017) Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers. Journal of Medicinal Chemistry, 60 (16). pp. 7043-7066. ISSN 0022-2623

Keune, Willem-Jan and Potjewyd, Frances and Heidebrecht, Tatjana and Salgado-Polo, Fernando and Macdonald, Simon J. F. and Chelvarajan, Lakshman and Abdel Latif, Ahmed and Soman, Sony and Morris, Andrew J. and Watson, Allan J. B. and Jamieson, Craig and Perrakis, Anastassis (2017) Rational design of autotaxin inhibitors by structural evolution of endogenous modulators. Journal of Medicinal Chemistry, 60 (5). pp. 2006-2017. ISSN 0022-2623

Miller, Lisa M. and Pritchard, John M. and Macdonald, Simon J. F. and Jamieson, Craig and Watson, Allan J. B. (2017) Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins. Journal of Medicinal Chemistry, 60 (8). ISSN 0022-2623

Miller, Lisa M. and Keune, Willem-Jan and Castagna, Diana and Young, Louise C. and Duffy, Emma L. and Potjewyd, Frances and Salgado-Polo, Fernando and Garcia, Paloma Engel and Semaan, Dima and Pritchard, John M. and Perrakis, Anastassis and Macdonald, Simon J. F. and Jamieson, Craig and Watson, Allan J. B. (2017) Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode. Journal of Medicinal Chemistry, 60 (2). pp. 722-748. ISSN 0022-2623

2016

Amour, Augustin and Barton, Nick and Cooper, Anthony W.J. and Inglis, Graham and Jamieson, Craig and Luscombe, Christopher N. and Perez, David and Peace, Simon and Rowland, Paul and Tame, Chris and Uddin, Sorif and Vitulli, Giovanni and Wellaway, Natalie (2016) Evolution of a novel orally bioavailable series of PI3Kδ inhibitors from an inhaled lead for the treatment of respiratory disease. Journal of Medicinal Chemistry. ISSN 0022-2623

Borthwick, Jennifer A. and Ancellin, Nicolas and Bertrand, Sophie M. and Bingham, Ryan P. and Carter, Paul S. and Chung, Chun-wa and Churcher, Ian and Dodic, Nerina and Fournier, Charlène and Francis, Peter L. and Hobbs, Andrew and Jamieson, Craig and Pickett, Stephen D. and Smith, Sarah E. and Somers, Donald O'N. and Spitzfaden, Claus and Suckling, Colin J. and Young, Robert J. (2016) Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening. Journal of Medicinal Chemistry, 59 (6). pp. 2452-2467. ISSN 0022-2623

Westaway, Susan M. and Preston, Alex G. S. and Barker, Michael D. and Brown, Fiona and Brown, Jack A. and Campbell, Matthew and Chung, Chun-Wa and Drewes, Gerard and Eagle, Robert and Garton, Neil and Gordon, Laurie and Haslam, Carl and Hayhow, Thomas G. and Humphreys, Philip G. and Joberty, Gerard and Katso, Roy and Kruidenier, Laurens and Leveridge, Melanie and Pemberton, Michelle and Rioja, Inma and Seal, Gail A. and Shipley, Tracy and Singh, Onkar and Suckling, Colin J. and Taylor, Joanna and Thomas, Pamela and Wilson, David M. and Lee, Kevin and Prinjha, Rab K. (2016) Cell penetrant inhibitors of the KDM4 and KDM5 families of histone lysine demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one derivatives. Journal of Medicinal Chemistry, 59 (4). pp. 1370-1387. ISSN 0022-2623

Theodoulou, Natalie H. and Bamborough, Paul and Bannister, Andrew J. and Becher, Isabelle and Bit, Rino A. and Che, Ka Hing and Chung, Chun-wa and Dittmann, Antje and Drewes, Gerard and Drewy, David H. and Gordon, Laurie and Grandi, Paola and Leveridge, Melanie and Lindon, Matthew and Michon, Anne-Marie and Molnar, Judit and Robson, Samuel C. and Tomkinson, Nicholas C. O. and Kouzarides, Tony and Prinjha, Rab K. and Humphreys, Philip G. (2016) The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. Journal of Medicinal Chemistry, 59 (4). pp. 1425-1439. ISSN 0022-2623

2015

Zmuda, Filip and Malviya, Gaurav and Blair, Adele and Boyd, Marie and Chalmers, Anthony J. and Sutherland, Andrew and Pimlott, Sally L. (2015) Synthesis and evaluation of a radioiodinated tracer with specificity for poly(ADP-ribose) polymerase-1 (PARP-1) in vivo. Journal of Medicinal Chemistry, 58 (21). pp. 8683-8693. ISSN 0022-2623

Bertrand, Sophie M. and Ancellin, Nicolas and Beaufils, Benjamin and Bingham, Ryan P. and Borthwick, Jennifer A. and Boullay, Anne Bénédicte and Boursier, Eric and Carter, Paul S. and Chung, Chun Wa and Churcher, Ian and Dodic, Nerina and Fouchet, Marie Hélène and Fournier, Charlène and Francis, Peter L. and Gummer, Laura A. and Herry, Kenny and Hobbs, Andrew and Hobbs, Clare I. and Homes, Paul and Jamieson, Craig and Nicodeme, Edwige and Pickett, Stephen D. and Reid, Iain H. and Simpson, Graham L. and Sloan, Lisa A. and Smith, Sarah E. and Somers, Donald O N and Spitzfaden, Claus and Suckling, Colin J. and Valko, Klara and Washio, Yoshiaki and Young, Robert J. (2015) The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits. Journal of Medicinal Chemistry, 58 (18). pp. 7140-7163. ISSN 0022-2623

2014

Khalaf, Abedawn I and Huggan, Judith and Suckling, Colin J and Gibson, Colin L and Stewart, Kirsten and Giordani, Federica and Barrett, Michael P. and Wong, Pui Ee and Barrack, Keri L and Hunter, William N (2014) Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57 (15). pp. 6479-6494. ISSN 0022-2623

2013

Baek, Dong Jae and MacRitchie, Neil and Anthony, Nahoum G and Mackay, Simon P and Pyne, Susan and Pyne, Nigel J and Bittman, Robert (2013) Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. Journal of Medicinal Chemistry, 56 (22). pp. 9310-9327. ISSN 0022-2623

Talapatra, Sandeep K. and Anthony, Nahoum Guillaume Hsuan and MacKay, Simon and Kozielski, Frank (2013) The mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism. Journal of Medicinal Chemistry, 56 (16). pp. 6317-6329. ISSN 0022-2623

Trump, Ryan P. and Bresciani, Stefano and Cooper, Anthony W. J. and Tellam, James P. and Wojno, Justyna and Blaikley, John and Orband-Miller, Lisa A. and Kashatus, Jennifer A. and Boudjelal, Mohamed and Dawson, Helen C. and Loudon, Andrew and Ray, David and Grant, Daniel and Farrow, Stuart N. and Willson, Timothy M. and Tomkinson, Nicholas C. O. (2013) Optimized chemical probes for REV-ERB alpha. Journal of Medicinal Chemistry, 56 (11). pp. 4729-4737. ISSN 0022-2623

Good, James A. D. and Wang, Fang and Rath, Oliver and Kaan, Hung Yi Kristal and Talapatra, Sandeep K. and Podgorski, Dawid and MacKay, Simon P. and Kozielski, Frank (2013) Optimized s-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. Journal of Medicinal Chemistry, 56 (5). pp. 1878-1893. ISSN 0022-2623

Viswanath, AN and Pae, AN and MacKay, Simon (2013) Resistance by allostery: a novel perspective for Eg5-targeted drug design. Journal of Medicinal Chemistry. ISSN 0022-2623

Al-Riyami, Lamyaa and Pineda, Miguel and Rzepecka, Justyna and Huggan, Judith and Khalaf, Abedawn and Suckling, Colin and Rodgers, David and Harnett, Margaret and Harnett, William and Scott, Fraser (2013) Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis : Helminth-based synthetic compound protects against CIA. Journal of Medicinal Chemistry, 56. pp. 9982-10002. ISSN 0022-2623

2012

Fomovska, Alina and Wood, Richard D. and Mui, Ernest and Dubey, Jitenter P. and Ferreira, Leandra R. and Hickman, Mark R. and Lee, Patricia J. and Leed, Susan E. and Auschwitz, Jennifer M. and Welsh, William J. and Sommerville, Caroline and Woods, Stuart and Roberts, Craig and Mcleod, Rima (2012) Salicylanilide inhibitors of toxoplasma gondii. Journal of Medicinal Chemistry, 55 (19). pp. 8375-8391. ISSN 0022-2623

Wang, F. and Good, J. A. D. and Rath, O. and Kaan, H. Y. K. and Sutcliffe, O. B. and Mackay, S. P. and Kozielski, F. (2012) Triphenylbutanamines : kinesin spindle protein inhibitors with in vivo antitumor activity. Journal of Medicinal Chemistry, 55 (4). pp. 1511-1525. ISSN 0022-2623

2011

Dover, Lynn G. and Coxon, Geoffrey (2011) Currrent status and research strategies in tuberculosis drug development. Journal of Medicinal Chemistry, 54 (18). 6157–6165. ISSN 0022-2623

2010

Grove, Simon J .A. and Jamieson, Craig and Maclean, John K. F. and Morrow, John A. and Rankovic, Zoran (2010) Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Journal of Medicinal Chemistry, 53 (20). pp. 7271-7279. ISSN 0022-2623

Tulloch, Lindsay B. and Martini, Viviane P. and Iulek, Jorge and Huggan, J. and Lee, Jeong Hwan and Gibson, C.L. and Smith, Terry K. and Suckling, C.J. and Hunter, William N. (2010) Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. Journal of Medicinal Chemistry, 53 (1). pp. 221-229. ISSN 0022-2623

Tipparaju, Suresh K and Muench, Stephen P and Mui, Ernest J and Ruzheinikov, Sergey N and Lu, Jeffrey Z. and Hutson, Samuel L and Kirisits, Michael J. and Prigge, Sean T. and Roberts, Craig and Henriquez, Fiona L and Kozikowski, Alan P and Rice, David W and McLeod, Rima L (2010) Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. Journal of Medicinal Chemistry, 53 (17). pp. 6287-6300.

2009

Coxon, Geoffrey D. and Furman, Brian L. and Harvey, Alan L. and McTavish, John and Mooney, Mark H. and Arastoo, Mahmoud and Kennedy, A.R. and Tettey, J.N.A. and Waigh, R.D. (2009) Benzylguanidines and other galegine analogues inducing weight loss in mice. Journal of Medicinal Chemistry, 52 (11). pp. 3457-3463. ISSN 0022-2623

Krause-Heuer, A.M. and Grunert, R. and Kuhne, S. and Maruszak, M. and Wheate, N.J. and Le Pevelen, D. and Boag, L.R. and Fisher, D.M. (2009) Studies into the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells. Journal of Medicinal Chemistry, 52 (17). pp. 5474-5484. ISSN 0022-2623

2008

Kemp, S. and Wheate, N.J. and Pisani, Michelle J. and Aldrich-Wright, J.R. (2008) Degradation of bidentate-coordinated platinum(II)-based DNA intercalators by reduced l-glutathione. Journal of Medicinal Chemistry, 51 (9). pp. 2787-2794. ISSN 0022-2623

2007

Anthony, Nahoum Guillaume Hsuan and Breen, D. and Clarke, Joanna and Donoghue, Gavin and Drummond, Allan J. and Ellis, Elizabeth and Gemmell, Curtis G. and Helesbeux, Jean-Jacques and Hunter, Iain. S. and Khalaf, Abedawn and MacKay, Simon and Parkinson, J.A. and Suckling, C.J. and Waigh, R.D. (2007) Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups. Journal of Medicinal Chemistry, 50 (24). pp. 6116-6125. ISSN 0022-2623

Woo, L.W.L. and Bubert, C. and Sutcliffe, O.B. and Smith, A. and Chander, S.K. and Mahon, M.F. and Purohit, A. and Reed, M.J. and Potter, B.V.L. (2007) Dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry, 50 (15). pp. 3540-3560. ISSN 0022-2623

2006

Habtemariam, Abraha and Melchart, Michael and Fernandez, Rafael and Parsons, Simon and Oswald, Iain D. H. and Parkin, Andrew and Fabbiani, Francesca P. A. and Davidson, James E. and Dawson, Alice and Aird, Rhona E. and Jodrell, Duncan I. and Sadler, Peter J. (2006) Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. Journal of Medicinal Chemistry, 49 (23). pp. 6858-6868. ISSN 0022-2623

2005

Corea, G. and Fattorusso, E. and Lanzotti, V. and Di Meglio, P. and Maffia, P. and Grassia, G. and Ialenti, A. and Ianaro, A. (2005) Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. Journal of Medicinal Chemistry, 48 (22). pp. 7055-7062. ISSN 0022-2623

2004

Khalaf, A.I. and Waigh, R.D. and Drummond, A.J. and Pringle, B. and McGroarty, I. and Skellern, G.G. and Suckling, C.J. (2004) Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity. Journal of Medicinal Chemistry, 47 (8). pp. 2133-2156. ISSN 0022-2623

2003

Woo, L.W.L. and Sutcliffe, O.B. and Bubert, C. and Grasso, A. and Chander, S.K. and Purohit, A. and Reed, M.J. and Potter, B.V.L. (2003) First dual aromatase-steroid sulfatase inhibitors. Journal of Medicinal Chemistry, 46 (15). pp. 3193-3196. ISSN 0022-2623

2000

Khalaf, A.I. and Pitt, A.R. and Scobie, M. and Suckling, C.J. and Urwin, J. and Waigh, R.D. and Young, S.C. and Fishleigh, R.V. and Fox, K.R. (2000) DNA Binding, Solubility, and Partitioning Characteristics of Extended Lexitropsins. Journal of Medicinal Chemistry, 43 (17). pp. 3257-3266. ISSN 0022-2623

1997

McKenna, M T and Proctor, G R and Young, L C and Harvey, A L (1997) Novel tacrine analogues for potential use against Alzheimer's disease : potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Journal of Medicinal Chemistry, 40 (22). pp. 3516-3523. ISSN 0022-2623