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2024

Tipping, William J. and Wilson, Liam T. and Tomkinson, Nicholas C. O. and Faulds, Karen and Graham, Duncan (2024) Label-free screening of drug-induced liver injury using stimulated Raman scattering microscopy and spectral phasor analysis. Analytical Chemistry, 96 (26). pp. 10639-10647. ISSN 0003-2700

Rianjongdee, Francesco and Palmer, David and Pickett, Stephen D. and Pogány, Peter and Tomkinson, Nicholas C.O. and Green, Darren V.S. (2024) bbSelect : an open-source tool for performing a 3D pharmacophore-driven diverse selection of R-groups. Journal of Chemical Information and Modeling, 64 (12). pp. 4687-4699. ISSN 1549-9596

Grunshaw, Thomas and Wood, Susanna H. and Sproules, Stephen and Parrott, Andrew and Nordon, Alison and Shapland, Peter D. P. and Wheelhouse, Katherine M. P. and Tomkinson, Nicholas C. O. (2024) A mechanistic investigation of the N-hydroxyphthalimide catalyzed benzylic oxidation mediated by sodium chlorite. Journal of Organic Chemistry, 89 (11). pp. 7933-7945. ISSN 0022-3263

2023

Murphy, Neville and Tipping, William J. and Braddick, Henry J. and Wilson, Liam T. and Tomkinson, Nicholas C.O. and Faulds, Karen and Graham, Duncan and Farràs, Pau (2023) Expanding the range of bioorthogonal tags for multiplex stimulated Raman scattering microscopy. Angewandte Chemie International Edition, 62 (48). e202311530. ISSN 1521-3773

Salaun, Christine and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2023) The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins. Journal of Biological Chemistry, 299 (10). 105201. ISSN 1083-351X

Mason, Joseph and Wilders, Harry and Fallon, David J. and Thomas, Ross P. and Bush, Jacob T. and Tomkinson, Nicholas C. O. and Rianjongdee, Francesco (2023) Automated LC-MS analysis and data extraction for high-throughput chemistry. Digital Discovery, 2 (6). pp. 1894-1899. ISSN 2635-098X

Cosgrove, Brett and Grant, Emma K. and Bertrand, Sophie and Down, Kenneth D. and Somers, Don O. and P. Evans, John and Tomkinson, Nicholas C. O. and Barker, Michael D. (2023) Covalent targeting of non-cysteine residues in PI4KIIIβ. RSC Chemical Biology, 4 (12). pp. 1111-1122. ISSN 2633-0679

Aatkar, Arron and Vuorinen, Aini and Longfield, Oliver E. and Gilbert, Katharine and Peltier-Heap, Rachel and Wagner, Craig D. and Zappacosta, Francesca and Rittinger, Katrin and Chung, Chun-wa and House, David and Tomkinson, Nicholas C. O. and Bush, Jacob T. (2023) Efficient ligand discovery using sulfur(VI) fluoride reactive fragments. ACS Chemical Biology, 18 (9). pp. 1926-1937. ISSN 1554-8937

Fallon, David J. and Phillipou, Alex and Schofield, Christopher J. and House, David and Tomkinson, Nicholas C. O. and Bush, Jacob T. (2023) Photoaffinity labelling displacement assay using multiple recombinant protein domains. Biochemical Journal, 480 (15). pp. 1183-1197. ISSN 0264-6021

Maciuk, Sergej and Wood, Susanna H. and Patel, Vipulkumar K. and Shapland, Peter D. P. and Tomkinson, Nicholas C. O. (2023) Peracid oxidation of unactivated sp3 C—H bonds : an important solvent effect. Chemistry - A European Journal, 29 (31). e202204007. ISSN 1521-3765

Leventi, Aristea Anna and Braddick, Henry J. and Billimoria, Kharmen and Wallace, Gregory Q. and Goenaga-Infante, Heidi and Tomkinson, Nicholas C.O. and Faulds, Karen and Graham, Duncan (2023) Synthesis, characterisation and multi-modal intracellular mapping of cisplatin nano-conjugates. Chemical Communications, 59 (42). pp. 6395-6398. ISSN 1359-7345

Braddick, Henry J. and Tipping, William J. and Wilson, Liam T. and Jaconelli, Harry S. and Grant, Emma K. and Faulds, Karen and Graham, Duncan and Tomkinson, Nicholas C. O. (2023) Determination of intracellular esterase activity using ratiometric Raman sensing and spectral phasor analysis. Analytical Chemistry, 95 (12). 5369–5376. ISSN 0003-2700

Thomas, Ross P. and Grant, Emma K. and Dickinson, Eleanor R. and Zappacosta, Francesca and Edwards, Lee J. and Hann, Michael M. and House, David and Tomkinson, Nicholas C. O. and Bush, Jacob T. (2023) Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry. RSC Medicinal Chemistry, 14 (4). pp. 671-679. ISSN 2632-8682

Butler, Liam and Locatelli, Carolina and Allagioti, Despoina and Lousa, Irina and Lemonidis, Kimon and Tomkinson, Nicholas C. O. and Salaun, Christine and Chamberlain, Luke H. (2023) S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction. Journal of Biological Chemistry, 299 (1). 102754. ISSN 1083-351X

2022

Salaun, Christine and Takizawa, Hiroya and Galindo, Alex and Munro, Kevin R. and McLellan, Jayde and Sugimoto, Isamu and Okino, Tomotaka and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2022) Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation. Journal of Biological Chemistry, 298 (10). 102469. ISSN 1083-351X

Tipping, William J. and Merchant, Andrew S. and Fearon, Rebecca and Tomkinson, Nicholas C. O. and Faulds, Karen and Graham, Duncan (2022) Temporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture system. RSC Chemical Biology, 3 (9). pp. 1154-1164. ISSN 2633-0679

Tipping, William J. and Wilson, Liam T. and An, Connie and Leventi, Aristea A. and Wark, Alastair W. and Wetherill, Corinna and Tomkinson, Nicholas C. O. and Faulds, Karen and Graham, Duncan (2022) Stimulated Raman scattering microscopy with spectral phasor analysis : applications in assessing drug-cell interactions. Chemical Science, 13 (12). pp. 3468-3476. ISSN 2041-6539

Romartinez-Alonso, Beatriz and Agostini, Maura and Jones, Heulyn and McLellan, Jayde and Sood, Deepali and Tomkinson, Nicholas and Marelli, Federica and Gentile, Ilaria and Visser, W. Edward and Schoenmakers, Erik and Fairall, Louise and Privalsky, Martin and Moran, Carla and Persani, Luca and Chatterjee, Krishna and Schwabe, John (2022) Structure-guided approach to relieving transcriptional repression inResistance to Thyroid Hormone α. Molecular and Cellular Biology, 42 (2). e00363. ISSN 0270-7306

Humphreys, Philip G. and Atkinson, Stephen J. and Bamborough, Paul and Bit, Rino A. and Chung, Chun-wa and Craggs, Peter D. and Cutler, Leanne and Davis, Rob and Ferrie, Alan and Gong, GangLi and Gordon, Laurie J. and Gray, Matthew and Harrison, Lee A. and Hayhow, Thomas G. and Haynes, Andrea and Henley, Nick and Hirst, David J. and Holyer, Ian D. and Lindon, Matthew J. and Lovatt, Cerys and Lugo, David and McCleary, Scott and Molnar, Judit and Osmani, Qendresa and Patten, Chris and Preston, Alex and Rioja, Inmaculada and Seal, Jonathan T. and Smithers, Nicholas and Sun, Fenglai and Tang, Dalin and Taylor, Simon and Theodoulou, Natalie H. and Thomas, Clare and Watson, Robert J. and Wellaway, Christopher R. and Zhu, Linrong and Tomkinson, Nicholas C. O. and Prinjha, Rab K. (2022) Design, synthesis, and characterization of I-BET567, a pan-bromodomain and extra terminal (BET) bromodomain oral candidate. Journal of Medicinal Chemistry, 65 (3). pp. 2262-2287. ISSN 0022-2623

2021

Fallon, David J. and Lehmann, Stephanie and Chung, Chun-Wa and Phillipou, Alex and Eberl, Christian and Fantom, Ken G. M. and Zappacosta, Francesca and Patel, Vipulkumar K. and Bantscheff, Marcus and Schofield, Christopher J. and Tomkinson, Nicholas C. O. and Bush, Jacob T. (2021) One-step synthesis of photoaffinity probes for live-cell MS-based proteomics. Chemistry - A European Journal, 27 (71). pp. 17880-17888. ISSN 1521-3765

Thomas, Ross P. and Heap, Rachel E. and Zappacosta, Francesca and Grant, Emma K. and Pogány, Peter and Besley, Stephen and Fallon, David J. and Hann, Michael M. and House, David and Tomkinson, Nicholas C. O. and Bush, Jacob T. (2021) A direct-to-biology high-throughput chemistry approach to reactive fragment screening. Chemical Science, 12 (36). pp. 12098-12106. ISSN 2041-6539

Wilson, Liam T. and Tipping, William J. and Wetherill, Corinna and Henley, Zoë and Faulds, Karen and Graham, Duncan and Mackay, Simon P. and Tomkinson, Nicholas C. O. (2021) Mitokyne : a ratiometric raman probe for mitochondrial pH. Analytical Chemistry, 93 (37). pp. 12786-12792. ISSN 0003-2700

Fournier, Julie C. L. and Evans, John P. and Zappacosta, Francesca and Thomas, Daniel A. and Patel, Vipulkumar K. and White, Gemma V. and Campos, Sebastien and Tomkinson, Nicholas C. O. (2021) Acetylation of the catalytic lysine inhibits kinase activity in PI3Kδ. ACS Chemical Biology, 16 (9). pp. 1644-1653. ISSN 1554-8937

Lucas, Simon C. C. and Atkinson, Stephen J and Chung, Chun-Wa and Davis, Rob and Gordon, Laurie and Grandi, Paola and Gray, James J R and Grimes, Thomas and Phillipou, Alexander and Preston, Alex G and Prinjha, Rab K and Rioja, Inmaculada and Taylor, Simon and Tomkinson, Nicholas C. O. and Wall, Ian and Watson, Robert J and Woolven, James and Demont, Emmanuel H (2021) Optimization of a series of 2,3-dihydrobenzofurans as highly potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitors. Journal of Medicinal Chemistry, 64 (15). pp. 10711-10741. ISSN 0022-2623

Clegg, Michael A. and Theodoulou, Natalie H. and Bamborough, Paul and Chung, Chun-wa and Craggs, Peter D. and Demont, Emmanuel H. and Gordon, Laurie J. and Liwicki, Gemma M. and Phillipou, Alex and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2021) Optimization of naphthyridones into selective TATA-binding protein associated factor 1 (TAF1) bromodomain inhibitors. ACS Medicinal Chemistry Letters, 12 (8). pp. 1308-1317. ISSN 1948-5875

Thomas, Ross P. and Heap, Rachel E. and Zappacosta, Francesca and Grant, Emma K. and Pogany, Peter and Besley, Stephen and Fallon, David J. and Hann, Michael M. and House, David and Tomkinson, Nick C. O. and Bush, Jacob T. (2021) A direct-to-biology high-throughput chemistry approach to reactive fragment screening. Other. ChemRxiv, Cambridge.

Cosgrove, Brett and Down, Kenneth and Bertrand, Sophie and Tomkinson, Nicholas C.O. and Barker, Michael D. (2021) Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,​5-​bicyclic heterocycles. Bioorganic and Medicinal Chemistry Letters, 33. 127752. ISSN 0960-894X

Davidson, Stuart C. and dos Passos Gomes, Gabriel and Kuhn, Leah R. and Alabugin, Igor V. and Kennedy, Alan and Tomkinson, Nick C.O. (2021) Organocatalytic sulfoxidation. Tetrahedron, 78. 131784. ISSN 0040-4020

2020

Tipping, William J. and Wilson, Liam T. and Blaseio, Sonja K. and Tomkinson, Nick C O and Faulds, Karen and Graham, Duncan (2020) Ratiometric sensing of fluoride ions using Raman spectroscopy. Chemical Communications, 56 (92). pp. 14463-14466. ISSN 1359-7345

Grant, Emma K. and Fallon, David J. and Hann, Michael M. and Fantom, Ken G. M. and Quinn, Chad and Zappacosta, Francesca and Annan, Roland S. and Chung, Chun-wa and Bamborough, Paul and Dixon, David P. and Stacey, Peter and House, David and Patel, Vipulkumar K. and Tomkinson, Nick C. O. and Bush, Jacob T. (2020) A photoaffinity-based fragment screening platform for efficient identification of protein ligands. Angewandte Chemie International Edition, 59 (47). pp. 21096-21105. ISSN 1521-3773

Locatelli, Carolina and Lemonidis, Kimon and Salaun, Christine and Tomkinson, Nicholas C. O. and Chamberlain, Luke H. (2020) Identification of key features required for efficient S-acylation and plasma membrane targeting of Sprouty-2. Journal of Cell Science, 133 (21). jcs249664. ISSN 0021-9533

Patterson, Sarah J.M. and Clark, Peter R. and Williams, Glynn D. and Tomkinson, Nicholas C.O. (2020) An azide and acetylene free synthesis of 1-substituted 1,2,3-triazoles. Tetrahedron Letters, 61 (45). 152483. ISSN 0040-4039

Wilson, Liam T. and Tipping, William J. and Jamieson, Lauren E. and Wetherill, Corinna and Henley, Zoë and Faulds, Karen and Graham, Duncan and MacKay, Simon P. and Tomkinson, Nick C. O. (2020) A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy. Analyst, 145 (15). pp. 5289-5298. ISSN 0003-2654

Clegg, Michael A. and Bamborough, Paul and Chung, Chun-wa and Craggs, Peter D. and Gordon, Laurue and Grandi, Paola and Leveridge, Melanie and Lindon, Matthew and Liwicki, Gemma M. and Michon, Anne-Marie and Molnar, Judit and Rioja, Inmaculada and Soden, Peter E. and Theodoulou, Natalie H. and Werner, Thilo and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2020) Application of atypical acetyl-lysine methyl mimetics in the development of selective inhibitors of the bromodomain-containing protein 7 (BRD7)/bromodomain-containing protein 9 (BRD9) bromodomains. Journal of Medicinal Chemistry, 63 (11). pp. 5816-5840. ISSN 0022-2623

Lucas, Simon C. C. and Atkinson, Stephen J. and Bamborough, Paul and Barnett, Heather and Chung, Chun-wa and Gordon, Laurie and Mitchell, Darren J. and Phillipou, Alexander and Prinjah, Rab K. and Sheppard, Robert J. and Tomkinson, Nicholas C. O. and Watson, Robert J. and Demont, Emmanuel H. (2020) The optimization of potent ATAD2 and CECR2 bromodomain inhibitors with an atypical binding mode. Journal of Medicinal Chemistry, 63 (10). pp. 5212-5241. ISSN 0022-2623

Salaun, Christine and Greaves, Jennifer and Tomkinson, Nicholas C. O. and Chamberlain, Luke H. (2020) The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation. Journal of Biological Chemistry, 295 (21). pp. 7501-7515. ISSN 1083-351X

Clark, Peter R. and Williams, Glynn D. and Hayes, Jerome F. and Tomkinson, Nicholas C. O. (2020) A scalable metal-, azide-, and halogen-free method for the preparation of triazoles. Angewandte Chemie International Edition, 59 (17). pp. 6740-6744. ISSN 1521-3773

Grant, Emma K. and Fallon, David J. and Hann, Michael M. and Fantom, Ken G. M. and Quinn, Chad and Zappacosta, Francesca and Annan, Roland S. and Cheung, Chun-Wa and Bamborough, Paul and Dixon, David P. and Stacey, Peter and House, David and Patel, Vipulkumar K. and Tomkinson, Nick C. O. and Bush, Jacob T. (2020) PhotoAffinity bits : a photoaffinity-based fragment screening platform for efficient identification of protein ligands. Preprint / Working Paper. ChemRxiv, Washington DC.

Curle, Jonathan M. and Perieteanu, Marina C. and Humphreys, Philip G. and Kennedy, Alan R. and Tomkinson, Nick C. O. (2020) Alkene syn- and anti-oxyamination with malonoyl peroxides. Organic Letters, 22 (4). pp. 1659-1664. ISSN 1523-7060

2019

Grant, Emma K. and Fallon, David J. and Eberl, H. Christian and Fantom, Ken G. M. and Zappacosta, Francesca and Messenger, Cassie and Tomkinson, Nicholas C. O. and Bush, Jacob T. (2019) A photoaffinity displacement assay and probes to study the cyclin‐dependent kinase family. Angewandte Chemie International Edition, 58 (48). pp. 17322-17327. ISSN 1521-3773

Chaffey, Dawn R. and Alamillo-Ferrer, Carla and Davies, Thomas E. and Taylor, Stuart H. and Tomkinson, Nicholas C. O. and Graham, Andrew E. (2019) Metal triflate-promoted allylic substitution reactions of cinnamyl alcohol in the presence of orthoesters and acetals. ACS Omega, 4 (14). pp. 15985-15991. ISSN 2470-1343

Radhi, Ohood A. and Davidson, Scott and Scott, Fiona and Zeng, Run X. and Jones, D. Heulyn and Tomkinson, Nick C. O. and Yu, Jun and Chan, Edmond Y.W. (2019) Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death. Journal of Biological Chemistry, 294. pp. 14289-14307. ISSN 1083-351X

Clark, Peter R. and Williams, Glynn D. and Tomkinson, Nicholas C. O. (2019) Copper-catalysed C-H functionalisation gives access to 2-aminobenzimidazoles. Organic and Biomolecular Chemistry, 17 (34). pp. 7943-7955. ISSN 1477-0520

Greaves, Jennifer and Tomkinson, Nicholas C. O.; Linder, Maurine E., ed. (2019) Detection of heterogeneous protein S-acylation in cells. In: Protein Lipidation. Springer, New York, pp. 13-33. ISBN 978-1-4939-9532-5

Clegg, Michael A. and Tomkinson, Nicholas C. O. and Prinjhal, Rab K. and Humphreys, Philip G. (2019) Advancements in the development of non-BET bromodomain chemical probes. ChemMedChem, 14 (4). pp. 362-385. ISSN 1860-7179

2018

Fort, Loic and Batista, José Miguel and Thomason, Peter A. and Spence, Heather J. and Whitelaw, Jamie A. and Tweedy, Luke and Greaves, Jennifer and Martin, Kirsty J. and Anderson, Kurt I. and Brown, Peter and Lilla, Sergio and Neilson, Matthew P. and Tafelmeyer, Petra and Zanivan, Sara and Ismail, Shehab and Bryant, David M. and Tomkinson, Nicholas C. O. and Chamberlain, Luke H. and Mastick, Grant S. and Insall, Robert H. and Machesky, Laura M. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20. pp. 1159-1171.

Alamillo-Ferrer, Carla and Curle, Jonathan M and Davidson, Stuart C and Lucas, Simon C C and Atkinson, Stephen J and Campbell, Matthew and Kennedy, Alan R and Tomkinson, Nicholas C O (2018) Alkene oxyamination using malonoyl peroxides : preparation of pyrrolidines and isoxazolidines. Journal of Organic Chemistry, 83 (12). pp. 6728-6740. ISSN 0022-3263

Pariollaud, Marie and Gibbs, Julie E. and Hopwood, Thomas W. and Brown, Sheila and Begley, Nicola and Vonslow, Ryan and Poolman, Toryn and Guo, Baoqiang and Saer, Ben and Jones, D. Heulyn and Tellam, James P. and Bresciani, Stefano and Tomkinson, Nicholas C.O. and Wojno-Picon, Justyna and Cooper, Anthony W.J. and Daniels, Dion A. and Trump, Ryan P. and Grant, Daniel and Zuercher, William and Willson, Timothy M. and MacDonald, Andrew S. and Bolognese, Brian and Podolin, Patricia L. and Sanchez, Yolanda and Loudon, Andrew S.I. and Ray, David W. (2018) Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation. Journal of Clinical Investigation, 128 (6). pp. 2281-2296. ISSN 0021-9738

Jamieson, Lauren E. and Greaves, Jennifer and McLellan, Jayde A. and Munro, Kevin R. and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. and Faulds, Karen and Graham, Duncan (2018) Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 197. pp. 30-36. ISSN 1386-1425

Frei, Przemysslaw and Jones, D. Heulyn and Kay, Steven T. and McLellan, Jayde A. and Johnston, Blair F. and Kennedy, Alan R. and Tomkinson, Nicholas C. O. (2018) Regioselective reaction of heterocyclic N-oxides, an acyl chloride and cyclic thioethers. Journal of Organic Chemistry. ISSN 0022-3263

2017

Clegg, Michael and Tomkinson, Nicholas C. O. and Prinjah, Rab K. and Humphreys, Philip G. (2017) Small molecules and their roles in effective pre-clinical target validation. Future Medicinal Chemistry, 9 (14). pp. 1579-1582. ISSN 1756-8919

Jones, D. Heulyn and Kay, Steven T. and McLellan, Jayde A. and Kennedy, Alan R. and Tomkinson, Nicholas C. O. (2017) A regioselective three component reaction of pyridine N-oxides, acyl chlorides and cyclic ethers. Organic Letters. ISSN 1523-7060

Greaves, Jennifer and Munro, Kevin R. and Davidson, Stuart C. and Riviere, Matthieu and Wojno, Justyna and Smith, Terry K. and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2017) Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Proceedings of the National Academy of Sciences, 114 (8). E1365-E1374. ISSN 1091-6490

Diez Ardanuy, Cinta and Greaves, Jennifer and Munro, Kevin R. and Tomkinson, Nicholas C.O. and Chamberlain, Luke H. (2017) A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Scientific Reports. 10. ISSN 2045-2322

2016

Jones, D. Heulyn and Tellam, James P. and Bresciani, Stefano and Wojno-Picon, Justyna and Cooper, Anthony W. J. and Tomkinson, Nicholas C. O. (2016) Preparation of symmetrical and non-symmetrical fluorene sulfonamide scaffolds. Synlett, 28 (5). pp. 577-582. ISSN 0936-5214

Theodoulou, Natalie H and Tomkinson, Nicholas CO and Prinjha, Rab K and Humphreys, Philip G (2016) Clinical progress and pharmacology of small molecule bromodomain inhibitors. Current Opinion in Chemical Biology, 33. pp. 58-66. ISSN 1367-5931

Dragan, Andrei and Jones, D. Heulyn and Kennedy, Alan R. and Tomkinson, Nicholas C. O. (2016) Stereoselective synthesis of alkylidene phthalides. Organic Letters, 18. pp. 3086-3089. ISSN 1523-7060

Alamillo-Ferrer, Carla and Karabourniotis-Sotti, Marianna and Kennedy, Alan R. and Campbell, Matthew and Tomkinson, Nicholas C. O. (2016) Alkene dioxygenation with malonoyl peroxides : synthesis of ɣ-lactones, isobenzofuranones and tetrahydrofurans. Organic Letters. ISSN 1523-7060

Colleville, Aymeric P. and Horan, Richard A. J. and Olazabal, Sandrine and Tomkinson, Nicholas C. O. (2016) C–H arylation of heterocyclic N oxides through in-situ diazotisation of anilines without added promoters : a green and selective coupling process. Organic Process Research and Development, 20 (7). 1283–1296. ISSN 1083-6160

Tomkinson, Nicholas; (2016) 5,6-Dioxaspiro[2.4]heptane-4,7-dione. In: e-EROS Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons Inc.. ISBN 9780470842898

Theodoulou, Natalie H. and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2016) Progress in the development of non-​BET bromodomain chemical probes. ChemMedChem, 11 (5). pp. 477-487. ISSN 1860-7179

Theodoulou, Natalie H. and Bamborough, Paul and Bannister, Andrew J. and Becher, Isabelle and Bit, Rino A. and Che, Ka Hing and Chung, Chun-wa and Dittmann, Antje and Drewes, Gerard and Drewy, David H. and Gordon, Laurie and Grandi, Paola and Leveridge, Melanie and Lindon, Matthew and Michon, Anne-Marie and Molnar, Judit and Robson, Samuel C. and Tomkinson, Nicholas C. O. and Kouzarides, Tony and Prinjha, Rab K. and Humphreys, Philip G. (2016) The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. Journal of Medicinal Chemistry, 59 (4). pp. 1425-1439. ISSN 0022-2623

Jones, D. Heulyn and Bresciani, Stefano and Tellam, James P. and Wojno, Justyna and Cooper, Anthony W J and Kennedy, Alan R. and Tomkinson, Nicholas C O (2016) Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers. Organic and Biomolecular Chemistry, 14 (1). pp. 172-182. ISSN 1477-0520

2015

Bradley, Tyne D. and Dragan, Andrei and Tomkinson, Nicholas C.O. (2015) Baeyer–Villiger oxidation under Payne epoxidation conditions. Tetrahedron, 71 (42). 8155–8161. ISSN 0040-4020

Alamillo-Ferrer, Carla and Davidson, Stuart C. and Rawling, Michael J. and Theodoulou, Natalie H. and Campbell, Matthew and Humphreys, Philip G. and Kennedy, Alan R. and Tomkinson, Nicholas C. O. (2015) Alkene anti-dihydroxylation with malonoyl peroxides. Organic Letters, 17 (20). pp. 5132-5135. ISSN 1523-7060

Bagley, Mark C. and Dwyer, Jessica E. and Molina, Maria D Beltran and Rand, Alexander W. and Rand, Hayley L. and Tomkinson, Nicholas C. O. (2015) Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors. Organic and Biomolecular Chemistry, 13 (24). pp. 6814-6824. ISSN 1477-0520

Dragan, Andrei and Kubczyk, Tomasz M. and Rowley, Julian H. and Sproules, Stephen and Tomkinson, Nicholas C. O. (2015) Arene oxidation with malonoyl peroxides. Organic Letters, 17 (11). pp. 2618-2621. ISSN 1523-7060

Brazier, John B. and Gibbs, Timothy J. K. and Rowley, Julian H. and Samulis, Leopold and Yau, Sze Chak and Kennedy, Alan R. and Platts, James A. and Tomkinson, Nicholas C. O. (2015) Improving catalyst activity in secondary amine catalysed transformations. Organic and Biomolecular Chemistry, 13 (1). pp. 133-141. ISSN 1477-0520

2014

Bresciani, Stefano and Tomkinson, Nicholas C. O. (2014) Transition metal-mediated synthesis of oxazoles. Heterocycles, 89 (11). pp. 2479-2543. ISSN 0385-5414

Colleville, Aymeric P. and Horan, Richard A. J. and Tomkinson, Nick C. O. (2014) Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction : from optimisation to mole scale. Organic Process Research and Development, 18 (9). 1128–1136. ISSN 1083-6160

Rawling, Michael J. and Rowley, Julian H. and Campbell, Matthew and Kennedy, Alan R. and Parkinson, John A. and Tomkinson, Nicholas C. O. (2014) Mechanistic insights into the malonoyl peroxide syn-dihydroxylation of alkenes. Chemical Science, 5 (5). pp. 1777-1785. ISSN 2041-6539

2013

Trump, Ryan P. and Bresciani, Stefano and Cooper, Anthony W. J. and Tellam, James P. and Wojno, Justyna and Blaikley, John and Orband-Miller, Lisa A. and Kashatus, Jennifer A. and Boudjelal, Mohamed and Dawson, Helen C. and Loudon, Andrew and Ray, David and Grant, Daniel and Farrow, Stuart N. and Willson, Timothy M. and Tomkinson, Nicholas C. O. (2013) Optimized chemical probes for REV-ERB alpha. Journal of Medicinal Chemistry, 56 (11). pp. 4729-4737. ISSN 0022-2623

Rowley, Julian and Yau, Sze Chak and Kariuki, Benson M and Kennedy, Alan and Tomkinson, Nick (2013) Readily accessible chiral at nitrogen cage structures. Organic and Biomolecular Chemistry, 11 (13). pp. 2198-2205. ISSN 1477-0520

Rowley, Julian and Tomkinson, Nick; Christmann, Mathias and Bräse, Stefan, eds. (2013) Organocatalyzed transformations of alpha,beta-unsaturated carbonyl compounds through iminium ion intermediates. In: Asymmetric Synthesis II. John Wiley & Sons Inc., Weinheim, pp. 29-34. ISBN 9783527329212

Knapp, Stefan and Arruda, Paulo and Blagg, Julian and Burley, Stephen and Drewery, David and Edwards, Aled and Fabbro, Doriano and Gillespie, Paul and Gray, Nathanael S and Kuster, Bernhard and Lackey, Karen E and Mazzafera, Paulo and Tomkinson, Nick and Willson, Timothy and Workman, Paul and Zuercher, William (2013) A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology, 9 (1). pp. 3-6. ISSN 1552-4450

Rawling, Michael and Tomkinson, Nick (2013) Metal-free syn-dioxygenation of alkenes. Organic and Biomolecular Chemistry, 11 (9). pp. 1434-1440. ISSN 1477-0520

2012

Picon, Sylvain and Rawling, Michael and Campbell, Matthew and Tomkinson, Nick (2012) Alkene dihydroxylation with malonoyl peroxides : catalysis using fluorinated alcohols. Organic Letters, 14 (24). pp. 6250-6253. ISSN 1523-7060

Tomkinson, Nick and Rowley, Julian; Christmann, Mathias and Brase, Stefan, eds. (2012) Organocatalysed transformations of alpha,beta-unsaturated carbonyl compoundsthrough iminium ion intermediates. In: Asymmetric Synthesis. Wiley-VCH, Weinheim, pp. 29-34. ISBN 9783527329007

Smithen, Deborah and Mathews, Christopher and Tomkinson, Nick (2012) Asymmetric alpha-oxyacylation of cyclic ketones. Organic and Biomolecular Chemistry, 10 (18). pp. 3756-3762. ISSN 1477-0520

Tomkinson, Nick and Jones, Kevin M (2012) Metal-free dihydroxylation of alkenes using cyclobutane malonoyl peroxide. Journal of Organic Chemistry, 77 (2). pp. 921-928. ISSN 0022-3263

2011

Samulis, Leopold and Tomkinson, Nicholas C.O. (2011) Preparation of the MacMillan Imidazolidinones. Tetrahedron, 67 (23). pp. 4263-4267. ISSN 0040-4020

Brazier, John B and Hopkins, Greg P and Jirari, Meriem and Mutter, Shaun and Pommereuil, Ronan and Samulis, Leopold and Platts, James A and Tomkinson, Nicholas C.O. (2011) Iminium ion catalysis: direct comparison of imidazolidinone and diarylprolinol ether reactivity. Tetrahedron Letters, 52 (21). pp. 2783-2785. ISSN 0040-4039

Brazier, John B. and Jones, Kevin M. and Platts, James A. and Tomkinson, Nicholas C.O. (2011) On the roles of protic solvents in imidazolidinone-catalyzed transformations. Angewandte Chemie, 50 (7). pp. 1613-1616. ISSN 1521-3773

2010

Griffith, James C and Jones, Kevin M and Picon, Sylvain and Rawling, Michael J and Kariuki, Benson M and Campbell, Matthew and Tomkinson, Nicholas C. O. (2010) Alkene syn dihydroxylation with malonoyl peroxides. Journal of the American Chemical Society, 132 (41). pp. 14409-14411. ISSN 1520-5126

Porzelle, Achim and Cooper, Anthony W. J. and Woodrow, Michael D and Tomkinson, Nicholas C.O. (2010) 2-aminophenols containing electron-withdrawing groups from N-aryl hydroxylamines. Synlett, 2010 (16). pp. 2471-2473. ISSN 0936-5214

Porzelle, Achim and Woodrow, Michael D and Tomkinson, Nicholas C. O. (2010) Rearrangement strategy for the synthesis of 2-aminoanilines. Organic Letters, 12 (7). pp. 1492-1495. ISSN 1523-7060

Porzelle, Achim and Woodrow, Michael D and Tomkinson, Nicholas (2010) Synthesis of benzoxazolones from nitroarenes or aryl halides. Organic Letters, 12 (4). pp. 812-815. ISSN 1523-7060

2009

Brazier, John B. and Tomkinson, Nicholas C. O.; List, Benjamin, ed. (2009) Secondary and primary amine catalysts for iminium catalysis. In: Asymmetric Organocatalysis. Topics in Current Chemistry . Springer, pp. 281-347. ISBN 9783642028144

Vaismaa, Matti J. P. and Yau, Sze Chak and Tomkinson, Nicholas C. O. (2009) Organocatalytic α-oxybenzoylation of aldehydes. Tetrahedron Letters, 50 (26). pp. 3625-3627. ISSN 0040-4039

Contiero, Fanny and Jones, Kevin M. and Matts, Edward A. and Porzelle, Achim and Tomkinson, Nicholas C. O. (2009) Direct preparation of benzofurans from O-arylhydroxylamines. Synlett (18). pp. 3003-3006. ISSN 0936-5214

Porzelle, Achim and Woodrow, Michael D. and Tomkinson, Nicholas C. O. (2009) Facile procedure for the synthesis of N-aryl-N-hydroxy carbamates. Synlett (5). pp. 798-802. ISSN 0936-5214

Brazier, John B. and Platts, Jamie A. and Tomkinson, Nicholas C. O. (2009) Iminium ion catalysis: tools and observations. In: UNSPECIFIED.

Porzelle, Achim and Tomkinson, Nicholas C. O. (2009) Palladium catalyzed N-arylation of hydroxylamines. In: UNSPECIFIED.

Porzelle, Achim and Woodrow, Michael D. and Tomkinson, Nicholas C. O. (2009) Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides. Organic Letters, 11 (1). pp. 233-236. ISSN 1523-7060

Porzelle, Achim and Tomkinson, Nicholas C. O. (2009) Rearrangement strategies for aryl-heteroatom bond formation. In: UNSPECIFIED.

Brazier, John B. and Evans, Gareth and Gibbs, Timothy J. K. and Coles, Simon J. and Hursthouse, Michael B. and Platts, James A. and Tomkinson, Nicholas C. O. (2009) Solution phase, solid state, and theoretical investigations on the MacMillan imidazolidinone. Organic Letters, 11 (1). pp. 133-136. ISSN 1523-7060

Tomkinson, Nick and Porzelle, Achim and Cavill, Julie L. and Elliott, Richard L. and Evans, Gareth and Gibbs, Timothy J. K. and Jones, Ian L. and Platts, James A (2009) The alpha-effect in cyclic secondary amines: new scaffolds for iminium ion accelerated transformations. Tetrahedron, 65. p. 9961. ISSN 0040-4020

2008

Evans, Gareth and Gibbs, Timothy J. K. and Jenkins, Robert L. and Coles, Simon J. and Hursthouse, Michael B. and Platts, James A. and Tomkinson, Nicholas C. O. (2008) Kinetics of iminium ion catalysis. Agewandte Chemie-International Edition, 47 (15). pp. 2820-2823. ISSN 1521-3773

Jones, Kerri L. and Porzelle, Achim and Hall, Adrian and Woodrow, Michael D. and Tomkinson, Nicholas C. O. (2008) Copper-catalyzed coupling of hydroxylamines with aryl iodides. Organic Letters, 10 (5). pp. 797-800. ISSN 1523-7060

Taylor, Paul H. and Arnott, Euan A. and Tomkinson, Nicholas C. O. (2008) Mechanistic investigations into a novel C-O bond construction process. In: American Chemical Society , USA, 2011-03-31.

Taylor, Paul H. and Arnott, Euan A. and Tomkinson, Nicholas C. O. (2008) Metal-free α-oxygenation of carbonyl compounds: Methodology and mechanism. In: American Chemical Society , USA, 2011-03-31.

Knowles, Deborah A. and Matthews, Christopher J. and Tomkinson, Nicholas C. O. (2008) Novel chiral hydroxylamines for the asymmetric α-functionalisation of carbonyl compounds. In: UNSPECIFIED.

Knowles, Deborah A. and Mathews, Christopher J. and Tomkinson, Nicholas C. O. (2008) Oxidation of primary amines to ketones. Synlett (18). pp. 2769-2772. ISSN 0936-5214

Porzelle, Achim and Woodrow, Michael D. and Tomkinson, Nicholas C. O. (2008) Rearrangement of differentially protected N-arylhydroxylamines. European Journal of Organic Chemistry (30). pp. 5135-5143. ISSN 1434-193X

Knowles, Deborah A. and Matthews, Christopher J. and Tomkinson, Nicholas C. O. (2008) An asymmetric method for the α-oxyacylation of carbonyl compounds. In: American Chemical Society , USA, 2011-03-31.

2007

Gibbs, Timothy J. K. and Platts, Jamie A. and Tomkinson, Nicholas C. O. (2007) Chemical and theoretical tools for understanding iminium ion catalysis. Abstracts of papers - American Chemical Society, 234. ORGN-396. ISSN 0065-7727

Gibbs, Timothy J. K. and Elliott, Richard L. and Evans, Gareth and Jones, Ian L. and Platts, Jamie A. and Tomkinson, Nicholas C. O. (2007) Structure activity relationships of secondary amines in iminium ion catalysis. Abstracts of papers - American Chemical Society, 234. ORGN-631. ISSN 0065-7727

Davies, Huw J. and Ruda, Antionio M. and Tomkinson, Nicholas C. O. (2007) Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect. Tetrahedron Letters, 48 (8). pp. 1461-1464. ISSN 0040-4039

John, Oliver R. S. and Killeen, Niall M. and Knowles, Deborah A. and Yau, Sze Chak and Bagley, Mark C. and Tomkinson, Nicholas C. O. (2007) Direct α-oxytosylation of carbonyl compounds : one-pot synthesis of heterocycles. Organic Letters, 9 (20). pp. 4009-4012. ISSN 1523-7060

Jones, Ian L. and Schofield, Daniel J. and Strevens, Robert R. and Horton, Peter N. and Hursthouse, Michael B. and Tomkinson, Nicholas C. O. (2007) Novel steroid mimics: synthesis of tri- and tetra-substituted oxamides and oxoamides. Tetrahedron Letters, 48 (4). pp. 521-525. ISSN 0040-4039

Hall, Adrian and Huguet, Edouard P. and Jones, Kerri L. and Jones, Teyrnon C. and Killeen, Niall M. and Yau, Sze Chak and Tomkinson, Nicholas C. O. (2007) The direct formation of α-carbamates from carbonyl compounds. Synlett (2). pp. 293-297. ISSN 0936-5214

Gibbs, Timothy J. K. and Boomhoff, Michael and Tomkinson, Nicholas C. O. (2007) A mild and efficient method for the one-pot monocarboxymethylation of primary amines. Synlett (10). pp. 1573-1576. ISSN 0936-5214

Jones, Teyrnon C. and Tomkinson, Nicholas C. O. (2007) A practical procedure for carbonyl α-oxidation: synthesis of (2-benzoyloxy)-1,4-cyclohexanedione mono-ethylene ketal. Organic Syntheses, 84. pp. 233-241. ISSN 0078-6209

2006

Ruda, Antonio M. and Cavill, Julie L. and Tomkinson, Nicholas C. O. (2006) ORGN 140-8-Aryl menthamine-derived scaffolds for iminium ion catalysis. Abstracts of papers - American Chemical Society, 232. 140-ORGN. ISSN 0065-7727

Strevens, Robert and Tomkinson, Nicholas C. O. (2006) Design, synthesis and evaluation of novel steroid mimics. Abstracts of papers - American Chemical Society, 231. MEDI-043. ISSN 0065-7727

Jones, Teyrnon C. and Tomkinson, Nicholas C. O. (2006) New methods in metal-free organic synthesis : a practical procedure for carbonyl α-oxidation. In: 231st ACS National Meeting, 2006-03-26 - 2006-03-30.

Evans, Gareth J. S. and White, Katherine and Platts, James A. and Tomkinson, Nicholas C. O. (2006) Computational study of iminium ion formation: effects of amine structure. Organic and Biomolecular Chemistry, 4 (13). pp. 2616-2627. ISSN 1477-0520

Jones, Teyrnon C. and Killeen, Niall M. and Jones, Kerri L. and Tomkinson, Nicholas C. O. and Hall, Adrian. (2006) New reagents for the metal-free one-pot alpha-functionalisation of carbonyl compounds. Abstracts of papers - American Chemical Society, 231. 365-ORGN. ISSN 0065-7727

Hall, Adrian and Jones, Kerri L. and Jones, Teyrnon C. and Killeen, Niall M. and Porzig, Robert and Taylor, Paul H. and Yau, Sze Chak and Tomkinson, Nicholas C. O. (2006) The direct introduction of carbonates α to carbonyl groups. Synlett (20). pp. 3435-3438. ISSN 0936-5214

Bridgeman, Eve and Tomkinson, Nicholas C. O. (2006) A simple method for the preparation of di-, tri-, and tetrasubstituted non-symmetrical ureas. Synlett (2). pp. 243-246. ISSN 0936-5214

2005

Gibbs, Timothy J. K. and Tomkinson, Nicholas C. O. (2005) Aminocatalytic preparation of bisindolylalkanes. Organic and Biomolecular Chemistry, 3 (22). pp. 4043-4045. ISSN 1477-0520

Bridgeman, Eve and Cavill, Julie L. and Schofield, Daniel J. and Wilkins, Derek S. and Tomkinson, Nicholas C. O. (2005) Novel steroid mimics directed towards the estradiol skeleton. Tetrahedron Letters, 46 (49). pp. 8521-8524. ISSN 0040-4039

Cavill, Julie L. and Elliott, Richard L. and Evans, Gareth and Jones, Ian L. and Platts, James A. and Ruda, Antonio M. and Tomkinson, Nicholas C. O. (2005) The α-effect in iminium ion catalysis. Tetrahedron, 62 (2-3). pp. 410-421. ISSN 0040-4020

Beshara, Cory S. and Hall, Adrian and Jenkins, Robert L. and Jones, Kerri L. and Jones, Teyrnon C. and Killeen, Niall M. and Taylor, Paul H. and Thomas, Stephen P. and Tomkinson, Nicholas C. O. (2005) A general method for the α-acyloxylation of carbonyl compounds. Organic Letters, 7 (25). pp. 5729-5732. ISSN 1523-7060

Harris, Lisa D. and Jenkins, Robert L. and Tomkinson, Nicholas C. O. (2005) The modulation of face-face π-π interactions in Lewis acid catalysis. Tetrahedron Letters, 46 (10). pp. 1627-1629. ISSN 0040-4039

Beshara, Cory S. and Hall, Adrian and Jenkins, Robert L. and Jones, Teyrnon C. and Parry, Rachael T. and Thomas, Stephen P. and Tomkinson, Nicholas C. O. (2005) A simple method for the α-oxygenation of aldehydes. Chemical Communications (11). pp. 1478-1480. ISSN 1359-7345

2004

Bagley, Mark C. and Hughes, David D. and Lubinu, M. Caterina and Merritt, Eleanor A. and Taylor, Paul H. and Tomkinson, Nicholas C. O. (2004) Microwave-assisted synthesis of pyrimidine libraries. QSAR and Combinatorial Science, 23 (10). pp. 859-867. ISSN 1611-020X

2003

Harris, Lisa D. and Platts, James A. and Tomkinson, Nicholas C. O. (2003) Enhanced π···π interactions in α,β-unsaturated carbonyls. Organic and Biomolecular Chemistry, 1 (3). pp. 457-459. ISSN 1477-0520

Cavill, Julie L. and Peters, Jens-Uwe and Tomkinson, Nicholas C. O. (2003) Iminium ion catalysis: Use of the α-effect in the acceleration of the Diels-Alder reaction. Chemical Communications (6). pp. 728-729. ISSN 1359-7345

Coogan, Michael P. and Haigh, Robert and Hall, Adrian and Harris, Lisa D. and Hibbs, David E. and Jenkins, Robert L. and Jones, Claire L. and Tomkinson, Nicholas C. O. (2003) A new chiral diol derived from tetralone for the complexation of Lewis acids. Tetrahedron, 59 (37). pp. 7389-7395. ISSN 0040-4020

Hall, Adrian and Harris, Lisa D. and Jones, Claire L. and Jenkins, Robert L. and Tomkinson, Nicholas C. O. (2003) A simple and versatile method to determine the enantiomeric purity of Diels-Alder adducts. Tetrahedron Letters, 44 (1). pp. 111-114. ISSN 0040-4039

2001

Chappelle, Michael R. and Morgan, Alan D. and Tomkinson, Nicholas C. O. and Willson, Timothy M.; Pleiss, Ulrich and Voges, R., eds. (2001) Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction. In: Synthesis and applications of isotopically labelled compounds, volume 7. Wiley-Blackwell, pp. 80-83. ISBN 0471495018

Tomkinson, Nicholas C. O.; Sainsbury, Malcolm, ed. (2001) Conjugate addition reactions. In: Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds. Elsevier, pp. 199-258. ISBN 9780444533470

Jones, D. N. and Maybury, M. W. J. and Swallow, S. and Tomkinson, N. C. O. and Wood, W. W. (2001) A concise synthesis of homochiral trans-perhydroazulenes and trans-hydrindanes. Tetrahedron Letters, 42 (11). pp. 2193-2195. ISSN 0040-4039

2000

Spencer Thomas A., Jr. and Li, Dansu and Russel, Jonathon S. and Tomkinson, Nicholas C. O. and Willson, Timothy M. (2000) Further studies on synthesis of 24(S),25-epoxycholesterol : new efficient preparation of desmosterol. In: 219th Meeting of the American Chemical Society, 2000-03-26 - 2000-03-30.

Spencer, Thomas A. and Li, Dansu and Russel, Jonathon S. and Tomkinson, Nicholas C. O. and Willson, Timothy M. (2000) Further studies on the synthesis of 24(S),25-epoxycholesterol. A new, efficient preparation of desmosterol. Journal of Organic Chemistry, 65 (7). pp. 1919-1923. ISSN 0022-3263

Jones, Stacey A. and Moore, Linda B. and Shenk, Jennifer L. and Wisely, G. Bruce and Hamilton, Geraldine A. and McKee, David D. and Tomkinson, Nicholas C. O. and LeCluyse, Edward L. and Lambert, Millard H. and Willson, Timothy M. and Kliewer, Steven A. and Moore, John T. (2000) The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Journal of Molecular Endocrinology, 14 (1). pp. 27-39. ISSN 0952-5041

1999

Adams, Harry and Bell, Richard and Cheung, Yiu-Yin and Jones, D. Neville and Tomkinson, Nicholas C. O. (1999) The cleavage of meso-epoxides with homochiral thiols: synthesis of (+)-trans-2-mercaptocyclohexanol and (-)-trans-2-mercaptocyclohexanol. Tetrahedron: Asymmetry, 10 (21). pp. 4129-4142. ISSN 0957-4166

1998

Parks, Derek J. and Tomkinson, Nicholas C. O. and Villeneuve, Manon S. and Blanchard, Steven G. and Willson, Timothy M. (1998) Differential activity of rosiglitazone enantiomers at PPARγ. Bioorganic and Medicinal Chemistry Letters, 8 (24). pp. 3657-3658. ISSN 0960-894X

Tomkinson, Nicholas C. O. and Willson, Timothy M. and Russel, Jonathon S. and Spencer, Thomas A. (1998) Efficient, stereoselective synthesis of 24(S),25-epoxycholesterol. Journal of Organic Chemistry, 63 (26). pp. 9919-9923. ISSN 0022-3263

Messeri, Tommaso and Sternbach, Daniel D. and Tomkinson, Nicholas C. O. (1998) A novel deprotection/functionalization sequence using 2,4-dinitrobenzenesulfonamide. Part 2. Tetrahedron Letters, 39 (13). pp. 1673-1676. ISSN 0040-4039

Messeri, Tommaso and Sternbach, Daniel D. and Tomkinson, Nicholas C. O. (1998) A novel deprotection/functionalization sequence using 2,4-dinitrobenzenesulfonamide: Part 1. Tetrahedron Letters, 39 (13). pp. 1669-1672. ISSN 0040-4039

Adams, Harry and Anderson, James C. and Bell, Richard and Neville Jones, D. and Peel, Michael R. and Tomkinson, Nicholas C. O. (1998) The synthesis and Diels-Alder reactions of (E)- and (Z)-1-methoxy-3-(phenylsulfinyl)-1,3-butadienes. Journal of the Chemical Society, Perkin Transactions 1 (23). pp. 3967-3974. ISSN 1472-7781

1997

Brown, Peter J. and Smith-Oliver, Tracey A. and Charifson, Paul S. and Tomkinson, Nicholas C. O. and Fivush, Adam M. and Sternbach, Daniel D. and Wade, Laura E. and Orband-Miller, Lisa and Parks, Derek J. and Blanchard, Steven G. (1997) Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. Chemistry and Biology, 4 (12). pp. 909-918. ISSN 1074-5521

Tomkinson, Nicholas C. O. and Sefler, Andrea M. and Plunket, Kelli D. and Blanchard, Steven G. and Parks, Derek J. and Willson, Timothy M. (1997) Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands. Bioorganic and Medicinal Chemistry Letters, 7 (19). pp. 2491-2496. ISSN 0960-894X

1993

Jones, D. Neville and Maybury, Mark W. J. and Swallow, Steven and Tomkinson, Nicholas C. O. (1993) Novel cyclizations involving vinyl sulfones: stereoselective construction of perhydroazulenes and trans-hydrindanes. Tetrahedron Letters, 34 (52). pp. 8553-8556. ISSN 0040-4039