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2024

Fyfe, Calum and Barrington, Henry and Gordon, Charles M. and Reid, Marc (2024) A computer vision approach towards verifying CFD models of stirred tank reactors. Organic Process Research and Development, 28 (9). pp. 3661-3673. ISSN 1083-6160

Mehta, Bhavik A. and Gramadnikova, Ekaterina and Brown, Cameron J. and Mitchell, Niall A. and Ottoboni, Sara (2024) Integrated filtration and washing modelling : optimization of impurity rejection for filtration and washing of active pharmaceutical ingredients. Organic Process Research and Development, 28 (4). pp. 1089-1101. ISSN 1083-6160

2023

Eales, William and Price, Chris J. and Hicks, William and Mulheran, Paul A. (2023) Properties of packed bed structures formed during filtration : a two and three-dimensional model. Organic Process Research and Development, 27 (9). pp. 1631-1640. ISSN 1083-6160

Economidou, Marina and Mistry, Nisha and Wheelhouse, Katherine M. P. and Lindsay, David M. (2023) Palladium extraction following metal-catalyzed reactions : recent advances and applications in the pharmaceutical industry. Organic Process Research and Development, 27 (9). pp. 1585-1615. ISSN 1083-6160

2022

Ottoboni, Sara and Brown, Cameron J. and Mehta, Bhavik and Jimeno, Guillermo and Mitchell, Niall A. and Sefcik, Jan and Price, Chris J. (2022) Digital design of filtration and washing of active pharmaceutical ingredients via mechanistic modelling. Organic Process Research and Development, 26 (12). pp. 3236-3253. ISSN 1083-6160

Chong, Magdalene W.S. and McGlone, Thomas and Chai, Ching Yee and Briggs, Naomi E. B. and Brown, Cameron J. and Perciballi, Francesca and Dunn, Jaclyn and Parrott, Andrew J. and Dallin, Paul and Andrews, John and Nordon, Alison and Florence, Alastair J. (2022) Temperature correction of spectra to improve solute concentration monitoring by in situ ultraviolet and mid-infrared spectrometries towards isothermal local model performance. Organic Process Research and Development, 26 (11). pp. 3096-3105. ISSN 1083-6160

Barrington, Henry and Dickinson, Alan and McGuire, Jake and Yan, Chunhui and Reid, Marc (2022) Computer vision for kinetic analysis of lab- and process-scale mixing phenomena. Organic Process Research and Development, 26 (11). pp. 3073-3088. ISSN 1083-6160

Shahid, Muhid and Faure, Chloé and Ottoboni, Sara and Lue, Leo and Price, Chris (2022) Employing constant rate filtration to assess active pharmaceutical ingredient washing efficiency. Organic Process Research and Development, 26 (1). pp. 97-110. ISSN 1083-6160

2021

Yang, Yihui and Ahmed, Bilal and Mitchell, Christopher and Quon, Justin L. and Siddique, Humera and Houson, Ian and Florence, Alastair J. and Papageorgiou, Charles D. (2021) Investigation of wet milling and indirect ultrasound as means for controlling nucleation in the continuous crystallization of an active pharmaceutical ingredient. Organic Process Research and Development, 25 (9). pp. 2119-2132. ISSN 1083-6160

Ottoboni, Sara and Wareham, Bruce and Vassileiou, Antony and Robertson, Murray and Brown, Cameron J. and Johnston, Blair and Price, Chris J. (2021) A novel integrated workflow for isolation solvent selection using prediction and modelling. Organic Process Research and Development, 25 (5). pp. 1143-1159. ISSN 1083-6160

Watson, Oliver L. and Jonuzaj, Suela and McGinty, John and Sefcik, Jan and Galindo, Amparo and Jackson, George and Adjiman, Claire S. (2021) Computer aided design of solvent blends for hybrid cooling and antisolvent crystallization of active pharmaceutical ingredients. Organic Process Research and Development, 25 (5). pp. 1123-1142. ISSN 1083-6160

Shahid, Muhid and Sanxaridou, Georgia and Ottoboni, Sara and Lue, Leo and Price, Chris (2021) Exploring the role of anti-solvent effects during washing on active pharmaceutical ingredient purity. Organic Process Research and Development, 25 (4). pp. 969-981. ISSN 1083-6160

2020

Ottoboni, Sara and Coleman, Simon J. and Steven, Christopher and Siddique, Mariam and Fraissinet, Marine and Joannes, Marion and Laux, Audrey and Barton, Alastair and Firth, Paul and Price, Chris J. and Mulheran, Paul A. (2020) Understanding API static drying with hot gas flow : design and test of a drying rig prototype and drying modelling development. Organic Process Research and Development, 24 (11). pp. 2505-2520. ISSN 1083-6160

Shaalan, Youssef and Boulton, Lee and Jamieson, Craig (2020) Ruthenium-catalyzed ester reductions applied to pharmaceutical intermediates. Organic Process Research and Development, 24 (11). pp. 2745-2751. ISSN 1083-6160

Urwin, Stephanie J. and Levilain, Guillaume and Marziano, Ivan and Merritt, Jeremy M. and Houson, Ian and Ter Horst, Joop H. (2020) A structured approach to cope with impurities during industrial crystallization development. Organic Process Research and Development, 24 (8). pp. 1443-1456. ISSN 1083-6160

Ottoboni, Sara and Shahid, Muhid and Steven, Christopher and Coleman, Simon and Meehan, Elizabeth and Barton, Alastair and Firth, Paul and Sutherland, Richard and Price, Chris J. (2020) Developing a batch isolation procedure and running it in an automated semi-continuous unit : AWL CFD25 case study. Organic Process Research and Development, 24 (4). pp. 520-539. ISSN 1083-6160

2019

Dunn, Andrew S. and Svoboda, Vaclav and Sefcik, Jan and ter Horst, Joop H. (2019) Resolution control in a continuous preferential crystallization process. Organic Process Research and Development, 23 (9). pp. 2031-2041. ISSN 1083-6160

2016

Colleville, Aymeric P. and Horan, Richard A. J. and Olazabal, Sandrine and Tomkinson, Nicholas C. O. (2016) C–H arylation of heterocyclic N oxides through in-situ diazotisation of anilines without added promoters : a green and selective coupling process. Organic Process Research and Development, 20 (7). 1283–1296. ISSN 1083-6160

2015

Chartoire, Anthony and Claver, Carmen and Corpet, Martin and Krinsky, Jamin and Mayen, Julie and Nelson, David and Nolan, Steven P. and Peñafiel, Itziar and Woodward, Robert and Meadows, Rebecca E. (2015) Recyclable NHC catalyst for the development of a generalized approach to continuous Buchwald-Hartwig reaction and work-up. Organic Process Research and Development. ISSN 1083-6160

Briggs, Naomi E. B. and Schacht, Ulrich and Raval, Vishal and McGlone, Thomas and Sefcik, Jan and Florence, Alastair J. (2015) Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer. Organic Process Research and Development, 19 (12). 1903−1911. ISSN 1083-6160

Siddique, Humera and Brown, Cameron J. and Houson, Ian and Florence, Alastair J. (2015) Establishment of a continuous sonocrystallization process for lactose in an oscillatory baffled crystallizer. Organic Process Research and Development, 19 (12). pp. 1871-1881. ISSN 1083-6160

McGlone, Thomas and Briggs, Naomi E. B. and Clark, Catriona A. and Brown, Cameron J. and Sefcik, Jan and Florence, Alastair J. (2015) Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization. Organic Process Research and Development, 19 (9). 1186–1202. ISSN 1083-6160

Reus, Marloes A. and Van Der Heijden, Antoine E. D. M. and Ter Horst, Joop H. (2015) Solubility determination from clear points upon solvent addition. Organic Process Research and Development, 19 (8). pp. 1004-1011. ISSN 1083-6160

2014

Colleville, Aymeric P. and Horan, Richard A. J. and Tomkinson, Nick C. O. (2014) Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction : from optimisation to mole scale. Organic Process Research and Development, 18 (9). 1128–1136. ISSN 1083-6160

Nelson, David J. and Nolan, Steven P. (2014) Letter to the editor concerning : "carbon-heteroatom coupling using pd-peppsi complexes" by Valente et al. Organic Process Research and Development, 18 (4). pp. 456-457. ISSN 1083-6160

2012

Yang, Huaiyu and Rasmuson, Åke C. (2012) Investigation of batch cooling crystallization in a liquid-liquid separating system by PAT. Organic Process Research and Development, 16 (6). pp. 1212-1224. ISSN 1083-6160

2009

Dang, Leping and Yang, Huaiyu and Black, Simon and Wei, Hongyuan (2009) The effect of temperature and solvent composition on transformation of β- to α-glycine as monitored in situ by FBRM and PVM. Organic Process Research and Development, 13 (6). pp. 1301-1306. ISSN 1083-6160