Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction : from optimisation to mole scale

Colleville, Aymeric P. and Horan, Richard A. J. and Tomkinson, Nick C. O. (2014) Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction : from optimisation to mole scale. Organic Process Research and Development, 18 (9). 1128–1136. ISSN 1083-6160

[thumbnail of Colleville-etal-OPRD-2014-Aryldiazonium-tetrafluoroborate-salts-as-green-and-efficient-coupling]
Preview
 Text (Colleville-etal-OPRD-2014-Aryldiazonium-tetrafluoroborate-salts-as-green-and-efficient-coupling)
Colleville_etal_OPRD_2014_Aryldiazonium_tetrafluoroborate_salts_as_green_and_efficient_coupling.pdf
Accepted Author Manuscript
Download (4MB)| Preview

    Abstract

    The use of aryldiazonium tetrafluoroborate salts as coupling partners in the Suzuki-Miyaura reaction was investigated from a process chemistry perspective including safety evaluation, solvent and catalyst screening and multi-variate factor optimization. Optimised conditions were applied to a range of substrates to evaluate the scope and limitations of the reaction and one example was carried out on mole-scale to demonstrate the practicality and scalability of the process

    ORCID iDs

    Colleville, Aymeric P. ORCID logoORCID: https://orcid.org/0000-0003-3094-5155, Horan, Richard A. J. and Tomkinson, Nick C. O. ORCID logoORCID: https://orcid.org/0000-0002-5509-0133;
    • Item type:Article
      ID code:56512
      Dates:
      Date
      Event
      12 August 2014
      Published
      12 August 2014
      Accepted
      Keywords:aryldiazonium tetrafluoroborate salts, Suzuki–Miyaura reaction, mole scale, Chemistry, Organic Chemistry, Physical and Theoretical Chemistry
      Subjects:Science > Chemistry
      Department:Faculty of Science > Pure and Applied Chemistry
      Depositing user: Pure Administrator
      Date deposited:25 May 2016 11:01
      Last modified:23 Sep 2021 04:43
      Related URLs:
      URI:https://strathprints.strath.ac.uk/id/eprint/56512
    CORE (COnnecting REpositories)