Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction : from optimisation to mole scale

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Colleville, Aymeric P. and Horan, Richard A. J. and Tomkinson, Nick C. O. (2014) Aryldiazonium tetrafluoroborate salts as green and efficient coupling partners for the Suzuki-Miyaura reaction : from optimisation to mole scale. Organic Process Research and Development, 18 (9). 1128–1136. ISSN 1083-6160 (https://doi.org/10.1021/op5002353)

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Abstract

The use of aryldiazonium tetrafluoroborate salts as coupling partners in the Suzuki-Miyaura reaction was investigated from a process chemistry perspective including safety evaluation, solvent and catalyst screening and multi-variate factor optimization. Optimised conditions were applied to a range of substrates to evaluate the scope and limitations of the reaction and one example was carried out on mole-scale to demonstrate the practicality and scalability of the process

ORCID iDs

Colleville, Aymeric P. ORCID logoORCID: https://orcid.org/0000-0003-3094-5155, Horan, Richard A. J. and Tomkinson, Nick C. O. ORCID logoORCID: https://orcid.org/0000-0002-5509-0133;
CORE (COnnecting REpositories)