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2021

Shahid, Muhid and Faure, Chloé and Ottoboni, Sara and Lue, Leo and Price, Chris (2021) Employing constant rate filtration to assess active pharmaceutical ingredient washing efficiency. Organic Process Research and Development. ISSN 1083-6160

Ottoboni, Sara and Wareham, Bruce and Vassileiou, Antony and Robertson, Murray and Brown, Cameron J. and Johnston, Blair and Price, Chris J. (2021) A novel integrated workflow for isolation solvent selection using prediction and modelling. Organic Process Research and Development, 25 (5). pp. 1143-1159. ISSN 1083-6160

Shahid, Muhid and Sanxaridou, Georgia and Ottoboni, Sara and Lue, Leo and Price, Chris (2021) Exploring the role of anti-solvent effects during washing on active pharmaceutical ingredient purity. Organic Process Research and Development, 25 (4). pp. 969-981. ISSN 1083-6160

Ottoboni, Sara and Shahid, Muhid and Martin, Alan and Kathyola, Thokozile and Das, Gunjan and Schroeder, Sven and Marathe, Shashidhara and Rau, Christopher and Wanelik, Kaz and Price, Chris John (2021) Fluid and impurity transport during online isolation experiments conducted with X-ray tomography. In: 13th World Filtration Congress, 2021-09-20 - 2021-09-24. (In Press)

2020

Ottoboni, Sara and Coleman, Simon J. and Steven, Christopher and Siddique, Mariam and Fraissinet, Marine and Joannes, Marion and Laux, Audrey and Barton, Alastair and Firth, Paul and Price, Chris J. and Mulheran, Paul A. (2020) Understanding API static drying with hot gas flow : design and test of a drying rig prototype and drying modelling development. Organic Process Research and Development, 24 (11). pp. 2505-2520. ISSN 1083-6160

Ottoboni, Sara and Shahid, Muhid and Steven, Christopher and Coleman, Simon and Meehan, Elizabeth and Barton, Alastair and Firth, Paul and Sutherland, Richard and Price, Chris J. (2020) Developing a batch isolation procedure and running it in an automated semi-continuous unit : AWL CFD25 case study. Organic Process Research and Development, 24 (4). pp. 520-539. ISSN 1083-6160

Ottoboni, S. and Šimurda, M. and Wilson, S. and Irvine, A. and Ramsay, F. and Price, C.J. (2020) Understanding effect of filtration and washing on dried product : paracetamol case study. Powder Technology, 366. pp. 305-323. ISSN 0032-5910

Price, Chris John and Barton, Alastair and Coleman, Simon; Yazdanpanah, Nima and Nagy, Zoltan, eds. (2020) Continuous isolation of active pharmaceutical ingredients. In: The Handbook of Continuous Crystallization. Royal Society of Chemistry, [S.I.]. ISBN 978-1-83916-131-5

McGinty, John and Yazdanpanah, Nima and Price, Chris John and Ter Horst, Joop and Sefcik, Jan; Yazdanpanah, Nima and Nagy, Zoltan, eds. (2020) Nucleation and crystal growth in continuous crystallization. In: The Handbook of Continuous Crystallization. Royal Society of Chemistry, [S.I.], pp. 1-50. ISBN 978-1-83916-131-5

2019

Forbes, Clarissa and Price, Chris and O'Leary, Richard; (2019) Quantifying ultrasound for sono-crystallization. In: 2019 IEEE International Ultrasonics Symposium (IUS). IEEE International Ultrasonics Symposium (IUS) . IEEE, GBR. ISBN 978-1-7281-4596-9

Ojo, E. and Rayat, ACME. and Brown, C. and Price, C. and Hoare, M. and Florence, A. and Johnston, Andrea (2019) Quality by design approach for early understanding of active pharmaceutical ingredient recovery process through dead-end filtration. In: The American Association of Pharmaceutical Scientists (AAPS) 2019 PharmaSci 360, 2019-11-03 - 2019-11-06, Henry B. Gonzalez Convention Center.

Ojo, E.O. and Rayat, A. and Price, C.J. and Brown, C.J. and Hoare, M. and Johnston, A. and Florence, A.J. (2019) Unconventional ultra scale-down techniques for active pharmaceutical ingredient filtration and size reduction. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

Nguyen, Thai Thu Hien and Vesga, Jazmin and Parkinson, John and Price, Chris John (2019) Developing a method to determine the flux of material arriving and leaving a crystal at equilibrium. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

Shahid, Muhid and Sanxaridou, Georgia and Ottoboni, Sara and Lue, Leo and Price, Chris (2019) Understanding and mitigating the consequences of undesired crystallisation taking place during washing of active pharmaceuticals. In: British Association of Crystal Growth 50th Annual Conference, 2019-07-09 - 2019-07-11, Sussex Place.

Ottoboni, Sara and Price, Chris J. and Steven, Christopher and Meehan, Elizabeth and Barton, Alastair and Firth, Paul and Mitchell, Andy and Tahir, Furqan (2019) Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing. Journal of Pharmaceutical Sciences, 108 (1). pp. 372-381. ISSN 0022-3549

2018

Brown, Cameron J. and McGlone, Thomas and Yerdelen, Stephanie and Srirambhatla, Vijay and Mabbott, Fraser and Gurung, Rajesh and Briuglia, Maria L. and Ahmed, Bilal and Polyzois, Hector and McGinty, John and Perciballi, Francesca and Fysikopoulos, Dimitris and Macfhionnghaile, Pól and Siddique, Humera and Raval, Vishal and Harrington, Tomás S. and Vassileiou, Antony D. and Robertson, Murray and Prasad, Elke and Johnston, Andrea and Johnston, Blair and Nordon, Alison and Srai, Jagjit S. and Halbert, Gavin and ter Horst, Joop H. and Price, Chris J. and Rielly, Chris D. and Sefcik, Jan and Florence, Alastair J. (2018) Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisations. Molecular Systems Design & Engineering, 2018 (3). pp. 518-549. ISSN 2058-9689

Forbes, Clarissa and Nguyen, Thai T. H. and O'Leary, Richard L. and Price, Chris J. (2018) Elucidating the mechanism of paracetamol sonocrystallization for product purity enhancement. Proceedings of Meetings on Acoustics, 32. ICU2017 - 287. ISSN 1939-800X

Ottoboni, Sara and Chrubasik, Michael and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Robertson, Murray and Johnston, Blair and Oswald, Iain D. H. and Florence, Alastair and Price, Chris (2018) Impact of paracetamol impurities on face properties : investigating the surface of single crystals using TOF-SIMS. Crystal Growth and Design, 18 (5). 2750–2758. ISSN 1528-7483

2017

Nguyen, Thai T. H. and Khan, Azeem and Bruce, Layla M. and Forbes, Clarissa and O'Leary, Richard L. and Price, Chris J. (2017) The effect of ultrasound on the crystallisation of paracetamol in the presence of structurally similar impurities. Crystals, 7 (10). 294. ISSN 2073-4352

Price, Christopher J.; Roberts, Kevin J. and Docherty, Robert and Tamura, Rui, eds. (2017) Continuous pharmaceutical crystallization from solution. In: Engineering Crystallography. Springer, ITA, pp. 315-329. ISBN 9789402411171

Ojo, Ebenezer and Rayat, Andrea and Johnston, Andrea and Price, Chris John and Price, Chris and Florence, Alastair and Hoare, Mike (2017) Process development for recovery of crystals using DoE. In: British Association of Crystal Growth 50th Annual Conference, 2019-07-09 - 2019-07-11, Sussex Place.

Price, Chris John and Ottoboni, Sara (2017) Addressing the challenges of continuous filtration, washing and drying. In: Continuous manufacturing 2017, 2017-02-22 - 2017-02-23, Druids Glen Hotel.

2016

Ottoboni, S. and Price, C. J. and Steven, C. and Meehan, E. and Barton, A. and Mitchell, A. (2016) Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing : a case study using paracetamol. In: Filtech, 2016-10-11 - 2016-10-13, Koelnmesse.

Ottoboni, Sara and Chrubasik, Michael and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Johnston, Blair and Florence, Alastair and Price, Chris John (2016) The impact of paracetamol impurities on face-specific properties : investigating the surface of single crystals using TOF-SIMS. In: Crystal Growth of Organic Materials, 2016-06-26 - 2016-06-30, University of Leeds.

Price, Chris John and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Hadil, Hailani (2016) The impact of solvent systems, process conditions and structurally related impurities on the growth rate and morphologies of paracetamol crystals. In: Crystal Growth of Organic Materials, 2016-06-26 - 2016-06-30, University of Leeds.

2015

Rossi, Damiano and Gavriilidis, Asterios and Kuhn, Simon and Candel, Miguel Ardid and Jones, Alan G. and Price, Chris and Mazzei, Luca (2015) Adipic acid primary nucleation kinetics from probability distributions in droplet-based systems under stagnant and flow conditions. Crystal Growth and Design, 15 (4). pp. 1784-1791. ISSN 1528-7483