Browse by Author or creator

2024

Brown, Cameron J. and McGinty, John and Islam, Muhammad T. and Rajoub, Nazer and Arjmandi-Tash, Omid and Ottoboni, Sara and Shahid, Muhid and Urwin, Stephanie J. and Lee, Ye Seol and Chong, Magdalene W. S. and Papathanasiou, Foteini and Prakash, Aruna S. and Prasad, Elke and Spence, Bronwyn and Sefcik, Jan and Robertson, John and Smith, Rachel and Litster, James D. and Price, Chris J. and Nordon, Alison and Adjiman, Claire S. and Florence, Alastair J. (2024) Integrated continuous process design for crystallisation, spherical agglomeration, and filtration of lovastatin. Journal of Pharmaceutical Innovation, 19 (2). 9. ISSN 1939-8042

2023

Eales, William and Price, Chris J. and Hicks, William and Mulheran, Paul A. (2023) Properties of packed bed structures formed during filtration : a two and three-dimensional model. Organic Process Research and Development, 27 (9). pp. 1631-1640. ISSN 1083-6160

Urwin, Stephanie J. and Chong, Magdalene W.S. and Li, Wei and McGinty, John and Mehta, Bhavik and Ottoboni, Sara and Pathan, Momina and Prasad, Elke and Robertson, Murray and McGowan, Mark and al-Attili, Mais and Gramadnikova, Ekaterina and Siddique, Mariam and Houson, Ian and Feilden, Helen and Benyahia, Brahim and Brown, Cameron J. and Halbert, Gavin W. and Johnston, Blair and Nordon, Alison and Price, Chris J. and Reilly, Chris D. and Sefcik, Jan and Florence, Alastair J. (2023) Digital process design to define and deliver pharmaceutical particle attributes. Chemical Engineering Research and Design, 196. pp. 726-749. ISSN 0263-8762

Al-Attili, Mais and Ferreira, Carla and Price, Chris and Faulds, Karen and Chen, Yi-Chieh (2023) Development of a spatially offset Raman spectroscopy probe for monitoring pharmaceutical drying. Chemical Engineering Research and Design, 192. pp. 510-520. ISSN 0263-8762

McGinty, John and Wheatcroft, Helen and Price, Chris J. and Sefcik, Jan (2023) Modelling solution speciation to predict pH and supersaturation for design of batch and continuous organic salt crystallisation processes. Fluid Phase Equilibria, 565. 113676. ISSN 0378-3812

2022

Chong, Magdalene W. S. and Ottoboni, Sara and Martin, Alan R. G. and Bowering, Deborah and Price, Chris J. and Nordon, Alison and Oswald, Iain D. H. and Ward, Martin R. (2022) Crystal structure of a copper-mefenamate complex solvated with diglyme and water. Acta Crystallographica Section E: Structure Reports, 78 (Part 1). ISSN 1600-5368

Ottoboni, Sara and Brown, Cameron J. and Mehta, Bhavik and Jimeno, Guillermo and Mitchell, Niall A. and Sefcik, Jan and Price, Chris J. (2022) Digital design of filtration and washing of active pharmaceutical ingredients via mechanistic modelling. Organic Process Research and Development, 26 (12). pp. 3236-3253. ISSN 1083-6160

Valitov, Gleb and Rossi, Damiano and Price, Chris and Gavriilidis, Asterios and Mazzei, Luca (2022) Axial dispersion in curved channels in the presence of pulsating flow. Chemical Engineering and Processing - Process Intensification, 180. 108629. ISSN 0255-2701

Shahid, Muhid and Sanxaridou, Georgia and Ottoboni, Sara and Lue, Leo and Price, Chris (2022) Exploring the role of anti-solvent effects during washing on active pharmaceutical product purity. In: 13th World Filtration Congress, 2022-10-05 - 2022-10-09.

Ottoboni, Sara and Shahid, Muhid and Martin, Alan and Kathyola, Thokozile and Das, Gunjan and Schroeder, Sven and Marathe, Shashidhara and Rau, Christopher and Wanelik, Kaz and Price, Chris John (2022) Fluid and impurity transport during online isolation experiments conducted with X-ray tomography. In: 13th World Filtration Congress, 2022-10-05 - 2022-10-09.

Siddique, Mariam and Laux, Audrey and Ottoboni, Sara and Price, Chris and Mulheran, Paul (2022) Transport of impurities and residual solvent during static drying. In: 13th World Filtration Congress, 2022-10-05 - 2022-10-09.

McGinty, John and Svoboda, Vaclav and Macfhionnghaile, Pol and Wheatcroft, Helen and Price, Chris J. and Sefcik, Jan (2022) Continuous crystallisation of organic salt polymorphs. Frontiers in Chemical Engineering, 4. 896329. ISSN 2673-2718

Chong, Magdalene and Brown, Cameron and Mustoe, Chantal and McGinty, John and Li, Wei and Pathan, Momina and Ottoboni, Sara and Prasad, Elke and Robertson, Murray and Mehta, Bhavik and McGowan, Mark and Siddique, Humera and Raval, Vishal and Pereira Diaz, Laura and Siddique, Mariam and Eales, William and Turner, Alice and Johnston, Blair and Robertson, John and Halbert, Gavin and Price, Chris and Benyahia, Brahim and Rielly, Chris and Sefcik, Jan and Nordon, Alison and McGlone, Thomas and Smith, Kenneth and Feilden, Helen and Houson, Ian and Florence, Alastair (2022) The CMAC MicroFactory : mefenamic acid. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Pathan, Momina and McGinty, John and Chong, Magdalene W. S. and Robertson, Murray and Ottoboni, Sara and Li, Wei and McGowan, Mark and Ojo, Ebenezer and Anwar, Ali and Brown, Cameron J. and Sefcik, Jan and Nordon, Alison and Johnston, Blair and Price, Chris J. and Rielly, Chris D. and Benyahia, Brahim and Houson, Ian and Florence, Alastair J (2022) Crystallisation MicroFactory test bed. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Eales, William L. and Price, Chris J. and Mulheran, Paul A. (2022) Modelling packed bed structures. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Siddique, Mariam and Laux, Audrey and Ottoboni, Sara and Price, Chris and Mulheran, Paul (2022) Understanding drying effects on active pharmaceutical ingredient particle properties. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Shahid, Muhid and Faure, Chloé and Ottoboni, Sara and Lue, Leo and Price, Chris (2022) Employing constant rate filtration to assess active pharmaceutical ingredient washing efficiency. Organic Process Research and Development, 26 (1). pp. 97-110. ISSN 1083-6160

2021

Ottoboni, Sara and Wareham, Bruce and Vassileiou, Antony and Robertson, Murray and Brown, Cameron J. and Johnston, Blair and Price, Chris J. (2021) A novel integrated workflow for isolation solvent selection using prediction and modelling. Organic Process Research and Development, 25 (5). pp. 1143-1159. ISSN 1083-6160

Shahid, Muhid and Sanxaridou, Georgia and Ottoboni, Sara and Lue, Leo and Price, Chris (2021) Exploring the role of anti-solvent effects during washing on active pharmaceutical ingredient purity. Organic Process Research and Development, 25 (4). pp. 969-981. ISSN 1083-6160

2020

Ottoboni, Sara and Coleman, Simon J. and Steven, Christopher and Siddique, Mariam and Fraissinet, Marine and Joannes, Marion and Laux, Audrey and Barton, Alastair and Firth, Paul and Price, Chris J. and Mulheran, Paul A. (2020) Understanding API static drying with hot gas flow : design and test of a drying rig prototype and drying modelling development. Organic Process Research and Development, 24 (11). pp. 2505-2520. ISSN 1083-6160

Ottoboni, Sara and Shahid, Muhid and Steven, Christopher and Coleman, Simon and Meehan, Elizabeth and Barton, Alastair and Firth, Paul and Sutherland, Richard and Price, Chris J. (2020) Developing a batch isolation procedure and running it in an automated semi-continuous unit : AWL CFD25 case study. Organic Process Research and Development, 24 (4). pp. 520-539. ISSN 1083-6160

Ottoboni, S. and Šimurda, M. and Wilson, S. and Irvine, A. and Ramsay, F. and Price, C.J. (2020) Understanding effect of filtration and washing on dried product : paracetamol case study. Powder Technology, 366. pp. 305-323. ISSN 0032-5910

Price, Chris John and Barton, Alastair and Coleman, Simon; Yazdanpanah, Nima and Nagy, Zoltan, eds. (2020) Continuous isolation of active pharmaceutical ingredients. In: The Handbook of Continuous Crystallization. Royal Society of Chemistry, [S.I.]. ISBN 978-1-83916-131-5

McGinty, John and Yazdanpanah, Nima and Price, Chris John and Ter Horst, Joop and Sefcik, Jan; Yazdanpanah, Nima and Nagy, Zoltan, eds. (2020) Nucleation and crystal growth in continuous crystallization. In: The Handbook of Continuous Crystallization. Royal Society of Chemistry, [S.I.], pp. 1-50. ISBN 978-1-83916-131-5

2019

Forbes, Clarissa and Price, Chris and O'Leary, Richard; (2019) Quantifying ultrasound for sono-crystallization. In: 2019 IEEE International Ultrasonics Symposium (IUS). IEEE International Ultrasonics Symposium (IUS) . IEEE, GBR. ISBN 978-1-7281-4596-9

Ojo, E. and Rayat, ACME. and Brown, C. and Price, C. and Hoare, M. and Florence, A. and Johnston, Andrea (2019) Quality by design approach for early understanding of active pharmaceutical ingredient recovery process through dead-end filtration. In: The American Association of Pharmaceutical Scientists (AAPS) 2019 PharmaSci 360, 2019-11-03 - 2019-11-06, Henry B. Gonzalez Convention Center.

Ojo, E.O. and Rayat, A. and Price, C.J. and Brown, C.J. and Hoare, M. and Johnston, A. and Florence, A.J. (2019) Unconventional ultra scale-down techniques for active pharmaceutical ingredient filtration and size reduction. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

Nguyen, Thai Thu Hien and Vesga, Jazmin and Parkinson, John and Price, Chris John (2019) Developing a method to determine the flux of material arriving and leaving a crystal at equilibrium. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

Shahid, Muhid and Sanxaridou, Georgia and Ottoboni, Sara and Lue, Leo and Price, Chris (2019) Understanding and mitigating the consequences of undesired crystallisation taking place during washing of active pharmaceuticals. In: British Association of Crystal Growth 50th Annual Conference, 2019-07-09 - 2019-07-11, Sussex Place.

Ottoboni, Sara and Price, Chris J. and Steven, Christopher and Meehan, Elizabeth and Barton, Alastair and Firth, Paul and Mitchell, Andy and Tahir, Furqan (2019) Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing. Journal of Pharmaceutical Sciences, 108 (1). pp. 372-381. ISSN 0022-3549

2018

Brown, Cameron J. and McGlone, Thomas and Yerdelen, Stephanie and Srirambhatla, Vijay and Mabbott, Fraser and Gurung, Rajesh and Briuglia, Maria L. and Ahmed, Bilal and Polyzois, Hector and McGinty, John and Perciballi, Francesca and Fysikopoulos, Dimitris and Macfhionnghaile, Pól and Siddique, Humera and Raval, Vishal and Harrington, Tomás S. and Vassileiou, Antony D. and Robertson, Murray and Prasad, Elke and Johnston, Andrea and Johnston, Blair and Nordon, Alison and Srai, Jagjit S. and Halbert, Gavin and ter Horst, Joop H. and Price, Chris J. and Rielly, Chris D. and Sefcik, Jan and Florence, Alastair J. (2018) Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisations. Molecular Systems Design & Engineering, 2018 (3). pp. 518-549. ISSN 2058-9689

Forbes, Clarissa and Nguyen, Thai T. H. and O'Leary, Richard L. and Price, Chris J. (2018) Elucidating the mechanism of paracetamol sonocrystallization for product purity enhancement. Proceedings of Meetings on Acoustics, 32. ICU2017 - 287. ISSN 1939-800X

Ottoboni, Sara and Chrubasik, Michael and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Robertson, Murray and Johnston, Blair and Oswald, Iain D. H. and Florence, Alastair and Price, Chris (2018) Impact of paracetamol impurities on face properties : investigating the surface of single crystals using TOF-SIMS. Crystal Growth and Design, 18 (5). 2750–2758. ISSN 1528-7483

2017

Nguyen, Thai T. H. and Khan, Azeem and Bruce, Layla M. and Forbes, Clarissa and O'Leary, Richard L. and Price, Chris J. (2017) The effect of ultrasound on the crystallisation of paracetamol in the presence of structurally similar impurities. Crystals, 7 (10). 294. ISSN 2073-4352

Price, Christopher J.; Roberts, Kevin J. and Docherty, Robert and Tamura, Rui, eds. (2017) Continuous pharmaceutical crystallization from solution. In: Engineering Crystallography. Springer, ITA, pp. 315-329. ISBN 9789402411171

Ojo, Ebenezer and Rayat, Andrea and Johnston, Andrea and Price, Chris John and Price, Chris and Florence, Alastair and Hoare, Mike (2017) Process development for recovery of crystals using DoE. In: British Association of Crystal Growth 50th Annual Conference, 2019-07-09 - 2019-07-11, Sussex Place.

Price, Chris John and Ottoboni, Sara (2017) Addressing the challenges of continuous filtration, washing and drying. In: Continuous manufacturing 2017, 2017-02-22 - 2017-02-23, Druids Glen Hotel.

2016

Ottoboni, S. and Price, C. J. and Steven, C. and Meehan, E. and Barton, A. and Mitchell, A. (2016) Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing : a case study using paracetamol. In: Filtech, 2016-10-11 - 2016-10-13, Koelnmesse.

Ottoboni, Sara and Chrubasik, Michael and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Johnston, Blair and Florence, Alastair and Price, Chris John (2016) The impact of paracetamol impurities on face-specific properties : investigating the surface of single crystals using TOF-SIMS. In: Crystal Growth of Organic Materials, 2016-06-26 - 2016-06-30, University of Leeds.

Price, Chris John and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Hadil, Hailani (2016) The impact of solvent systems, process conditions and structurally related impurities on the growth rate and morphologies of paracetamol crystals. In: Crystal Growth of Organic Materials, 2016-06-26 - 2016-06-30, University of Leeds.

2015

Rossi, Damiano and Gavriilidis, Asterios and Kuhn, Simon and Candel, Miguel Ardid and Jones, Alan G. and Price, Chris and Mazzei, Luca (2015) Adipic acid primary nucleation kinetics from probability distributions in droplet-based systems under stagnant and flow conditions. Crystal Growth and Design, 15 (4). pp. 1784-1791. ISSN 1528-7483