Understanding drying effects on active pharmaceutical ingredient particle properties

Siddique, Mariam and Laux, Audrey and Ottoboni, Sara and Price, Chris and Mulheran, Paul (2022) Understanding drying effects on active pharmaceutical ingredient particle properties. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

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Abstract

The anticipated impact of the research will be to deliver strategies to mitigate undesired granule formation (lumping) and particle breakage which routinely occur during drying and to develop these into a workflow. The main objective of this work is to quantify the amount of deposited material which can cause lump formation. This has been addressed using glass spheres of different sizes and paracetamol (PCM) solutions of different concentrations.

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