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2024

Salehian, Mohammad and Moores, Jonathan and Goldie, Jonathan and Ibrahim, Isra and Mendez Torrecillas, Carlota and Wale, Ishwari and Abbas, Faisal and Maclean, Natalie and Robertson, John and Florence, Alastair and Markl, Daniel (2024) A hybrid system of mixture models for the prediction of particle size and shape, density, and flowability of pharmaceutical powder blends. International Journal of Pharmaceutics: X, 8. 100298. ISSN 2590-1567

Turner, T. D. and O'Shaughnessy, C. and He, X. and Levenstein, M. A. and Hunter, L. and Wojciechowski, J. and Bristowe, H. and Stone, R. and Wilson, C. C. and Florence, A. and Robertson, K. and Kapur, N. and Meldrum, F. C. (2024) Flow‐Xl : a new facility for the analysis of crystallization in flow systems. Journal of Applied Crystallography, 57 (5). pp. 1299-1310. ISSN 0021-8898

Pickles, Thomas and Svoboda, Vaclav and Marziano, Ivan and Brown, Cameron J. and Florence, Alastair J. (2024) Integration of a model-driven workflow into an industrial pharmaceutical facility : supporting process development of API crystallisation. CrystEngComm, 26 (34). pp. 4678-4689. ISSN 1466-8033

Brown, Cameron J. and McGinty, John and Islam, Muhammad T. and Rajoub, Nazer and Arjmandi-Tash, Omid and Ottoboni, Sara and Shahid, Muhid and Urwin, Stephanie J. and Lee, Ye Seol and Chong, Magdalene W. S. and Papathanasiou, Foteini and Prakash, Aruna S. and Prasad, Elke and Spence, Bronwyn and Sefcik, Jan and Robertson, John and Smith, Rachel and Litster, James D. and Price, Chris J. and Nordon, Alison and Adjiman, Claire S. and Florence, Alastair J. (2024) Integrated continuous process design for crystallisation, spherical agglomeration, and filtration of lovastatin. Journal of Pharmaceutical Innovation, 19 (2). 9. ISSN 1939-8042

Pickles, Thomas and Mustoe, Chantal and Brown, Cameron J. and Florence, Alastair J. (2024) Comparative study on adaptive Bayesian optimization for batch cooling crystallization for slow and fast kinetic regimes. Crystal Growth and Design, 24 (3). pp. 1245-1253. ISSN 1528-7483

Pickles, Thomas and Mustoe, Chantal and Boyle, Christopher and Cardona, Javier and Brown, Cameron J. and Florence, Alastair J. (2024) Developing a model-driven workflow for the digital design of small-scale batch cooling crystallisation with the antiviral lamivudine. CrystEngComm, 26 (6). pp. 822-834. ISSN 1466-8033

2023

Tang, Weiwei and Yang, Taimin and Morales-Rivera, Cristian A. and Geng, Xi and Srirambhatla, Vijay K. and Kang, Xiang and Chauhan, Vraj P. and Hong, Sungil and Tu, Qing and Florence, Alastair J. and Mo, Huaping and Calderon, Hector A. and Kisielowski, Christian and Hernandez, Francisco C. Robles and Zou, Xiaodong and Mpourmpakis, Giannis and Rimer, Jeffrey D. (2023) Tautomerism unveils a self-inhibition mechanism of crystallization. Nature Communications, 14 (1). 561. ISSN 2041-1723

Prasad, Elke and Robertson, John and Florence, Alastair J. and Halbert, Gavin W. (2023) Expanding the pharmaceutical formulation space in material extrusion 3D printing applications. Additive Manufacturing, 77. 103803. ISSN 2214-8604

Urwin, Stephanie J. and Chong, Magdalene W.S. and Li, Wei and McGinty, John and Mehta, Bhavik and Ottoboni, Sara and Pathan, Momina and Prasad, Elke and Robertson, Murray and McGowan, Mark and al-Attili, Mais and Gramadnikova, Ekaterina and Siddique, Mariam and Houson, Ian and Feilden, Helen and Benyahia, Brahim and Brown, Cameron J. and Halbert, Gavin W. and Johnston, Blair and Nordon, Alison and Price, Chris J. and Reilly, Chris D. and Sefcik, Jan and Florence, Alastair J. (2023) Digital process design to define and deliver pharmaceutical particle attributes. Chemical Engineering Research and Design, 196. pp. 726-749. ISSN 0263-8762

Smith, Aaron and Bordos, Ecaterina and Robertson, John and Florence, Alastair (2023) The application of SIFT-MS for examining the degradation of polymers. In: CMAC Summer School, 2023-06-14 - 2023-06-16.

Pereira Diaz, Laura and Brown, Cameron J. and Ojo, Ebenezer and Mustoe, Chantal and Florence, Alastair J. (2023) Machine learning approaches to the prediction of powder flow behaviour of pharmaceutical materials from physical properties. Digital Discovery, 2 (3). pp. 692-701. ISSN 2635-098X

Wilkinson, Matthew R. and Pereira Diaz, Laura and Vassileiou, Antony D. and Armstrong, John A. and Brown, Cameron J. and Castro-Dominguez, Bernardo and Florence, Alastair J. (2023) Predicting pharmaceutical powder flow from microscopy images using deep learning. Digital Discovery, 2 (2). pp. 459-470. ISSN 2635-098X

Vassileiou, Antony D. and Robertson, Murray N. and Wareham, Bruce G. and Soundaranathan, Mithushan and Ottoboni, Sara and Florence, Alastair J. and Hartwig, Thoralf and Johnston, Blair F. (2023) A unified ML framework for solubility prediction across organic solvents. Digital Discovery, 2 (2). pp. 356-367. ISSN 2635-098X

Yerdelen, Stephanie and Yang, Yihui and Quon, Justin L. and Papageorgiou, Charles D. and Mitchell, Chris and Houson, Ian and Sefcik, Jan and ter Horst, Joop H. and Florence, Alastair J and Brown, Cameron J. (2023) Machine learning derived correlations for scale-up and technology transfer of primary nucleation kinetics. Crystal Growth and Design, 23 (2). pp. 681-693. ISSN 1528-7483

2022

Deng, Tong and Garg, Vivek and Pereira Diaz, Laura and Markl, Daniel and Brown, Cameron and Florence, Alastair and Bradley, Michael S.A. (2022) Comparative studies of powder flow predictions using milligrams of powder for identifying powder flow issues. International Journal of Pharmaceutics, 628. 122309. ISSN 1873-3476

Paladino, Eleonora and Doerr, Frederik J.S. and Bordos, Ecaterina and Onyemelukwe, Iyke I. and Lamprou, Dimitrios A. and Florence, Alastair J. and Gilmore, Ian S. and Halbert, Gavin W. (2022) High spatial resolution ToF-SIMS imaging and image analysis strategies to monitor and quantify early phase separation in amorphous solid dispersions. International Journal of Pharmaceutics, 628. 122191. ISSN 1873-3476

Chong, Magdalene W.S. and McGlone, Thomas and Chai, Ching Yee and Briggs, Naomi E. B. and Brown, Cameron J. and Perciballi, Francesca and Dunn, Jaclyn and Parrott, Andrew J. and Dallin, Paul and Andrews, John and Nordon, Alison and Florence, Alastair J. (2022) Temperature correction of spectra to improve solute concentration monitoring by in situ ultraviolet and mid-infrared spectrometries towards isothermal local model performance. Organic Process Research and Development, 26 (11). pp. 3096-3105. ISSN 1083-6160

Pickles, Thomas and Mustoe, Chantal and Brown, Cameron and Florence, Alastair (2022) Autonomous DataFactory : high-throughput screening for large-scale data collection to inform medicine manufacture. British Journal of Pharmacy, 7 (2). ISSN 2058-8356

Maldonado, Diego A. and Vassileiou, Antony and Johnston, Blair and Florence, Alastair J. and Brown, Cameron J. (2022) Data mining crystallization kinetics. Digital Discovery, 1 (5). pp. 621-635. ISSN 2635-098X

Polyzois, Hector and Guo, Rui and Srirambhatla, Vijay K. and Warzecha, Monika and Prasad, Elke and Turner, Alice and Halbert, Gavin W. and Keating, Patricia and Price, Sarah L. and Florence, Alastair J. (2022) Crystal structure and twisted aggregates of oxcarbazepine form III. Crystal Growth and Design, 22 (7). pp. 4146-4156. ISSN 1528-7483

Chong, Magdalene and Brown, Cameron and Mustoe, Chantal and McGinty, John and Li, Wei and Pathan, Momina and Ottoboni, Sara and Prasad, Elke and Robertson, Murray and Mehta, Bhavik and McGowan, Mark and Siddique, Humera and Raval, Vishal and Pereira Diaz, Laura and Siddique, Mariam and Eales, William and Turner, Alice and Johnston, Blair and Robertson, John and Halbert, Gavin and Price, Chris and Benyahia, Brahim and Rielly, Chris and Sefcik, Jan and Nordon, Alison and McGlone, Thomas and Smith, Kenneth and Feilden, Helen and Houson, Ian and Florence, Alastair (2022) The CMAC MicroFactory : mefenamic acid. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Mustoe, Chantal and Brown, Cameron and Markl, Daniel and Houson, Ian and Feilden, Helen and Robertson, Murray and Florence, Alastair (2022) The CMAC quality by digital design workflow. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Pathan, Momina and McGinty, John and Chong, Magdalene W. S. and Robertson, Murray and Ottoboni, Sara and Li, Wei and McGowan, Mark and Ojo, Ebenezer and Anwar, Ali and Brown, Cameron J. and Sefcik, Jan and Nordon, Alison and Johnston, Blair and Price, Chris J. and Rielly, Chris D. and Benyahia, Brahim and Houson, Ian and Florence, Alastair J (2022) Crystallisation MicroFactory test bed. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Pickles, Thomas and Mustoe, Chantal and Brown, Cameron and Florence, Alastair (2022) Developing an autonomous DataFactory workflow for smallscale batch cooling crystallisation with the antiviral lamivudine. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Tanveer, Saadia and Oswald, Iain D. H. and Florence, Alastair J. (2022) Discovery and applications of a novel solid-state arrangement : water bridge salt form. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Josifovic, Aleksander and Barrera, Maria and Brown, Cameron and Johnston, Blair and Robertson, John and Florence, Alastair (2022) In-line process reactor test bed & sensor development. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Srirambhatla, Vijay K and Johnston, Blair and Florence, Alastair (2022) Machine learning workflows to predict crystallisability, glass forming ability, mechanical properties of small organic compounds. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Johnston, Jenna and Brown, Cameron and Florence, Alastair (2022) Mechanistic model development of α-lactose monohydrate crystallisation. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Raval, Vishal and McGowan, Mark and Smith, Kenneth and Florence, Alastair (2022) Particle engineering-size controlled spherical agglomeration of benzoic acid. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Nakapraves, Siya and Warzecha, Monika and Mustoe, Chantal and Florence, Alastair J. (2022) Prediction of mefenamic acid crystal shape by random forest classification. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Pereira-Diaz, Laura and Brown, Cameron J. and Florence, Alastair J. (2022) Prediction of powder flow of pharmaceutical materials using machine learning. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Mustoe, Chantal and Pickles, Thomas and Brown, Cameron and Florence, Alastair (2022) Towards an autonomous DataFactory for the small-batch cooling crystallisation of active pharmaceutical ingredients. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Creswick, Jack and Raval, Vishal and Florence, Alastair and Markl, Daniel (2022) Understanding the effect of spherical agglomeration on tablet manufacturability and performance. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Barrera, Maria Cecilia and Josifovic, Aleksander and Robertson, John and Johnston, Blair and Brown, Cameron and Florence, Alastair (2022) Using machine learning to predict residence time distributions in Coiled Flow Inverter (CFI) reactors. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Siddique, H. and Hamilton, N. and Robertson, M. and Warzecha, M. and Smith, K. and Brown, C. and Johnston, B. and Florence, A. J. and Douieb, S. and Hadjittofis, E. and Assaf, G. and Carly, N. and Pasha, M. and Cocchini, U. and Mantanus, J. (2022) A crystallisation development workflow for the manufacturability improvement of active pharmaceutical ingredients. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Vassileiou, Antony D. and Robertson, Murray N. and Wareham, Bruce G. and Soundaranathan, Mithushan and Ottoboni, Sara and Florence, Alastair J. and Hartwig, Thoralf and Johnston, Blair F. (2022) A unified AI framework for solubility prediction across organic solvents. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

Sheridan, Rachel and Cardona, Javier and Tachtatzis, Christos and Chen, Yi-Chieh and Cleary, Alison and Briggs, Naomi E. B. and Florence, Alastair and Atkinson, Robert and Michie, Craig and Andonovic, Ivan and Sefcik, Jan (2022) Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging. Chemical Engineering Science, 252. 117188. ISSN 0009-2509

Doerr, Frederik J. S. and Brown, Cameron J. and Florence, Alastair J. (2022) Direct image feature extraction and multivariate analysis for crystallisation process characterisation. Crystal Growth and Design, 22 (4). pp. 2105-2116. ISSN 1528-7483

2021

Yang, Yihui and Ahmed, Bilal and Mitchell, Christopher and Quon, Justin L. and Siddique, Humera and Houson, Ian and Florence, Alastair J. and Papageorgiou, Charles D. (2021) Investigation of wet milling and indirect ultrasound as means for controlling nucleation in the continuous crystallization of an active pharmaceutical ingredient. Organic Process Research and Development, 25 (9). pp. 2119-2132. ISSN 1083-6160

Briggs, Naomi E. B. and McGinty, John and McCabe, Callum and Raval, Vishal and Sefcik, Jan and Florence, Alastair J. (2021) Heat transfer and residence time distribution in plug flow continuous oscillatory baffled crystallisers. ACS Omega, 6 (28). pp. 18352-18363. ISSN 2470-1343

Warzecha, Monika and Florence, Alastair J. and Vekilov, Peter G. (2021) The ambiguous functions of the precursors that enable nonclassical modes of olanzapine nucleation and growth. Crystals, 11 (7). 738. ISSN 2073-4352

Piotrowska, Roxana and Hesketh, Travis and Wang, Haozhen and Martin, Alan R. G. and Bowering, Deborah and Zhang, Chunqiu and Hu, Chunhua T. and McPhee, Scott A. and Wang, Tong and Park, Yaewon and Singla, Pulkit and McGlone, Thomas and Florence, Alastair and Tuttle, Tell and Ulijn, Rein V. and Chen, Xi (2021) Mechanistic insights of evaporation-induced actuation in supramolecular crystals. Nature Materials, 20. 403–409. ISSN 1476-1122

2020

Doerr, Frederik J. S. and Burns, Lee J. and Lee, Becky and Hinds, Jeremy and Davis-Harrison, Rebecca L. and Frank, Scott A. and Florence, Alastair J. (2020) Peptide isolation via spray drying : particle formation, process design and implementation for the production of spray dried glucagon. Pharmaceutical Research, 37 (12). 255. ISSN 0724-8741

Doerr, Frederik J.S. and Florence, Alastair J. (2020) A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations [Video Abstract]. Elsevier, Amsterdam.

Doerr, Frederik J.S. and Florence, Alastair J. (2020) A micro-XRT image analysis and machine learning methodology for the characterisation of multi- particulate capsule formulations. International Journal of Pharmaceutics: X, 2. 100041. ISSN 2590-1567

Ojo, Ebenezer and Osman, Musab and Mnemo, Mitchelle and Anwar, Ali and Houson, Ian and O'Meahdra, Ruairi and Berthold, Schenkel and Florence, Alastair (2020) Multistage, multi-zones antisolvent-cooling crystallisation of a proprietary API : experimental comparison of effect of geometry and hydrodynamics in four batch crystallisers. In: CMAC Annual Open Day, 2020-10-21 - 2020-10-22, Virtual event.

Warzecha, Monika and Verma, Lakshmanji and Johnston, Blair F. and Palmer, Jeremy C. and Florence, Alastair J. and Vekilov, Peter G. (2020) Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers. Nature Chemistry, 12 (10). pp. 914-920. ISSN 1755-4330

Brown, Cameron and Maldonado, Diego and Vassileiou, Antony and Johnston, Blair and Florence, Alastair (2020) Data mining crystallization kinetics. Preprint / Working Paper. ChemRxiv.

Piotrowska, Roxana and Hesketh, Travis and Wang, Haozhen and Martin, Alan R. G. and Bowering, Deborah and Zhang, Chunqiu and Hu, Chunhua T. and McPhee, Scott and Wang, Tong and Park, Yaewon and Singla, Pulkit and McGlone, Thomas and Florence, Alastair and Tuttle, Tell and Ulijn, Rein V. and Chen, Xi (2020) Humidity responsive tripeptide crystals. In: Virtual Symposium: Systems Chemistry, 2020-05-18 - 2020-05-20, Advanced Science Research Center, City University New York.

Solomun, Jana I. and Totten, John D. and Wongpinyochit, Thidarat and Florence, Alastair J. and Seib, F. Philipp (2020) Manual versus microfluidic-assisted nanoparticle manufacture : impact of silk fibroin stock on nanoparticle characteristics. ACS Biomaterials Science & Engineering, 6 (5). pp. 2796-2804. ISSN 2373-9878

Raval, Vishal and Siddique, Humera and Brown, Cameron J. and Florence, Alastair J. (2020) Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC). CrystEngComm, 22 (13). pp. 2288-2296. ISSN 1466-8033

Srirambhatla, Vijay K. and Guo, Rui and Dawson, Daniel M. and Price, Sarah L and Florence, Alastair J. (2020) Reversible two-step single-crystal to single-crystal phase transitions between desloratadine forms I, II and III. Crystal Growth and Design, 20 (3). pp. 1800-1810. ISSN 1528-7483

2019

Badman, Clive and Cooney, Charles L. and Haslam, Robert T. and Florence, Alastair and Konstantinov, Konstantin and Krumme, Markus and Mascia, Salvatore and Nasr, Moheb and Trout, Bernhardt L. and Baddour, Raymond F. (2019) Why we need continuous pharmaceutical manufacturing and how to make it happen : a summary of thoughts from the international symposium on continuous manufacturing. Journal of Pharmaceutical Sciences, 108 (11). pp. 3521-3523. ISSN 0022-3549

Ojo, E. and Rayat, ACME. and Brown, C. and Price, C. and Hoare, M. and Florence, A. and Johnston, Andrea (2019) Quality by design approach for early understanding of active pharmaceutical ingredient recovery process through dead-end filtration. In: The American Association of Pharmaceutical Scientists (AAPS) 2019 PharmaSci 360, 2019-11-03 - 2019-11-06, Henry B. Gonzalez Convention Center.

Ojo, E. and Siddique, H. and Houson, I. and Brown, C. and O'Meahdra, R. and Berthold, S. and Florence, A. (2019) Enabling model-predictive design : rapid development of a PBM for an anti-solvent and cooling crystallisation in two different reactor geometries. In: American Association of Pharmaceutical Scientists PharmSci 360, 2019, 2019-11-03 - 2019-11-07.

Bordos, Ecaterina and Islam, Muhammad T. and Florence, Alastair J. and Halbert, Gavin W. and Robertson, John (2019) Use of terahertz-Raman spectroscopy to determine solubility of the crystalline active pharmaceutical ingredient in polymeric matrices during hot melt extrusion. Molecular Pharmaceutics, 16 (10). pp. 4361-4371. ISSN 1543-8384

Prasad, Elke and Islam, Muhammad T. and Goodwin, Daniel J. and Megarry, Andrew J. and Halbert, Gavin W. and Florence, Alastair J. and Robertson, John (2019) Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisol™ 15LV filaments for Fused Filament Fabrication (FFF) 3D printing. Additive Manufacturing, 29. 100776. ISSN 2214-8604

Jolliffe, Hikaru G. and Papathanasiou, Foteini and Prasad, Elke and Halbert, Gavin and Robertson, John and Brown, Cameron J. and Florence, Alastair J.; (2019) Improving the prediction of multi-component tablet properties from pure component parameters. In: 29th European Symposium on Computer Aided Chemical Engineering. Computer Aided Chemical Engineering, 46 . Elsevier, NLD, pp. 883-888. ISBN 9780128186350

Ojo, E.O. and Rayat, A. and Price, C.J. and Brown, C.J. and Hoare, M. and Johnston, A. and Florence, A.J. (2019) Unconventional ultra scale-down techniques for active pharmaceutical ingredient filtration and size reduction. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

Ojo, Ebenezer and Hosni, Zied and Onyemelukwe, Iyke and Ramakers, Lennart and Houson, Ian and Florence, Alastair (2019) Developing process understanding for continuous manufacturing of Lamivudine (Epivir®) Stable Form I. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

Polyzois, H. and Guo, R. and Warzecha, M. and Price, S. L . and Florence, A.J. (2019) Oxcarbazepine form III : observation of twisted habit in crystals of an elusive pharmaceutical polymorph. In: 50th Annual Conference of the British Association of Crystal Growth, 2019-07-09 - 2019-07-11.

Polyzois, H. and Guo, R. and Warzecha, M. and Price, S. L. and Florence, A. (2019) Polymorph screening studies of oxcarbazepine : twisted habit in crystals of the elusive form III. In: Gordon Research Conference on Crystal Growth and Assembly, 2019-06-23 - 2019-06-28, Southern New Hampshire University in Manchester.

Doerr, Frederik and Florence, Alastair (2019) Nanofocused X-ray tomography and image processing for quantitative analysis of pharmaceutical particulate solid products. In: International Congress on Particle Technology, 2019-04-09 - 2019-04-11.

Ahmed, Bilal and Brown, Cameron J. and McGlone, Thomas and Bowering, Deborah L. and Sefcik, Jan and Florence, Alastair J. (2019) Engineering of acetaminophen particle attributes using a wet milling crystallisation platform. International Journal of Pharmaceutics, 554. pp. 201-211. ISSN 1873-3476

2018

Agimelen, Okpeafoh S. and Svoboda, Vaclav and Ahmed, Bilal and Cardona, Javier and Dziewierz, Jerzy and Brown, Cameron J. and McGlone, Thomas and Cleary, Alison and Tachtatzis, Christos and Michie, Craig and Florence, Alastair J. and Andonovic, Ivan and Mulholland, Anthony J. and Sefcik, Jan (2018) Multi-sensor inline measurements of crystal size and shape distributions during high shear wet milling of crystal slurries. Advanced Powder Technology, 29 (12). pp. 2987-2995. ISSN 1568-5527

Doerr, Frederik J.S. and Oswald, Iain D.H. and Florence, Alastair J. (2018) Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography. Advanced Powder Technology, 29 (12). pp. 2996-3006. ISSN 1568-5527

Doerr, Frederik J.S. and Oswald, Iain D.H. and Florence, Alastair J. (2018) Quantitative investigation of particle formation of a model pharmaceutical formulation using single droplet evaporation experiments and X-ray tomography [Video Abstract]. Elsevier, Amsterdam.

Prasad, E. and Robertson, J. and Brown, C. and Jolliffe, H. and Florence, A. and Halbert, G. (2018) Microfactory – Blend – Compression - Performance test. In: CMAC Annual Open Day, 2018-10-25 - 2018-10-26.

Cardona, Javier and Ferreira, Carla and Svoboda, Vaclav and Ahmed, Bilal and McGinty, John and Agimelen, Okpeafoh S. and Hamilton, Andrew and Cleary, Alison and Atkinson, Robert and Michie, Craig and Marshall, Stephen and Florence, Alastair J. and Chen, Yi-Chieh and Sefcik, Jan and Andonovic, Ivan and Tachtatzis, Christos; Thorvald, Peter and Case, Keith, eds. (2018) The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry. In: Advances in Manufacturing Technology XXXII. Advances in Transdisciplinary Engineering . IOS Press, SWE, pp. 27-32. ISBN 978-1-61499-901-0

Case, David H. and Srirambhatla, Vijay K. and Guo, Rui and Watson, Rona E. and Price, Louise S. and Polyzois, Hector and Cockcroft, Jeremy K. and Florence, Alastair J. and Tocher, Derek A. and Price, Sarah L. (2018) Successful computationally directed templating of metastable pharmaceutical polymorphs. Crystal Growth and Design, 18 (9). pp. 5322-5331. ISSN 1528-7483

Brown, Cameron J. and McGlone, Thomas and Yerdelen, Stephanie and Srirambhatla, Vijay and Mabbott, Fraser and Gurung, Rajesh and Briuglia, Maria L. and Ahmed, Bilal and Polyzois, Hector and McGinty, John and Perciballi, Francesca and Fysikopoulos, Dimitris and Macfhionnghaile, Pól and Siddique, Humera and Raval, Vishal and Harrington, Tomás S. and Vassileiou, Antony D. and Robertson, Murray and Prasad, Elke and Johnston, Andrea and Johnston, Blair and Nordon, Alison and Srai, Jagjit S. and Halbert, Gavin and ter Horst, Joop H. and Price, Chris J. and Rielly, Chris D. and Sefcik, Jan and Florence, Alastair J. (2018) Enabling precision manufacturing of active pharmaceutical ingredients : workflow for seeded cooling continuous crystallisations. Molecular Systems Design & Engineering, 2018 (3). pp. 518-549. ISSN 2058-9689

Ottoboni, Sara and Chrubasik, Michael and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Robertson, Murray and Johnston, Blair and Oswald, Iain D. H. and Florence, Alastair and Price, Chris (2018) Impact of paracetamol impurities on face properties : investigating the surface of single crystals using TOF-SIMS. Crystal Growth and Design, 18 (5). 2750–2758. ISSN 1528-7483

Ahmed, Bilal and Svoboda, Vaclav and Agimelen, Okpeafoh and Cardona, Javier and Dziewierz, Jerzy and Brown, Cameron and McGlone, Thomas and Cleary, Alison and Tachtatzis, Christos and Michie, Craig and Florence, Alastair J. and Andonovic, Ivan and Mulholland, Anthony and Sefcik, Jan (2018) Monitoring API crystal breakage in wet milling using inline imaging and chord length distribution measurements. In: 8th World Congress on Particle Technology, 2018-04-22 - 2018-04-26, Orlando World Center Marriott.

Bhardwaj, Rajni M. and Reutzel-Edens, Susan M. and Johnston, Blair F. and Florence, Alastair J. (2018) A random forest model for predicting crystal packing of olanzapine solvates. CrystEngComm, 20 (28). pp. 3947-3950. ISSN 1466-8033

Doerr, Frederik and Florence, Alastair and Oswald, Iain (2018) A rational single particle design approach using an acoustic levitation system and X-ray tomography. In: 8th World Congress on Particle Technology, 2018-04-22 - 2018-04-26, Orlando World Center Marriott.

Doerr, Frederik J. S. and Florence, Alastair J. (2018) XRT : Extraction of quantitative structural descriptors from solid pharmaceutical products. In: Bruker Micro-CT User Meeting, 2018-04-16 - 2018-04-19.

Polyzois, Hector and Guo, Rui and Warzecha, Monika and Price, Sarah and Florence, Alastair (2018) Crystallisation of oxcarbazepine form III : emergence of crystals with variable twisted habit. In: BCA Spring Meeting 2018, 2018-03-26 - 2018-03-29, University of Warwick.

Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2018) Injection moulding- A novel method of solid oral dosage form manufacturing. In: Sci Formulation Forum, 2018-01-17 - 2018-01-18.

Turner, Alice J. and Halbert, Gavin W. and Florence, Alastair J. (2018) Inkjet printing of oral dosage forms to solubilize BCS Class II drugs. In: Sci Formulation Forum, 2018-01-17 - 2018-01-18.

Raza, Syed A. and Schacht, Ulrich and Svoboda, Vaclav and Edwards, Darren P. and Florence, Alastair J. and Pulham, Colin R. and Sefcik, Jan and Oswald, Iain D. H. (2018) Rapid continuous antisolvent crystallization of multi-component systems. Crystal Growth and Design, 18 (1). pp. 210-218. ISSN 1528-7483

2017

Turner, A. and Halbert, G. and Florence, A. (2017) Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs. In: AAPS Annual Meeting and Exposition 2017, 2017-11-12 - 2017-11-15, San Diego Convention Center.

Warzecha, Monika and Safari, Mohammad S. and Florence, Alastair J. and Vekilov, Peter G. (2017) Mesoscopic solute-rich clusters in olanzapine solutions. Crystal Growth and Design. pp. 6668-6676. ISSN 1528-7483

Warzecha, Monika and Guo, Rui and Bhardwaj, Rajni M. and Reutzel-Edens, Susan M. and Price, Sarah L. and Lamprou, Dimitrios A. and Florence, Alastair J. (2017) Direct observation of templated two-step nucleation mechanism during olanzapine hydrate formation. Crystal Growth and Design, 17 (12). pp. 6382-6393. ISSN 1528-7483

Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2017) Solid oral dosage form manufacturing using injection moulding. In: C-SOPS Fall 2017 Industry Meeting, 2017-10-16 - 2017-10-17, Busch Campus, Rutgers University.

Brown, Cameron and McGlone, Thomas and Florence, Alastair; Kleinebudde, Peter and Khinast, Johannes and Rantanen, Jukka, eds. (2017) Continuous crystallisation. In: Continuous Manufacturing of Pharmaceuticals. John Wiley & Sons Inc., Hoboken, pp. 169-226. ISBN 978-1-119-00135-5

Ojo, Ebenezer and Rayat, Andrea and Johnston, Andrea and Price, Chris John and Price, Chris and Florence, Alastair and Hoare, Mike (2017) Process development for recovery of crystals using DoE. In: British Association of Crystal Growth 50th Annual Conference, 2019-07-09 - 2019-07-11, Sussex Place.

Warzecha, Monika and Vekilov, Peter G. and Florence, Alastair (2017) The solute-rich mesoscopic precursors of crystal nuclei of olanzapine solid forms. In: 48th BACG Annual Conference, 2017-06-27 - 2017-06-30, University of Manchester.

Doerr, Frederik and Brammer, Elanor and Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2017) Morphological characterisation of solid pharmaceutical products using X-ray tomography. In: Bruker micro-CT User Meeting, 2017-06-12 - 2017-06-15.

S. de Moraes, Lygia and Edwards, Darren and Florence, Alastair J. and Johnston, Andrea and Johnston, Blair F. and Morrison, Catriona A. and Kennedy, Alan R. (2017) Aqueous solubility of organic salts. Investigating trends in a systematic series of 51 crystalline salt forms of methylephedrine. Crystal Growth and Design, 17 (6). pp. 3277-3286. ISSN 1528-7483

Halliwell, Rebecca A. and Bhardwaj, Rajni M. and Brown, Cameron and Briggs, Naomi E. B. and Dunn, Jaclyn and Robertson, John and Nordon, Alison and Florence, Alastair J. (2017) Spray drying as a reliable route to produce metastable carbamazepine form IV. Journal of Pharmaceutical Sciences, 106 (7). pp. 1874-1880. ISSN 0022-3549

Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2017) Solid oral dosage form manufacturing using injection moulding. In: CMAC Annual Open Day 2017, 2017-03-23 - 2017-03-24, Technology and Innovation Centre, University of Strathclyde.

Ejim, Louisa N. and Yerdelen, Stephanie and McGlone, Thomas and Onyemelukwe, I and Johnston, Blair and Florence, Alastair J. and Reis, Nuno M. (2017) A factorial approach to understanding the effect of inner geometry of baffled meso-scale tubes on solids suspension and axial dispersion in continuous, oscillatory liquid-solid plug flows. Chemical Engineering Journal, 308. 669–682. ISSN 1385-8947

2016

Wood, Sarahjane and Halbert, G. W. and Florence, A. (2016) Achieving immediate release dosage forms using DoE and injection moulding. In: First I2APM International Symposium, 2016-11-30 - 2016-12-01, University of Strathclyde.

Islam, M. T. and Robertson, J. and Tahir, F. and Florence, A. (2016) Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). In: 7th APS International PharmSci Conference, 2016-09-05 - 2016-09-07, University of Strathclyde.

Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2016) Injection moulding : a novel approach to the manufacture of homogenous immediate release solid oral dosage forms. In: 7th APS International PharmSci Conference, 2016-09-05 - 2016-09-07, University of Strathclyde.

Turner, Alice J. and Halbert, Gavin W. and Florence, Alastair J. (2016) Inkjet printing oral dosage forms. In: 7th APS International PharmSci Conference, 2016-09-05 - 2016-09-07, University of Strathclyde.

Islam, M.T. and Robertson, J. and Florence, A.J. (2016) Initial assessment of hot-melt extrusion for processing API with a wide range of physical properties to form consistent solid dispersion : HPMC-Affinisol paracetamol system. In: 2016 AAPS Annual meeting and exposition, 2016-11-13 - 2016-11-17, Colorado Convention Center. (In Press)

Ottoboni, Sara and Chrubasik, Michael and Mir Bruce, Layla and Nguyen, Thai Thu Hien and Johnston, Blair and Florence, Alastair and Price, Chris John (2016) The impact of paracetamol impurities on face-specific properties : investigating the surface of single crystals using TOF-SIMS. In: Crystal Growth of Organic Materials, 2016-06-26 - 2016-06-30, University of Leeds.

Srirambhatla, Vijay and Guo, Rui and Price, Sarah L. and Florence, Alastair James (2016) Isomorphous template induced crystallisation : a robust method for the targeted crystallisation of computationally predicted metastable polymorphs. Chemical Communications, 52 (46). pp. 7384-7386. ISSN 1359-7345

Yang, Huaiyu and Yu, Xi and Raval, Vishal and Makkawi, Yassir and Florence, Alastair (2016) Effect of oscillatory flow on nucleation kinetics of butyl paraben. Crystal Growth and Design, 16 (2). pp. 875-886. ISSN 1528-7483

Bhardwaj, Rajni M. and Yang, Huaiyu and Florence, Alastair J. (2016) Crystal structure of the co-crystal butylparaben– isonicotinamide (1/1). Acta Crystallographica Section E: Structure Reports, E72 (1). pp. 53-55. ISSN 1600-5368

2015

Siddique, Humera and Brown, Cameron J. and Houson, Ian and Florence, Alastair J. (2015) Establishment of a continuous sonocrystallization process for lactose in an oscillatory baffled crystallizer. Organic Process Research and Development, 19 (12). pp. 1871-1881. ISSN 1083-6160

Briggs, Naomi E. B. and Schacht, Ulrich and Raval, Vishal and McGlone, Thomas and Sefcik, Jan and Florence, Alastair J. (2015) Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer. Organic Process Research and Development, 19 (12). 1903−1911. ISSN 1083-6160

McGlone, Thomas and Briggs, Naomi E. B. and Clark, Catriona A. and Brown, Cameron J. and Sefcik, Jan and Florence, Alastair J. (2015) Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization. Organic Process Research and Development, 19 (9). 1186–1202. ISSN 1083-6160

Tachtatzis, Christos and Sheridan, Rachel and Michie, Craig and Atkinson, Robert C. and Cleary, Alison and Dziewierz, Jerzy and Andonovic, Ivan and Briggs, Naomi E.B. and Florence, Alastair J. and Sefcik, Jan (2015) Image-based monitoring for early detection of fouling in crystallisation processes. Chemical Engineering Science, 133. pp. 82-90. ISSN 0009-2509

Robertson, Murray and McGlone, Thomas and Johnston, Andrea and Florence, Alastair and Johnston, Blair and Dziewierz, Jerzy and Tachtatzis, Christos and Cleary, Alison and Gachagan, Anthony and Andonovic, Ivan and Sefcik, Jan (2015) Developing a data acquisition, analysis and reporting system for an academic research centre. In: ACM International Conference on Multimedia Retrieval (ICMR), 2015-06-23 - 2015-06-26.

Warzecha, Monika and Bhardwaj, Rajni M. and Reutzel-Edens, Susan and Lamprou, Dimitrios and Florence, Alastair (2015) Atomic force microscopy studies on two-step nucleation and epitaxial growth. In: 46th BACG Annual Conference, 2015-06-21 - 2015-06-23, Queen Mary University.

Bhardwaj, Rajni M. and Johnston, Andrea and Johnston, Blair F. and Florence, Alastair J. (2015) A random forest model for predicting the crystallisability of organic molecules. CrystEngComm, 17 (23). pp. 4272-4275. ISSN 1466-8033

Bhardwaj, Rajni M. and Raval, Vishal and Oswald, Iain D. H. and Florence, Alastair J. (2015) Crystal structure of a mixed solvated form of amoxapine acetate. Acta Crystallographica Section E: Structure Reports, 71 (2). pp. 139-141. ISSN 1600-5368

2014

Delori, Amit and Maclure, Pauline and Bhardwaj, Rajni M. and Johnston, Andrea and Florence, Alastair J. and Sutcliffe, Oliver B. and Oswald, Iain D. H. (2014) Drug solid solutions - a method for tuning phase transformations. CrystEngComm, 16 (26). pp. 5827-5831. ISSN 1466-8033

Zhao, Lihua and Raval, Vishal and Briggs, Naomi E. B. and Bhardwaj, Rajni M. and McGlone, Thomas and Oswald, Iain D. H. and Florence, Alastair J. (2014) From discovery to scale-up: alpha-lipoic acid : nicotinamide co-crystals in a continuous oscillatory baffled crystalliser. CrystEngComm, 16 (26). pp. 5769-5780. ISSN 1466-8033

McKellar, Scott C. and Kennedy, Alan R. and McCloy, Neil C. and McBride, Eileen and Florence, Alastair J. (2014) Formulation of liquid propofol as a cocrystalline solid. Crystal Growth and Design, 14 (5). pp. 2422-2430. ISSN 1528-7483

2013

Bhardwaj, Rajni M. and Johnston, Blair F. and Oswald, Iain D. H. and Florence, Alastair J. (2013) A complementary experimental and computational study of loxapine succinate and its monohydrate. Acta Crystallographica Section C: Crystal Structure Communications, 69 (11). pp. 1273-1378. ISSN 0108-2701

Braun, Doris E and Bhardwaj, Rajni M. and Arlin, Jean-Baptiste and Florence, Alastair J. and Kahlenberg, Volker and Griesser, Ulrich J. and Tocher, Derek A. and Price, Sarah L. (2013) Absorbing a little water : the structural, thermodynamic, and kinetic relationship between pyrogallol and its tetarto-hydrate. Crystal Growth and Design, 13 (9). pp. 4071-4083. ISSN 1528-7483

Bhardwaj, Rajni M and Price, Louise S. and Price, Sarah L. and Reutzel-Edens, Susan M. and Miller, Gary J. and Oswald, Iain D. H. and Johnston, Blair F. and Florence, Alastair J. (2013) Exploring the experimental and computed crystal energy landscape of olanzapine. Crystal Growth and Design, 13 (4). pp. 1602-1617. ISSN 1528-7483

Florence, Alastair J. (2013) 4th European conference for crystal growth-crystallisation in focus : from fundamentals to application. CrystEngComm, 15 (12). p. 2174. ISSN 1466-8033

Smart, P. and Mason, C A and Loader, J R and Meijer, Anthony J.H.M. and Florence, Alastair and Shankland, Kenneth and Fletcher, Ashleigh and Thompson, S P and Brunelli, Michela and Hill, A H and Brammer, Lee (2013) Zipping and unzipping of a paddlewheel metal-organic framework to enable two-step synthetic and structural transformation. Chemistry - A European Journal, 19 (11). pp. 3552-3557. ISSN 1521-3765

Vitorica-Yrezabal, Iñigo and Mínguez Espallargas, Guillermo and Soleimannejad, Janet and Florence, Alastair and Fletcher, Ashleigh and Brammer, Lee (2013) Chemical transformations of a crystalline coordination polymer : a multi-stage solid–vapour reaction manifold. Chemical Science, 4 (2). pp. 696-708. ISSN 2041-6539

Braun, Doris E and Bhardwaj, Rajni M. and Florence, Alastair J. and Tocher, Derek A. and Price, Sarah L. (2013) Complex polymorphic system of gallic acid-five monohydrates, three anhydrates, and over 20 solvates. Crystal Growth and Design, 13 (1). pp. 19-23. ISSN 1528-7483

2012

Florence, Alastair and Oswald, Iain and Miglani Bhardwaj, Rajni (2012) 6-Methyl-1,3,5-triazine-2,4-diamine butane-1,4-diol monosolvate. Acta Crystallographica Section E: Structure Reports, E68 (12). o3377. ISSN 1600-5368

McKellar, Scott C and Urquhart, Andrew J and Lamprou, Dimitrios A and Florence, Alastair J (2012) Polymer templating of supercooled indomethacin for polymorph selection. ACS Combinatorial Science, 14 (3). pp. 155-159.

2011

Iski, Erin V. and Johnston, Blair F and Florence, Alastair J and Sykes, E. Charles H. and Urquhart, Andrew J (2011) Carbamazepine on a carbamazepine monolayer forms unique 1D supramolecular assemblies. Chemical Communications, 47 (34). pp. 9627-9629.

Fielding, Lee and McKellar, Scott C and Florence, Alastair J (2011) Precision studies in supramolecular chemistry : a 1H NMR study of hydroxymethoxyacetophenone/β-cyclodextrin complexes. Magnetic Resonance in Chemistry, 49 (7). pp. 405-412.

Arlin, Jean-Baptiste and Price, Louise S and Price, Sarah L and Florence, Alastair J (2011) A strategy for producing predicted polymorphs : catemeric carbamazepine form V. Chemical Communications, 47 (25). pp. 7074-7076.

Arlin, Jean-Baptiste and Florence, Alastair J. and Johnston, Andrea and Kennedy, Alan R. and Miller, Gary J. and Patterson, Kirsty (2011) Systematic data set for structure-property investigations : solubility and solid-state structure of alkaline earth metal salts of benzoates. Crystal Growth and Design, 11 (4). pp. 1318-1327. ISSN 1528-7483

Fabbiani, Francesca P A and Arlin, Jean Baptiste and Buth, Gernot and Dittrich, Birger and Florence, Alastair J and Herbst-Irmer, Regine and Sowa, Heidrun (2011) Intermolecular interactions, disorder and twinning in ciprofloxacin-2,2-difluoroethanol (2/3) and ciprofloxacin-water (3/14.5). Acta Crystallographica Section C: Crystal Structure Communications, 67 (3). o120-o124.

Johnston, Andrea and Bardin, Julie and Johnston, Blair and Fernandes, Phillippe and Kennedy, Alan and Price, Sarah L. and Florence, Alastair (2011) Experimental and predicted crystal energy landscapes of chlorothiazide. Crystal Growth and Design, 11 (2). pp. 405-413. ISSN 1528-7483

Dykhne, Timur and Taylor, Ryan and Florence, Alastair and Billinge, Simon J L (2011) Data requirements for the reliable use of atomic pair distribution functions in amorphous pharmaceutical fingerprinting. Pharmaceutical Research, 28 (5). pp. 1041-1048.

Braun, Doris E and Karamertzanis, Panagiotis G and Arlin, Jean-Baptiste and Florence, Alastair J and Kahlenberg, Volker and Tocher, Derek A and Griesser, Ulrich J and Price, Sarah L. (2011) Solid-state forms of β-resorcylic acid how exhaustive should a polymorph screen be? Crystal Growth and Design, 11 (1). pp. 210-220.

Espallargas, G. M. and Florence, A. J. and van de Streek, J. and Brammer, L. (2011) Different structural destinations: comparing reactions of [CuBr2(3-Brpy)(2)] crystals with HBr and HCl gas. CrystEngComm (13). pp. 4400-4404. ISSN 1466-8033

Braun, D. E. and Ardid-Candel, M. and DOria, E. and Karamertzanis, P. G. and Arlin, J. B. and Florence, A. J. and Jones, A. G. and Price, S. L. (2011) Racemic Naproxen: A Multidisciplinary Structural and Thermodynamic Comparison with the Enantiopure Form. Crystal Growth and Design, 11. pp. 5659-5669. ISSN 1528-7483

2010

Mínguez Espallargas, Guillermo and van de Streek, Jacco and Fernandes, Philippe and Florence, Alastair J and Brunelli, Michela and Shankland, Kenneth and Brammer, Lee (2010) Mechanistic insights into a gas-solid reaction in molecular crystals : the role of hydrogen bonding. Angewandte Chemie International Edition, 49 (47). pp. 8892-8896. ISSN 1521-3773

Iski, Erin V. and Johnston, Blair F. and Florence, Alastair J. and Urquhart, Andrew J. and Sykes, E. Charles H. (2010) Surface-mediated two-dimensional growth of the pharmaceutical carbamazepine. ACS Nano, 4 (9). pp. 5061-5068. ISSN 1936-0851

Antoniadis, Constantinos D and D'Oria, Emiliana and Karamertzanis, Panagiotis G and Tocher, Derek A and Florence, Alastair J and Price, Sarah L. and Jones, Alan G (2010) A computationally inspired investigation of the solid forms of (R)-1-phenylethylammonium-(S)-2-phenylbutyrate. Chirality, 22 (4). pp. 447-455.

Billinge, Simon J L and Dykhne, Timur and Juhas, Pavol and Bozin, Emil and Taylor, Ryan and Florence, Alastair and Shankland, Kenneth (2010) Characterisation of amorphous and nanocrystalline molecular materials by total scattering. CrystEngComm, 12 (5). pp. 1366-1368. ISSN 1466-8033

Arlin, Jean-Baptiste and Johnston, Andrea and Miller, Gary J. and Kennedy, Alan and Price, Sarah L. and Florence, Alastair (2010) A predicted dimer-based polymorph of 10,11-dihydrocarbamazepine (Form IV). CrystEngComm, 12 (1). pp. 64-66. ISSN 1466-8033

2009

Bardin, J. and Florence, A.J. and Arlin, J.B. and Kennedy, A.R. and Wong, L.V. (2009) 3-aminocarbonylpyridinium difluoroacetate at 123 k. Acta Crystallographica Section E: Structure Reports, 65. O2896-U2160. ISSN 1600-5368

McConville, Jason T. and Hodges, Lee Ann and Jones, Tamara and Band, Janet P. and O'Mahony, Bridget and Lindsay, Blythe and Ross, Alistair C. and Florence, Alastair J. and Stanley, Adrian J. and Humphrey, Michael J. and Wilson, Clive and Stevens, Howard (2009) A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers. Journal of Pharmaceutical Sciences, 98 (11). pp. 4251-4263. ISSN 0022-3549

Florence, A.J.; Brittain, Harry G., ed. (2009) Approaches to high-throughput physical form screening and discovery. In: Polymorphism in Pharmaceutical Solids, Second Edition. Informa Healthcare. ISBN 9781420073225

Kennedy, Alan R. and Florence, Alastair J. and McInnes, Fiona J. and Wheate, Nial J. (2009) A chemical preformulation study of a host-guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery. Dalton Transactions, 2009 (37). pp. 7695-7700. ISSN 1472-7773

Florence, A. J. and Bardin, J. and Johnston, B. and Shankland, N. and Griffin, T. A. N. and Shankland, K.; Göbel, Herbert, ed. (2009) Structure determination from powder data : Mogul and CASTEP. In: Eleventh European Powder Diffraction Conference. Zeitschrift fur Kristallografie, 30 . De Gruyter, Berlin, Germany, pp. 215-220. ISBN 9783486992588

Florence, A.J.; Florence, Alexander and Siepmann, Juergen, eds. (2009) The solid state. In: Modern pharmaceutics, Fifth Edition. Informa Healthcare, New York, USA. ISBN 9781420065657

Bardin, J. and Kennedy, A.R. and Wong, L.V. and Johnston, B.F. and Florence, A.J. (2009) Nicotinamide-2,2,2-trifluoroethanol (2/1). Acta Crystallographica Section E: Structure Reports, 65 (4). o727-o728. ISSN 1600-5368

Thomas, Lynne H and Florence, Alastair and Wilson, Chick C. (2009) Hydrogen atom behaviour imaged in a short intramolecular hydrogen bond using the combined approach of X-ray and neutron diffraction. New Journal of Chemistry, 33 (12). pp. 2486-2490. ISSN 1144-0546

Shankland, K. and Griffin, T.A.N. and van de Streek, J. and Cole, Jared H. and Shankland, N. and Florence, A.J. and David, W.I.F. (2009) Large-scale distributed computing for accelerated structure solution. Zeitschrift fur Kristallografie, 30. pp. 227-232. ISSN 0044-2968

Mansour, H. and McInnes, F.J. and Florence, A.J. and Mullen, A. (2009) The role of lyophilisation in the enhancement of glibenclamide release from hard gelatin capsules. Journal of Pharmacy and Pharmacology, 61 (S1). A38-A39. ISSN 0022-3573

2008

Johnston, A. and Florence, A.J. and Miller, Gary J. and Kennedy, A.R. and Bedford, Colin T. (2008) Cytenamide-formic acid (1/1). Acta Crystallographica Section E: Structure Reports, 64. pp. 1379-1380. ISSN 1600-5368

Johnston, Andrea and Florence, Alastair J. and Fabianni, Francesca J. A. and Shankland, Kenneth and Bedford, Colin T. and Bardin, Julie (2008) Cytenamide trifluoroacetic acid solvate. Acta Crystallographica Section E: Structure Reports, 64 (7). pp. 1215-1216. ISSN 1600-5368

Johnston, A. and Florence, A.J. and Fabbiani, F.J.A. and Shankland, K. and Bedford, C.T. (2008) Cytenamide-butyric acid (1/1). Acta Crystallographica Section E: Structure Reports, 64 (7). O1295-U2200. ISSN 1600-5368

Johnston, Andrea and Florence, A.J. and Kennedy, A.R. (2008) Chlorothiazide-pyridine (1/3). Acta Crystallographica Section E: Structure Reports, 64 (6). pp. 1105-1106. ISSN 1600-5368

Johnston, Andrea and Florence, A.J. and Fabianni, F.J.A. and Shankland, K. and Bedford, C.T. (2008) Cytenamide acetic acid solvate. Acta Crystallographica Section E: Structure Reports, 64 (6). pp. 1175-1176. ISSN 1600-5368

Fernandes, P. and Florence, A.J. and Fabbiani, F. and David, W.I.F. and Shankland, K. (2008) Urea-N,N-dimethylacetamide (1/1). Acta Crystallographica Section E: Structure Reports, 64 (2). o355-o355. ISSN 1600-5368

Fabbiani, Francesca P.A. and Dittrich, Birger and Florence, A.J. and Gelbrich, T. and Hursthouse, M.B. and Kuhs, Werner F. and Shankland, N. and Sowa, Heidrum (2008) Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure. CrystEngComm, 11. pp. 1396-1406. ISSN 1466-8033

Johnston, Andrea and Florence, A.J. and Fabbiani, F.J.A. and Shankland, K. and Bedford, C.T. (2008) Cytenamide-1,4-dioxane (2/1). Acta Crystallographica Section E: Structure Reports, 64 (7). pp. 1345-1346. ISSN 1600-5368

Johnston, A. and Johnston, B.F. and Kennedy, A.R. and Florence, A.J. (2008) Targeted crystallisation of novel carbamazepine solvates based on a retrospective random forest classification. CrystEngComm, 10 (1). pp. 23-25. ISSN 1466-8033

Florence, A.J. and Bedford, C.T. and Fabbiani, F.P.A. and Shankland, K. and Gelbrich, T. and Hursthouse, M.B. and Shankland, N. and Johnston, A. (2008) Two-dimensional similarity between forms I and II of cytenamide, a carbamazepine analogue. CrystEngComm, 10. pp. 811-813. ISSN 1466-8033

Florence, A.J. and Shankland, K. and Gelbrich, T. and Hursthouse, M.B. and Shankland, N. and Johnston, Andrea and Fernandes, P. and Leech, C.K. (2008) A catemer-to-dimer structural transformation in cyheptamide. CrystEngComm, 10. pp. 26-28. ISSN 1466-8033

Fernandes, P. and Shankland, K. and David, W.I.F. and Markvardsen, A.J. and Florence, A.J. and Shankland, N. and Leech, C.K. (2008) A differential thermal expansion approach to crystal structure determination from powder diffraction data. Journal of Applied Crystallography, 41 (6). pp. 1089-1094. ISSN 0021-8898

Barnett, S.A. and Johnston, Andrea and Florence, A.J. and Price, Sarah L. and Tocherr, Derek A. (2008) A systematic experimental and theoretical study of the crystalline state of six chloronitrobenzenes. Crystal Growth and Design, 8 (1). pp. 24-36. ISSN 1528-7483

2007

Johnston, Andrea and Florence, Alastair J. and Kennedy, Alan R. (2007) Chlorothiazide formic acid solvate (1/2). Acta Crystallographica Section E: Structure Reports, 63. o4021. ISSN 1600-5368

Johnston, Andrea and Florence, Alastair J. and Fernandes, Philippe and Shankland, Norman and Kennedy, Alan R. (2007) 10,11-dihydrocarbamazepine-form-amide solvate (1/1). Acta Crystallographica Section E: Structure Reports, 63. O3888-U3750. ISSN 1600-5368

Johnston, Andrea and Florence, Alastair J. and Fernandes, Philippe and Kennedy, Alan R. (2007) Chlorothiazide N,N-dimethylacetamidedisolvate. Acta Crystallographica Section E: Structure Reports, 63. O2422-U770. ISSN 1600-5368

Johnston, Andrea and Florence, Alastair J. and Fernandes, Philippe and Kennedy, Alan R. (2007) Chlorothiazide dimethyl sulfoxide solvate. Acta Crystallographica Section E: Structure Reports, 63. O2423-U781. ISSN 1600-5368

Johnston, Andrea and Florence, Alastair J. and Shankland, Norman and Kennedy, Alan R. and Shankland, K. and Price, Sarah L. (2007) Crystallization and crystal energy landscape of hydrochlorothiazide. Crystal Growth and Design, 7 (4). pp. 705-712. ISSN 1528-7483

Hulme, Ashley T. and Johnston, Andrea and Florence, Alastair J. and Fernandes, Phillipe and Shankland, Kenneth and Bedford, Colin T. and Welch, Gareth W. A. and Sadiq, Ghazala and Haynes, Delia A. and Motherwell, W. D. Samuel and Tocher, Derek A. and Price, Sarah L. (2007) Search for a predicted hydrogen bonding motif : a multidisciplinary investigation into the polymorphism of 3-Azabicyclo[3.3.1]nonane-2,4-dione. Journal of American Chemical Society, 129 (12). pp. 3649-3657. ISSN 1520-5126

Johnston, Andrea and Florence, Alastair J. and Fernandes, Philippe and Shankland, Norman and Kennedy, Alan R. (2007) 10,11-dihydrocarbamazepine formic acid solvate. Acta Crystallographica Section E: Structure Reports, 63 (3). o1469-o1470. ISSN 1600-5368

2006

Johnston, Andrea and Florence, Alastair J. and Fernandes, Philippe and Shankland, Norman and Kennedy, Alan R. (2006) 10,11-Dihydrocarbamazepine-acetic acid (1/1). Acta Crystallographica Section E: Structure Reports, 62. O5361-O5362. ISSN 1600-5368

Johnston, Andrea and Florence, Alastair J. and Kennedy, Alan R. (2006) Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate. Acta Crystallographica Section E: Structure Reports, 62. O5169-O5171. ISSN 1600-5368

Florence, Alastair J. and Johnston, Andrea and Price, Sarah L. and Nowell, Harriott and Kennedy, Alan R. and Shankland, Norman (2006) An automated parallel crystallisation search for predicted crystal structures and packing motifs of carbamazepine. Journal of Pharmaceutical Sciences, 95 (9). pp. 1918-1930. ISSN 0022-3549

Johnston, Andrea and Florence, Alastair J. and Kennedy, Alan R. (2006) Hydrochlorothiazide N,N-dimethylacetamide disolvate. Acta Crystallographica Section E: Structure Reports, 62. O2926-O2928. ISSN 1600-5368

Johnston, A and Florence, A J and Kennedy, A R (2006) Hydrochlorothiazide dimethyl sulfoxide solvate. Acta Crystallographica Section E: Structure Reports, 62. O2288-O2290. ISSN 1600-5368

Johnston, A and Florence, A J and Kennedy, A R (2006) Hydrochlorothiazide N,N-dimethylformamide solvate. Acta Crystallographica Section E: Structure Reports, 62. O1730-O1732. ISSN 1600-5368

Florence, A.J. and Leech, C.K. and Shankland, N. and Shankland, K. and Johnston, A. (2006) Control and prediction of packing motifs: a rare occurrence of carbamazepine in a catemeric configuration. CrystEngComm, 8. pp. 746-747. ISSN 1466-8033

Espallargas, G.M. and Brammer, L. and van de Streek, J. and Shankland, K. and Florence, A.J. and Adams, H. (2006) Reversible extrusion and uptake of HCl molecules by crystalline solids involving coordination bond cleavage and formation. Journal of American Chemical Society, 128 (30). pp. 9584-85. ISSN 1520-5126

2005

Barnett, S.A. and Johnston, A. and Florence, A.J. and Kennedy, A.R. (2005) 3,4-Dichloro-1-nitro­benzene-1,4-dioxane (4/1). Acta Crystallographica Section E: Structure Reports, 61 (11). o3666-o3667. ISSN 1600-5368

Johnston, A and Florence, A J and Kennedy, A R (2005) Hydrochlorothiazide-1,4-dioxane(1/1). Acta Crystallographica Section E: Structure Reports, 61. O2573-O2575. ISSN 1600-5368

Johnston, A and Florence, A J and Kennedy, A R (2005) Hydrochlorothiazide-aniline (1/1). Acta Crystallographica Section E: Structure Reports, 61. O2520-O2522. ISSN 1600-5368

Barnett, S.A. and Johnston, A. and Florence, A. and Kennedy, A.R. (2005) 3,4-Dichloro-1-nitrobenzene-aniline (2/1). Acta Crystallographica Section E: Structure Reports, 61 (7). o2318-o2319. ISSN 1600-5368

Johnston, A and Florence, A J and Kennedy, A R (2005) Carbamazepine furfural hemisolvate. Acta Crystallographica Section E: Structure Reports, 61. O1777-O1779. ISSN 1600-5368

Johnston, A. and Florence, A. and Kennedy, A.R. (2005) Carbamazepine N,N-dimethylformamide solvate. Acta Crystallographica Section E: Structure Reports, 61 (5). o1509-o1511. ISSN 1600-5368

Florence, A.J. and Shankland, N. and Shankland, K. and David, W.I.F. and Pidcock, E. and Xu, X. and Johnston, A. and Kennedy, A.R. and Cox, P.J. and Evans, J.S.O. and Steele, G. and Cosgrove, S.D. and Frampton, C.S. (2005) Solving molecular crystal structures from laboratory X-ray powder diffraction data with DASH: the state of the art and challenges. Journal of Applied Crystallography, 38 (2). pp. 249-259. ISSN 0021-8898

Lewis, G.R. and Steele, G. and McBride, L. and Florence, A.J. and Kennedy, A.R. and Shankland, N. and David, W.I.F. and Teat, S.J. (2005) Hydrophobic vs hydrophilic: Ionic competition in remacemide salt structures. Crystal Growth and Design, 5 (2). pp. 427-438. ISSN 1528-7483

2004

Xu, X. and Kennedy, A.R. and Florence, A.J. and Shankland, N. (2004) 4-Chlorobenzoic acid N, N-dimethylformamide solvate. Acta Crystallographica Section E: Structure Reports, 60 (11). pp. 1950-1951. ISSN 1600-5368

McConville, Jason T and Ross, A. and Chambers, A.R. and Smith, G. and Florence, A.J. and Stevens, H. (2004) The effect of wet granulation on the erosion behaviour of an HPMC-lactose tablet, used as a rate-controlling component in a pulsatile drug delivery capsule formulation. European Journal of Pharmaceutics and Biopharmaceutics, 57 (3). pp. 541-549. ISSN 0939-6411

2003

Florence, A.J. and Baumgartner, B. and Weston, C. and Shankland, N. and Kennedy, A.R. and Shankland, K. and David, W.I.F. (2003) Indexing powder patterns in physical form screening: Instrumentation and data quality. Journal of Pharmaceutical Sciences, 92 (9). pp. 1930-1938. ISSN 0022-3549

2001

Shankland, N. and David, W.I.F. and Shankland, K. and Kennedy, A.R. and Frampton, C.S. and Florence, A.J. (2001) Structural transformations in zopiclone. Chemical Communications (London), 2001 (21). pp. 2204-2205. ISSN 0009-241X

2000

Florence, A.J. and Kennedy, A.R. and Shankland, N. and Wright, E. and Al-Rubayi, A. (2000) Norfloxacin dihydrate. Acta Crystallographica Section C: Crystal Structure Communications, 56 (11). pp. 1372-1373. ISSN 0108-2701

1999

Kennedy, A.R. and Skellern, G.G. and Pfirrmann, R.W. and Smail, G.A. and Shankland, N. and Florence, A.J. (1999) Two new compounds by reaction of taurolidine with methylene glycol. Acta Crystallographica Section C: Crystal Structure Communications, 55 (2). pp. 232-234. ISSN 0108-2701