Hydrochlorothiazide N,N-dimethylacetamide disolvate

Johnston, Andrea and Florence, Alastair J. and Kennedy, Alan R. (2006) Hydrochlorothiazide N,N-dimethylacetamide disolvate. Acta Crystallographica Section E: Structure Reports, 62. O2926-O2928. ISSN 1600-5368

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Abstract

Hydrochlorothiazide forms a 1: 2 solvate with N,N-dimethylacetamide (systematic name: 6-chloro- 3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide dimethylacetamide disolvate), C(7)H(8)ClN(3)O(4)S(2)(.)2C(4)H(9)NO. The compound crystallizes with one hydrochorothiazide and two disordered solvent molecules in the asymmetric unit, with a hydrogen-bonding network comprising four N-H (...) O contacts.