Injection moulding : a novel approach to the manufacture of homogenous immediate release solid oral dosage forms

Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2016) Injection moulding : a novel approach to the manufacture of homogenous immediate release solid oral dosage forms. In: 7th APS International PharmSci Conference, 2016-09-05 - 2016-09-07, University of Strathclyde.

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    Abstract

    The current methods of dosage form production do not control the API spatial arrangement especially when using powder blends. This research aims to use Injection Moulding as a novel alternative method taking advantage of the benefits of drug-polymer interactions. Initial studies of paracetamol PVP formulations provided units that contained crystalline paracetamol due to inefficient mixing. Methods to produce solid dispersions prior to injecting such as Hot Melt Extrusions may be necessary.