XRT : Extraction of quantitative structural descriptors from solid pharmaceutical products

Doerr, Frederik J. S. and Florence, Alastair J. (2018) XRT : Extraction of quantitative structural descriptors from solid pharmaceutical products. In: Bruker Micro-CT User Meeting, 2018-04-16 - 2018-04-19.

[thumbnail of Doerr-Florence-Micro-CT-2018-Extraction-of-quantitative-structural-descriptors-from-solid-pharmaceutical-products-slides]
Text. Filename: Doerr_Florence_Micro_CT_2018_Extraction_of_quantitative_structural_descriptors_from_solid_pharmaceutical_products_slides.pdf
Download (2MB)| Preview
[thumbnail of Doerr-Florence-Micro-CT-2018-Extraction-of-quantitative-structural-descriptors-from-solid-pharmaceutical-products]
Text. Filename: Doerr_Florence_Micro_CT_2018_Extraction_of_quantitative_structural_descriptors_from_solid_pharmaceutical_products.pdf
Accepted Author Manuscript

Download (278kB)| Preview


In this project we demonstrate the use of x-ray tomography for the quantification of structural descriptors from two selected solid pharmaceutical products: single formulated particles and a commercial Ibuprofen capsule. In particular, we demonstrate the application of image processing strategies for noise reduction, image segmentation and the extraction of quantitative structural descriptors. Information on the sample’s solid state properties can be used to evaluate the manufacturing process and allows a prediction of the solid performance for subsequent processing steps or after administration to the patient.


Doerr, Frederik J. S. ORCID logoORCID: https://orcid.org/0000-0001-5245-0503 and Florence, Alastair J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364;