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2024

Matthew, Saphia A. L. and Seib, F. Philipp (2024) The dawning era of anticancer nanomedicines : from first principles to application of silk nanoparticles. Advanced Therapeutics. ISSN 2366-3987

Wang, Zhengjian and Luo, Xichun and Sun, Jining and Seib, Philipp and Phuagkhaopong, Suttinee and Xie, Wenkun and Chang, Wenlong and Liu, Qi and Chen, Xiuyuan (2024) Chip breakage in silk microfibre production using elliptical vibration turning. International Journal of Mechanical Sciences, 277. 109418. ISSN 0020-7403

Egan, Gemma and Hannah, Aiden J. and Donnelly, Sean and Connolly, Patricia and Seib, F. Philipp (2024) The biologically active biopolymer silk : the antibacterial effects of solubilised Bombyx mori silk fibroin with common wound pathogens. Advanced Biology, 8 (5). 2300115. ISSN 2701-0198

Kaewchuchuen, Jirada and Matthew, Saphia A. L. and Phuagkhaopong, Suttinee and Bimbo, Luis M. and Seib, F. Philipp (2024) Functionalising silk hydrogels with hetero- and homotypic nanoparticles. RSC Advances, 14 (5). pp. 3525-3535. ISSN 2046-2069

Matthew, Saphia A. L. and Seib, F. Philipp (2024) Silk bioconjugates : from chemistry and concept to application. ACS Biomaterials Science & Engineering, 10 (1). pp. 12-28. ISSN 2373-9878

2023

Kaewchuchuen, Jirada and Roamcharern, Napaporn and Phuagkhaopong, Suttinee and Bimbo, Luis M. and Seib, F. Philipp (2023) Microfibre-functionalised silk hydrogels. Cells, 13 (1). 10. ISSN 2073-4409

2022

Matthew, Saphia A. L. and Rezwan, Refaya and Kaewchuchuen, Jirada and Perrie, Yvonne and Seib, F. Philipp (2022) Erratum : Mixing and flow-induced nanoprecipitation for morphology control of silk fibroin self-assembly. RSC Advances, 12 (38). pp. 25006-25009. ISSN 2046-2069

Matthew, Saphia A. L. and Egan, Gemma and Witte, Kimia and Kaewchuchuen, Jirada and Phuagkhaopong, Suttinee and Totten, John D. and Seib, F. Philipp (2022) Smart silk origami as eco-sensors for environmental pollution. ACS Applied Bio Materials, 5 (8). pp. 3658-3666. ISSN 2576-6422

Matthew, Saphia A. L. and Rezwan, Refaya and Perrie, Yvonne and Seib, F. Philipp (2022) Volumetric scalability of microfluidic and semi-batch silk nanoprecipitation methods. Molecules, 27 (7). 2368. ISSN 1420-3049

Egan, Gemma and Phuagkhaopong, Suttinee and Matthew, Saphia A. L. and Connolly, Patricia and Seib, F. Philipp (2022) Impact of silk hydrogel secondary structure on hydrogel formation, silk leaching and in vitro response. Scientific Reports, 12. 3729. ISSN 2045-2322

Matthew, Saphia A. L. and Rezwan, Refaya and Kaewchuchuen, Jirada and Perrie, Yvonne and Seib, F. Philipp (2022) Mixing and flow-induced nanoprecipitation for morphology control of silk fibroin self-assembly. RSC Advances, 12 (12). pp. 7357-7373. ISSN 2046-2069

Wang, Zhengjian and Luo, Xichun and Sun, Jining and Seib, Philipp and Phuagkhaopong, Suttinee and Chang, Wenlong and Gao, Jian and Mir, Amir and Cox, Andrew (2022) Investigation of chip formation mechanism in ultra-precision diamond turning of silk fibroin film. Journal of Manufacturing Processes, 74. pp. 14-27. ISSN 1526-6125

2021

Totten, John D. and Alhadrami, Hani Abdullah and Jiffri, Essam Hussain and McMullen, Calum and Seib, F.Philipp and Carswell, Hilary V. O. (2021) Towards clinical translation of 'second-generation' regenerative stroke therapies : hydrogels as game changers? Trends in Biotechnology. ISSN 0167-7799

Gorenkova, Natalia and Maitz, Manfred F. and Böhme, Georg and Alhadrami, Hani A. and Jiffri, Essam H. and Totten, John D. and Werner, Carsten and Carswell, Hilary V. O. and Seib, F. Philipp (2021) The innate immune response of self-assembling silk fibroin hydrogels. Biomaterials Science, 9 (21). pp. 7194-7204. ISSN 2047-4830

Phuagkhaopong, Suttinee and Mendes, Luís and Müller, Katrin and Wobus, Manja and Bornhäuser, Martin and Carswell, Hilary V. O. and Duarte, Iola F. and Seib, F. Philipp (2021) Silk hydrogel substrate stress relaxation primes mesenchymal stem cell behavior in 2D. ACS Applied Materials and Interfaces, 13 (26). pp. 30420-30433. ISSN 1944-8252

Seib, F. Philipp (2021) Emerging silk material trends : repurposing, phase separation and solution-based designs. Materials, 14 (5). 1160. ISSN 1996-1944

2020

Matthew, Saphia A. L. and Totten, John D. and Phuagkhaopong, Suttinee and Egan, Gemma and Witte, Kimia and Perrie, Yvonne and Seib, F. Philipp (2020) Silk nanoparticle manufacture in semi-batch format. ACS Biomaterials Science & Engineering, 6 (12). pp. 6748-6759. ISSN 2373-9878

Newland, Ben and Varricchio, Carmine and Körner, Yvonne and Hoppe, Franziska and Taplan, Christian and Newland, Heike and Eigel, Dimitri and Tornillo, Giusy and Pette, Dagmar and Brancale, Andrea and Welzel, Petra B. and Seib, F. Philipp and Werner, Carsten (2020) Focal drug administration via heparin-containing cryogel microcarriers reduces cancer growth and metastasis. Carbohydrate Polymers, 245. 116504. ISSN 0144-8617

Solomun, Jana I. and Totten, John D. and Wongpinyochit, Thidarat and Florence, Alastair J. and Seib, F. Philipp (2020) Manual versus microfluidic-assisted nanoparticle manufacture : impact of silk fibroin stock on nanoparticle characteristics. ACS Biomaterials Science & Engineering, 6 (5). pp. 2796-2804. ISSN 2373-9878

2019

Wongpinyochit, Thidarat and Vassileiou, Antony D. and Gupta, Sukriti and Mushrif, Samir H. and Johnston, Blair F. and Seib, F. Philipp (2019) Unraveling the impact of high-order silk structures on molecular drug binding and release behaviors. Journal of Physical Chemistry Letters, 10 (15). pp. 4278-4284. ISSN 1948-7185

Wahlich, John and Desai, Arpan and Greco, Francesca and Hill, Kathryn and Jones, Arwyn T. and Mrsny, Randy and Pasut, Gianfranco and Perrie, Yvonne and Seib, F. Philipp and Seymour, Leonard W. and Uchegbu, Ijeoma F. (2019) Nanomedicines for the delivery of biologics. Pharmaceutics, 11 (5). 210. ISSN 1999-4923

Totten, John D. and Wongpinyochit, Thidarat and Carrola, Joana and Duarte, Iola F. and Seib, F. Philipp (2019) PEGylation-dependent metabolic rewiring of macrophages with silk fibroin nanoparticles. ACS Applied Materials and Interfaces, 11 (16). pp. 14515-14525. ISSN 1944-8252

Wongpinyochit, Thidarat and Totten, John D. and Johnston, Blair F. and Seib, F. Philipp (2019) Microfluidic-assisted silk nanoparticle tuning. Nanoscale Advances, 1 (2). pp. 873-883.

Holland, Chris and Numata, Keiji and Rnjak-Kovacina, Jelena and Seib, F. Philipp (2019) The biomedical use of silk : past, present, future. Advanced Healthcare Materials, 8 (1). 1800465. ISSN 2192-2640

2018

Tran, Simon H. and Wilson, Clive G. and Seib, F. Philipp (2018) A review of the emerging role of silk for the treatment of the eye. Pharmaceutical Research, 35 (12). 248. ISSN 0724-8741

Gorenkova, Natalia and Osama, Ibrahim and Seib, F. Philipp and Carswell, Hilary (2018) In vivo evaluation of engineered self-assembling silk fibroin hydrogels after intracerebral injection in a rat stroke model. ACS Biomaterials Science & Engineering. ISSN 2373-9878

Osama, I. and Gorenkova, N. and McKittrick, C.M. and Wongpinyochit, T. and Goudie, A. and Seib, F.P. and Carswell, H.V.O. (2018) In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain application. Scientific Reports, 8. 13655. ISSN 2045-2322

Brownlee, William J. and Seib, F. Philipp (2018) Impact of the hypoxia phenotype on the uptake and efflux of nanoparticles by human breast cancer cells. Scientific Reports, 8. 12318. ISSN 2045-2322

Seib, F Philipp (2018) Reverse-engineered silk hydrogels for cell and drug delivery. Therapeutic Delivery, 9 (6). pp. 469-487. ISSN 2041-5990

Newland, B. and Taplan, C. and Pette, D. and Friedrichs, J. and Steinhart, M. and Wang, W. and Voit, B. and Seib, F.P. and Werner, C. (2018) Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery. Nanoscale, 10 (18). pp. 8413-8421. ISSN 2040-3372

Seib, Philipp; Azevedo, Helena S. and da Silva, Ricardo M.P., eds. (2018) Self-assembling hydrogels from reverse-engineered silk. In: Self-assembling Biomaterials. Woodhead Publishing, Duxford, pp. 27-47. ISBN 9780081020159

Wongpinyochit, Thidarat and Johnston, Blair F. and Seib, F. Philipp (2018) Degradation behavior of silk nanoparticles – enzyme responsiveness. ACS Biomaterials Science & Engineering, 4 (3). pp. 942-951. ISSN 2373-9878

2017

Maitz, Manfred F. and Sperling, Claudia and Wongpinyochit, Thidarat and Herklotz, Manuela and Werner, Carsten and Seib, F. Philipp (2017) Biocompatibility assessment of silk nanoparticles : hemocompatibility and internalization by human blood cells. Nanomedicine: Nanotechnology, Biology and Medicine, 13 (8). pp. 2633-2642. ISSN 1549-9634

Totten, John D. and Wongpinyochit, Thidarat and Seib, F. Philipp (2017) Silk nanoparticles : proof of lysosomotropic anticancer drug delivery at single cell resolution. Journal of Drug Targeting. pp. 1-8. ISSN 1061-186X

Seib, F. Philipp; Singh, Thakur Raghu Raj and Laverty, Garry and Donnelly, Ryan, eds. (2017) Silk hydrogels for drug and cell delivery. In: Hydrogels. CRC Press, pp. 208-227. ISBN 9781498748612

Saborano, Raquel and Wongpinyochit, Thidarat and Totten, John D. and Johnston, Blair F. and Seib, Philipp and Duarte, Iola F. (2017) Metabolic reprogramming of macrophages exposed to silk, poly(lactic-co-glycolic acid) and silica nanoparticles. Advanced Healthcare Materials. ISSN 2192-2640

Seib, F. Philipp (2017) Silk nanoparticles - an emerging anticancer nanomedicine. AIMS Bioengineering, 42 (2). pp. 239-258.

2016

Seib, F. Philipp and Tsurkan, Mikhail and Freudenberg, Uwe and Kaplan, David L. and Werner, Carsten (2016) Heparin modified polyethylene glycol microparticle aggregates for focal cancer chemotherapy. ACS Biomaterials Science & Engineering, 2 (12). pp. 2287-2293.

Wongpinyochit, Thidarat and Johnston, Blair F and Seib, Philipp (2016) Manufacture and drug delivery applications of silk nanoparticles. The Journal of Visualized Experiments, 116. ISSN 1940-087X

2015

Wongpinyochit, Thidarat and Uhlmann, Petra and Urquhart, Andrew J. and Seib, F. Philipp (2015) PEGylated silk nanoparticles for anticancer drug delivery. Biomacromolecules, 16 (11). pp. 3712-3722. ISSN 1525-7797

Seib, F. Philipp and Coburn, Jeannine and Konrad, Ilona and Klebanov, Nikolai and Jones, Gregory T. and Blackwood, Brian and Charest, Alain and Kaplan, David L. and Chiu, Bill (2015) Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo. Acta Biomaterialia, 20. pp. 32-38. ISSN 1742-7061

Seib, F. Philipp and Berry, Janice E. and Shiozawa, Yusuke and Taichman, Russell S. and Kaplan, David L. (2015) Tissue engineering a surrogate niche for metastatic cancer cells. Biomaterials, 51. pp. 313-319. ISSN 1878-5905

2014

Vanterpool, Frankie A. and Cantini, Marco and Seib, F. Philipp and Salmerón-Sánchez, Manuel (2014) A material-based platform to modulate fibronectin activity and focal adhesion assembly. BioResearch Open Access, 3 (6). pp. 286-296. ISSN 2164-7860

Chiu, B and Pilichowska, M and Seib, Philipp and Charest, A and Kaplan, DL (2014) Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model. British Journal of Cancer, 111. ISSN 1532-1827

Seib, Friedrich Philipp and Herklotz, Manueal and Burke, Kelly and Maitz, Manfred and Werner, Carsten and Kaplan, David (2014) Multifunctional silk-heparin biomaterials for vascular tissue engineering applications. Biomaterials, 35 (1). pp. 83-91. ISSN 1878-5905

2013

Seib, Friedrich Philipp and Kaplan, David (2013) Silk for drug delivery applications : opportunities and challenges. Israel Journal of Chemistry, 53 (9-10). pp. 756-766. ISSN 0021-2148

Seib, Friedrich Philipp and Pritchard, Eleanor M. and Kaplan, David L. (2013) Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer. Advanced Functional Materials, 23 (1). 58–65. ISSN 1616-301X

Prewitz, Marina and Seib, F Philipp and von Bonin, Malte and Friedrichs, Jens and Stißel, Aline and Niehage, Christian and Müller, Katrin and Anastassiadis, Konstantinos and Waskow, Claudia and Hoflack, Bernard and Bornhäuser, Martin and Werner, Carsten (2013) Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nature Methods, 10 (8). 788–794. ISSN 1548-7105

Seib, F Philipp and Jones, Gregory and Rnjak-Kovacina, Jelena and Lin, Yinan and Kaplan, David L. (2013) pH-dependent anticancer drug release from silk nanoparticles. Advanced Healthcare Materials.

2012

Seib, F Philipp and Kaplan, David L (2012) Doxorubicin-loaded silk films : drug-silk interactions and in vivo performance in human orthotopic breast cancer. Biomaterials, 33 (33). pp. 8442-8450. ISSN 1878-5905

Prewitz, Marina and Seib, Friedrich Philipp and Pompe, Tilo and Werner, Carsten (2012) Polymeric biomaterials for stem cell bioengineering. Macromolecular Rapid Communications, 33 (17). pp. 1420-1431.

Reagan, Michaela R and Seib, F Philipp and McMillin, Douglas W and Sage, Elizabeth K and Mitsiades, Constantine S and Janes, Sam M and Ghobrial, Irene M and Kaplan, David L (2012) Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ. Journal of breast cancer, 15 (3). pp. 273-282.

Lescarbeau, Reynald M and Seib, F Philipp and Prewitz, Marina and Werner, Carsten and Kaplan, David L (2012) In vitro model of metastasis to bone marrow mediates prostate cancer castration resistant growth through paracrine and extracellular matrix factors. PLOS One, 7 (8). e40372.

Seib, F Philipp and Maitz, Manfred F and Werner, Carsten and Kaplan, David L (2012) Impact of processing parameters on the haemocompatibility of Bombyx mori silk films. Biomaterials, 33 (4). pp. 1017-1023. ISSN 1878-5905

2011

Sobkow, Lidia and Seib, F Philipp and Prodanov, Ljupco and Kurth, Ina and Drichel, Juliane and Bornhäuser, Martin and Werner, Carsten (2011) Prolonged transendothelial migration of human haematopoietic stem and progenitor cells (HSPCs) towards hydrogel-released SDF1. Annals of Hematology, 90 (8). pp. 865-871.

2010

Stiehler, Maik and Seib, F Philipp and Rauh, Juliane and Goedecke, Anja and Werner, Carsten and Bornhäuser, Martin and Günther, Klaus-Peter and Bernstein, Peter (2010) Cancellous bone allograft seeded with human mesenchymal stromal cells : a potential good manufacturing practice-grade tool for the regeneration of bone defects. Cytotherapy, 12 (5). pp. 658-668.

Seib, F Philipp and Lanfer, Babette and Bornhäuser, Martin and Werner, Carsten (2010) Biological activity of extracellular matrix-associated BMP-2. Journal of Tissue Engineering and Regenerative Medicine, 4 (4). pp. 324-327.

2009

Seib, F Philipp and Prewitz, Marina and Werner, Carsten and Bornhäuser, Martin (2009) Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs). Biochemical and Biophysical Research Communications, 389 (4). pp. 663-667.

Lanfer, Babette and Seib, Friedrich P and Freudenberg, Uwe and Stamov, Dimitar and Bley, Thomas and Bornhäuser, Martin and Werner, Carsten (2009) The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices. Biomaterials, 30 (30). pp. 5950-5958. ISSN 1878-5905

Seib, F Philipp and Franke, Martina and Jing, Duohui and Werner, Carsten and Bornhäuser, Martin (2009) Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells. European Journal of Cell Biology, 88 (5). pp. 257-271.

Seib, F Philipp and Müller, Katrin and Franke, Martina and Grimmer, Milauscha and Bornhäuser, Martin and Werner, Carsten (2009) Engineered extracellular matrices modulate the expression profile and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells. Tissue Engineering: Parts A, B, and C, 15 (10). pp. 3161-3171.

2008

Alberti, Kristin and Davey, Ryan E and Onishi, Kento and George, Sophia and Salchert, Katrin and Seib, F Philipp and Bornhäuser, Martin and Pompe, Tilo and Nagy, Andras and Werner, Carsten and Zandstra, Peter W (2008) Functional immobilization of signaling proteins enables control of stem cell fate. Nature Methods, 5 (7). pp. 645-650. ISSN 1548-7105

2007

Seib, F Philipp and Jones, Arwyn T and Duncan, Ruth (2007) Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells. Journal of Controlled Release, 117 (3). pp. 291-300. ISSN 0168-3659

2006

Seib, F Philipp and Jones, Arwyn T and Duncan, Ruth (2006) Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation B16F10 cells and use to study the intracellular fate of HPMA copolymer–doxorubicin. Journal of Drug Targeting, 14 (6). pp. 375-390. ISSN 1061-186X