A review of the emerging role of silk for the treatment of the eye

Tran, Simon H. and Wilson, Clive G. and Seib, F. Philipp (2018) A review of the emerging role of silk for the treatment of the eye. Pharmaceutical Research, 35 (12). 248. ISSN 0724-8741

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    Abstract

    Silk is a remarkable biopolymer with a long history of medical use. Silk fabrications have a robust track record for load-bearing applications, including surgical threads and meshes, which are clinically approved for use in humans. The progression of top-down and bottom-up engineering approaches using silk as the basis of a drug delivery or cell-loaded matrix helped to re-ignite interest in this ancient material. This review comprehensively summarises the current applications of silk for tissue engineering and drug delivery, with specific reference to the eye. Additionally, the review also covers emerging trends for the use of silk as a biologically active biopolymer for the treatment of eye disorders. The review concludes with future capabilities of silk to contribute to advanced, electronically-enhanced ocular drug delivery concepts.

    Author(s):Tran, Simon H., Wilson, Clive G. ORCID logoORCID: https://orcid.org/0000-0002-4211-7907 and Seib, F. Philipp ORCID logoORCID: https://orcid.org/0000-0002-1955-1975
    Item type:Article
    ID code:65862
    Keywords:silk fibroin, Bombyx mori, ocular, eye, tissue engineering, drug delivery, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:25 Oct 2018 12:01
    Last modified:27 Sep 2019 03:10
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/65862
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