Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ

Reagan, Michaela R and Seib, F Philipp and McMillin, Douglas W and Sage, Elizabeth K and Mitsiades, Constantine S and Janes, Sam M and Ghobrial, Irene M and Kaplan, David L (2012) Stem cell implants for cancer therapy : TRAIL-expressing mesenchymal stem cells target cancer cells in situ. Journal of breast cancer, 15 (3). pp. 273-282. (https://doi.org/10.4048/jbc.2012.15.3.273)

Abstract

Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.

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• Item metadata

  Item type:	Article
  ID code:	42105
  Dates:	Date Event September 2012 Published
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Bionanotechnology
  Depositing user:	Pure Administrator
  Date deposited:	16 Nov 2012 11:56
  Last modified:	08 Apr 2024 20:15
  URI:	https://strathprints.strath.ac.uk/id/eprint/42105