Nanomedicines for the delivery of biologics

Wahlich, John and Desai, Arpan and Greco, Francesca and Hill, Kathryn and Jones, Arwyn T. and Mrsny, Randy and Pasut, Gianfranco and Perrie, Yvonne and Seib, F. Philipp and Seymour, Leonard W. and Uchegbu, Ijeoma F. (2019) Nanomedicines for the delivery of biologics. Pharmaceutics, 11 (5). 210. ISSN 1999-4923

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    Abstract

    A special symposium of the Academy of Pharmaceutical Sciences Nanomedicines Focus Group reviewed the current status of the use of nanomedicines for the delivery of biologics drugs. This meeting was particularly timely with the recent approval of the first siRNA-containing product Onpattro™ (patisiran), which is formulated as a lipid nanoparticle for intravenous infusion, and the increasing interest in the use of nanomedicines for the oral delivery of biologics. The challenges in delivering such molecules were discussed with specific emphasis on the delivery both across and into cells. The latest developments in Molecular Envelope Technology® (Nanomerics Ltd), liposomal drug delivery (both from an academic and industrial perspective), opportunities offered by the endocytic pathway, delivery using geneticaly engineered viral vectors (PsiOxus Technologies), Transint™ technology (Applied Molecular Transport), which has the potential to deliver a wide range of macromolecules, and AstraZeneca’s initiatives in mRNA delivery were covered with a focus on their uses in difficult to treat diseases, including cancers. Preclinical data were presented for each of the technologies and where sufficiently advanced, plans for clinical studies as well as early clinical data. The meeting covered the work in progress in this exciting area and highlighted some key technologies to look out for in the future.