Atomic force microscopy studies on two-step nucleation and epitaxial growth
Warzecha, Monika and Bhardwaj, Rajni M. and Reutzel-Edens, Susan and Lamprou, Dimitrios and Florence, Alastair (2015) Atomic force microscopy studies on two-step nucleation and epitaxial growth. In: 46th BACG Annual Conference, 2015-06-21 - 2015-06-23, Queen Mary University.
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Abstract
Continues advancement and rapid development of techniques operating at the nanoscale open new opportunities to revise and question commonly accepted nucleation and crystal growth theories. Atomic Force Microscopy (AFM) has been successfully involved in various aspects of active pharmaceutical ingredient (API) characterisation including crystal growth, stability of solid dispersions, surface morphology, phase changes and dissolution [1]. Recent studies conducted on proteins crystallisation at nanoscale show new evidence disproving generally accepted Classical Nuclea/on Theory (CNT)[2]. Currently, ‘dense liquid droplets’ seen in protein crystallisation and ‘pre-nucleation clusters’ [3] seen mostly in inorganic salt crystallisation, are two main concepts of non-classical nucleation theory, although no significant progress has been made towards better understanding of mechanisms controlling heterogeneous nucleation in small organic molecules systems, what is in particular interest, as an epitaxial ordering phenomenon is frequently used to enhance nucleation rates and control properties of materials. Our studies present a new light on heteronucleation and the epitaxial growth mechanisms based epitaxial growth of olanzapine dihydrate D on the surface of olanzapine form I (OZPN I) both in high humidity conditions and water solu*on. Results obtained from Peak Force Quan/ta/ve Nanomechanical Mapping Atomic Force Microscopy (PF- QNM-AFM) [4] indicate the presence of intermediate dense liquid-like phase in process of dihydrate D nucleation.
ORCID iDs
Warzecha, Monika ORCID: https://orcid.org/0000-0001-6166-1089, Bhardwaj, Rajni M., Reutzel-Edens, Susan, Lamprou, Dimitrios ORCID: https://orcid.org/0000-0002-8740-1661 and Florence, Alastair ORCID: https://orcid.org/0000-0002-9706-8364;-
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Item type: Conference or Workshop Item(Poster) ID code: 60192 Dates: DateEvent21 June 2015PublishedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)Depositing user: Pure Administrator Date deposited: 15 Mar 2017 09:58 Last modified: 03 Sep 2024 00:33 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/60192