The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry

Cardona, Javier and Ferreira, Carla and Svoboda, Vaclav and Ahmed, Bilal and McGinty, John and Agimelen, Okpeafoh S. and Hamilton, Andrew and Cleary, Alison and Atkinson, Robert and Michie, Craig and Marshall, Stephen and Florence, Alastair J. and Chen, Yi-Chieh and Sefcik, Jan and Andonovic, Ivan and Tachtatzis, Christos (2018) The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry. In: International Conference on Manufacturing Research, 2018-09-11 - 2018-09-13.

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    Abstract

    In recent years, the pharmaceutical industry is seeing a movement towards the implementation of more efficient continuous manufacturing. This shift requires the development of in-line process analytical technologies to monitor and control the process at any given time. However, extracting reliable information from these sensors is a challenge. Among the available technologies, in-line image analysis is quickly gaining importance. This work presents an image analysis framework developed to address one of the main challenges of in-line image analysis: the presence of out-of-focus particles. Through two relevant examples such as the characterisation of a system of microparticles of mixed shapes and the monitoring of a common operation in the pharmaceutical industry such as the wet milling process, the benefits of incorporating this technique are assessed. The realtime analysis of imaging data in combination with other simultaneously-acquired quantitative data streams enables the user to make informed decisions and implement enhanced control strategies.

    Author(s):Cardona, Javier ORCID: https://orcid.org/0000-0002-9284-1899, Ferreira, Carla ORCID: https://orcid.org/0000-0002-0592-8540, Svoboda, Vaclav ORCID: https://orcid.org/0000-0002-2386-7112, Ahmed, Bilal ORCID: https://orcid.org/0000-0002-4419-8392, McGinty, John ORCID: https://orcid.org/0000-0002-8166-7266, Agimelen, Okpeafoh S. ORCID: https://orcid.org/0000-0002-0844-965X, Hamilton, Andrew ORCID: https://orcid.org/0000-0002-8436-8325, Cleary, Alison ORCID: https://orcid.org/0000-0002-3717-9812, Atkinson, Robert ORCID: https://orcid.org/0000-0002-6206-2229, Michie, Craig ORCID: https://orcid.org/0000-0001-5132-4572, Marshall, Stephen ORCID: https://orcid.org/0000-0001-7079-5628, Florence, Alastair J. ORCID: https://orcid.org/0000-0002-9706-8364, Chen, Yi-Chieh ORCID: https://orcid.org/0000-0002-8307-0666, Sefcik, Jan ORCID: https://orcid.org/0000-0002-7181-5122, Andonovic, Ivan and Tachtatzis, Christos ORCID: https://orcid.org/0000-0001-9150-6805
    Item type:Conference or Workshop Item(Paper)
    ID code:64722
    Keywords:continuous manufacturing, digitisation, in-line imaging, Manufactures, Pharmacy and materia medica, Industrial and Manufacturing Engineering, Pharmacy
    Subjects:Technology > Manufactures
    Medicine > Pharmacy and materia medica
    Department:Faculty of Engineering > Electronic and Electrical Engineering
    Faculty of Engineering > Chemical and Process Engineering
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Strategic Research Themes > Measurement Science and Enabling Technologies
    Strategic Research Themes > Advanced Manufacturing and Materials
    Depositing user: Pure Administrator
    Date deposited:09 Jul 2018 11:10
    Last modified:26 Jun 2019 04:51
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/64722
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