Mechanistic model development of α-lactose monohydrate crystallisation

Johnston, Jenna and Brown, Cameron and Florence, Alastair (2022) Mechanistic model development of α-lactose monohydrate crystallisation. In: CMAC Annual Open Day 2022, 2022-05-16 - 2022-05-18.

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The aim of this work is to develop a mechanistic model utilising the population balance modelling software gPROMS FormulatedProducts from PSE. The cooling crystallisation kinetics of alpha lactose monohydrate from water have been fitted utilising isothermal seeded desupersaturation experiments under a range of conditions following the method described by Pérez-Calvo, Kadam and Kramer[1]. The development of a robust model that accurately depicting the investigated system allows the model to be used in replacement of copious experiments for optimisation and further investigation into the behaviour of the platform.

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