Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)
Islam, M. T. and Robertson, J. and Tahir, F. and Florence, A. (2016) Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). In: 7th APS International PharmSci Conference, 2016-09-05 - 2016-09-07, University of Strathclyde.
Preview |
Text.
Filename: Islam_etal_PharmSci2016_Investigating_processing_window_of_Affinisol_and_Plasdone_S630_polymers.pdf
Accepted Author Manuscript Download (367kB)| Preview |
Preview |
Text.
Filename: Islam_etal_PharmSci2016_Poster_Investigation_of_the_processing_window_for_affinisol.pdf
Final Published Version Download (1MB)| Preview |
Abstract
There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.
ORCID iDs
Islam, M. T. ORCID: https://orcid.org/0000-0002-3530-0519, Robertson, J. ORCID: https://orcid.org/0000-0002-2191-1319, Tahir, F. and Florence, A. ORCID: https://orcid.org/0000-0002-9706-8364;-
-
Item type: Conference or Workshop Item(Poster) ID code: 56989 Dates: DateEvent7 September 2016Published13 June 2016AcceptedSubjects: Technology > Chemical technology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)Depositing user: Pure Administrator Date deposited: 19 Jul 2016 15:21 Last modified: 31 Oct 2024 01:59 URI: https://strathprints.strath.ac.uk/id/eprint/56989