Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling)

Islam, M. T. and Robertson, J. and Tahir, F. and Florence, A. (2016) Investigating processing window of Affinisol™ and Plasdone™ - S630 polymers during hot-melt extrusion (for 3D printing by fused deposition modelling). In: 7th APS International PharmSci Conference, 2016-09-05 - 2016-09-07, University of Strathclyde.

[img]
Preview
Text (Islam-etal-PharmSci2016-Investigating-processing-window-of-Affinisol™-and-Plasdone™-S630-polymers)
Islam_etal_PharmSci2016_Investigating_processing_window_of_Affinisol_and_Plasdone_S630_polymers.pdf
Accepted Author Manuscript

Download (364kB)| Preview
    [img]
    Preview
    Text (Islam-etal-PharmSci2016-Poster-Investigation-of-the-processing-window-for-affinisol)
    Islam_etal_PharmSci2016_Poster_Investigation_of_the_processing_window_for_affinisol.pdf
    Final Published Version

    Download (1MB)| Preview

      Abstract

      There are numerous polymers that have been used commercially to produce pharmaceutical solid dispersions and solutions from hot melt extrusion. Affinisol™ (HPMC) and Plasdone™ S630 (PVP based co-povidone copolymer) have been used in the present work to determine the viable processing space with regards thermal and work input on a twin screw extruder. Processing viability has been determined by monitoring degradation, initially assessed by physical appearance and colour of the extrudates across the full operating range of a twin screw extruder. It has been found that the Affinisol™ had a relatively narrow viable operating window compared with the Plasdone™.