Drug solid solutions - a method for tuning phase transformations
Delori, Amit and Maclure, Pauline and Bhardwaj, Rajni M. and Johnston, Andrea and Florence, Alastair J. and Sutcliffe, Oliver B. and Oswald, Iain D. H. (2014) Drug solid solutions - a method for tuning phase transformations. CrystEngComm, 16 (26). pp. 5827-5831. ISSN 1466-8033
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Abstract
This paper describes a methodology for the modification of phase transition temperatures using (+/-)-4 `-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.
| Creators(s): |
Delori, Amit, Maclure, Pauline  ORCID: https://orcid.org/0000-0001-6689-6725, Bhardwaj, Rajni M., Johnston, Andrea, Florence, Alastair J. ORCID: https://orcid.org/0000-0002-9706-8364, Sutcliffe, Oliver B. and Oswald, Iain D. H. ORCID: https://orcid.org/0000-0003-4339-9392;
| Item type: | Article |
|---|---|
| ID code: | 49226 |
| Keywords: | phase transition temperatures, drug solid solutions, phase transformations, Pharmacy and materia medica, Materials Science(all), Chemistry(all), Condensed Matter Physics |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC) |
| Depositing user: | Pure Administrator |
| Date deposited: | 15 Sep 2014 10:37 |
| Last modified: | 04 Sep 2020 03:21 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/49226 |
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