Drug solid solutions - a method for tuning phase transformations

Delori, Amit and Maclure, Pauline and Bhardwaj, Rajni M. and Johnston, Andrea and Florence, Alastair J. and Sutcliffe, Oliver B. and Oswald, Iain D. H. (2014) Drug solid solutions - a method for tuning phase transformations. CrystEngComm, 16 (26). pp. 5827-5831. ISSN 1466-8033

Abstract

This paper describes a methodology for the modification of phase transition temperatures using (+/-)-4 `-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.

ORCID iDs

Maclure, Pauline ORCID: https://orcid.org/0000-0001-6689-6725

Florence, Alastair J. ORCID: https://orcid.org/0000-0002-9706-8364

Oswald, Iain D. H. ORCID: https://orcid.org/0000-0003-4339-9392

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• Item metadata

  Item type:	Article
  ID code:	49226
  Dates:	Date Event 14 July 2014 Published 3 March 2014 Published Online 25 February 2014 Accepted
  Keywords:	phase transition temperatures, drug solid solutions, phase transformations, Pharmacy and materia medica, Materials Science(all), Chemistry(all), Condensed Matter Physics
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
  Depositing user:	Pure Administrator
  Date deposited:	15 Sep 2014 10:37
  Last modified:	06 Aug 2021 02:52
  URI:	https://strathprints.strath.ac.uk/id/eprint/49226