Drug solid solutions - a method for tuning phase transformations

Delori, Amit and Maclure, Pauline and Bhardwaj, Rajni M. and Johnston, Andrea and Florence, Alastair J. and Sutcliffe, Oliver B. and Oswald, Iain D. H. (2014) Drug solid solutions - a method for tuning phase transformations. CrystEngComm, 16 (26). pp. 5827-5831. ISSN 1466-8033

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Abstract

This paper describes a methodology for the modification of phase transition temperatures using (+/-)-4 `-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.

Author(s):Delori, Amit, Maclure, Pauline, Bhardwaj, Rajni M., Johnston, Andrea, Florence, Alastair J., Sutcliffe, Oliver B. and Oswald, Iain D. H.
Item type:Article
ID code:49226
Keywords:phase transition temperatures, drug solid solutions, phase transformations, Pharmacy and materia medica, Materials Science(all), Chemistry(all), Condensed Matter Physics
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Depositing user: Pure Administrator
Date deposited:15 Sep 2014 10:37
Last modified:05 Feb 2019 08:41
URI:https://strathprints.strath.ac.uk/id/eprint/49226
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