Morphological characterisation of solid pharmaceutical products using X-ray tomography

Doerr, Frederik and Brammer, Elanor and Wood, Sarahjane and Halbert, Gavin and Florence, Alastair (2017) Morphological characterisation of solid pharmaceutical products using X-ray tomography. In: Bruker micro-CT User Meeting, 2017-06-12 - 2017-06-15.

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The measurement of morphological descriptors is widely applied in the pharmaceutical industry to evaluate (intermediate) solid forms in terms of their critical quality attributes that influence product-handling in the manufacturing process or to allow a prediction of the performance of the final dosage form. Previous publications have demonstrated the use of micro-focused tomography to analyze formulations and relate the product performance to structure and sample homogeneity. The aim of this study was to assess the use of a commercial nano-focused x-ray tomography system to non-invasively investigate the three-dimensional structure of various solid pharmaceutical products. Special emphasis was given to sizing, the quantification of internal voids and the characterization of formulated samples.


Doerr, Frederik ORCID logoORCID:, Brammer, Elanor ORCID logoORCID:, Wood, Sarahjane ORCID logoORCID:, Halbert, Gavin and Florence, Alastair ORCID logoORCID:;