Engineering of acetaminophen particle attributes using a wet milling crystallisation platform

Ahmed, Bilal and Brown, Cameron J. and McGlone, Thomas and Bowering, Deborah L. and Sefcik, Jan and Florence, Alastair J. (2019) Engineering of acetaminophen particle attributes using a wet milling crystallisation platform. International Journal of Pharmaceutics, 554. pp. 201-211. ISSN 0378-5173

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    Abstract

    Wet milling coupled with crystallisation has considerable potential to deliver enhanced control over particle attributes. The effect of process conditions and wet mill configuration on particle size, shape and surface energy has been investigated on acetaminophen using a seeded cooling crystallisation coupled with a wet mill unit generating size controlled acetaminophen crystals through an interchangeable rotor-tooth configuration. The integrated wet milling crystallisation platform incorporates inline focused beam reflectance measurement (FBRM) and particle vision measurement (PVM) for in-depth understanding of particle behaviour under high-shear conditions. We used a recently developed computational tool for converting chord length distribution (CLD) from FBRM to particle size distribution (PSD) to obtain quantitative insight into the effect of the competing mechanisms of size reduction and growth in a wet milling seeded crystallisation process for acetaminophen. The novelty of our wet milling crystallisation approach is in delivery of consistent surface energies across a range of particle sizes. This highlights the potential to engineer desirable particle attributes through a carefully designed, highly intensified crystallisation process.

    Creators(s): Ahmed, Bilal ORCID logoORCID: https://orcid.org/0000-0002-4419-8392, Brown, Cameron J. ORCID logoORCID: https://orcid.org/0000-0001-7091-1721, McGlone, Thomas ORCID logoORCID: https://orcid.org/0000-0002-9897-1790, Bowering, Deborah L. ORCID logoORCID: https://orcid.org/0000-0002-8934-3469, Sefcik, Jan ORCID logoORCID: https://orcid.org/0000-0002-7181-5122 and Florence, Alastair J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364;
    Item type:Article
    ID code:65907
    Keywords:wet milling, crystallisation, breakage, CLD to PSD inversion, particle size, surface heterogeneity, Pharmacy and materia medica, Chemical Engineering(all), Pharmacology, Toxicology and Pharmaceutics(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Faculty of Engineering > Chemical and Process Engineering
    Depositing user: Pure Administrator
    Date deposited:31 Oct 2018 10:51
    Last modified:19 Feb 2020 10:37
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/65907
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