The solid state
Florence, A.J. (2009) The solid state. In: Modern pharmaceutics, Fifth Edition. Informa Healthcare, New York, USA. ISBN 9781420065657
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Many active pharmaceutical ingredients (APIs) can exist in more than one solid-state form, including crystalline polymorphs, solvates, salts, cocrystals, and noncrystalline or amorphous solids (Fig. 1; Table 1). Hence, assessment and control of the solid-state structure of APIs is necessary to ensure efficient and reproducible processing, manufacturing, and storage; to satisfy regulatory authorities; to protect intellectual property; and ultimately to deliver safe, effective, and high-quality medicinal products. This section introduces key practical aspects of solid-state pharmaceuticals, with a specific emphasis on crystalline solids and their preparation, handling, and analysis, particularly in the context of preclinical drug development and pharmaceutical manufacture.
| Author(s): | Florence, A.J.  ORCID: https://orcid.org/0000-0002-9706-8364 | Item type: | Book Section |
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| ID code: | 26060 |
| Keywords: | solid state, drug delivery, excipients, tablets, aerosols, techniques, pharmaceuticals, drug absorption, pharmacokinetics, dose forms, preformulation, optimization, systems, release, bioequivalence, processes, products, pharmaceutics, personalized medicines, evaluation, physics, in vivo imaging, biotechnology, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Strathprints Administrator |
| Date deposited: | 28 Sep 2010 13:54 |
| Last modified: | 27 Nov 2019 02:30 |
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| URI: | https://strathprints.strath.ac.uk/id/eprint/26060 |
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