Formulation of liquid propofol as a cocrystalline solid
McKellar, Scott C. and Kennedy, Alan R. and McCloy, Neil C. and McBride, Eileen and Florence, Alastair J. (2014) Formulation of liquid propofol as a cocrystalline solid. Crystal Growth and Design, 14 (5). pp. 2422-2430. ISSN 1528-7483
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This work details a crystal engineering strategy to obtain a novel solid form of the liquid drug molecule propofol using isonicotinamide as a cocrystal former. Knowledge of intermolecular hydrogen bonded supramolecular synthons has been exploited to select a potential cocrystal former based on the likely growth unit formed. The structure of the cocrystal, solved using single-crystal X-ray diffraction, is reported, confirming the molecular packing and key intermolecular interactions adopted in the novel solid form. The potential to enhance a drug’s properties is demonstrated by an increased melting point compared to the native drug form, such that the liquid drug becomes a stable solid at room temperature. Unusually, the propofol/isonicotinamide complex has three structurally similar, temperature-dependent polymorphs, and the crystal structure of each form is reported herein.
Creators(s): |
McKellar, Scott C., Kennedy, Alan R. ![]() ![]() | Item type: | Article |
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ID code: | 50867 |
Keywords: | liquid propofol, solid crystalline powder, solid drug forms, crystal structure, Chemistry, Materials Science(all), Chemistry(all), Condensed Matter Physics |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC) |
Depositing user: | Pure Administrator |
Date deposited: | 22 Dec 2014 13:22 |
Last modified: | 15 Jan 2021 04:18 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/50867 |
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