Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization

McGlone, Thomas and Briggs, Naomi E. B. and Clark, Catriona A. and Brown, Cameron J. and Sefcik, Jan and Florence, Alastair J. (2015) Oscillatory flow reactors (OFRs) for continuous manufacturing and crystallization. Organic Process Research and Development, 19 (9). 1186–1202. ISSN 1083-6160

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    Abstract

    Continuous crystallization is an attractive approach for the delivery of consistent particles with specified critical quality attributes (CQAs), which are attracting increased interest for the manufacture of high value materials, including fine chemicals and pharmaceuticals. Oscillatory flow reactors (OFRs) offer a suitable platform to deliver consistent operating conditions under plug-flow operation while maintaining a controlled steady state. This review provides a brief overview of OFR technology before outlining the operating principles and summarizing applications, emphasizing the use for controlled continuous crystallization. While significant progress has been made to date, areas for further development are highlighted that will enhance the range of applications and ease of implementation of OFR technology. These depend on specific applications but include scale down, materials of construction suitable for chemical compatibility, encrustation mitigation, the enhancement of robust operation via automation, process analytical technology (PAT), and real-time feedback control.

    Author(s):McGlone, Thomas ORCID logoORCID: https://orcid.org/0000-0002-9897-1790, Briggs, Naomi E. B., Clark, Catriona A., Brown, Cameron J. ORCID logoORCID: https://orcid.org/0000-0001-7091-1721, Sefcik, Jan ORCID logoORCID: https://orcid.org/0000-0002-7181-5122 and Florence, Alastair J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364
    Item type:Article
    ID code:54229
    Keywords:continuous crystallization, critical quality attributes, oscillatory flow reactors, process analytical technology, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Faculty of Engineering > Chemical and Process Engineering
    Technology and Innovation Centre > Bionanotechnology
    Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
    Depositing user: Pure Administrator
    Date deposited:09 Sep 2015 09:11
    Last modified:18 Oct 2019 03:53
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/54229
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