Intermolecular interactions, disorder and twinning in ciprofloxacin-2,2-difluoroethanol (2/3) and ciprofloxacin-water (3/14.5)
Fabbiani, Francesca P A and Arlin, Jean Baptiste and Buth, Gernot and Dittrich, Birger and Florence, Alastair J and Herbst-Irmer, Regine and Sowa, Heidrun (2011) Intermolecular interactions, disorder and twinning in ciprofloxacin-2,2-difluoroethanol (2/3) and ciprofloxacin-water (3/14.5). Acta Crystallographica Section C: Crystal Structure Communications, 67 (3). o120-o124.
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The antibiotic ciprofloxacin [systematic name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylate], has been crystallized as a 2:3 solvate with 2,2-difluoroethanol, 2C(17)H(18)FN(3)O(3)·3C(2)H(4)O(2), (I), and as a 3:14.5 hydrate, 3C(17)H(18)FN(3)O(3)·14.5H(2)O, (II). The structure of (I) was determined using synchrotron X-ray diffraction data and refined as a two-component nonmerohedral twin. Both structures contain several independent molecules in the asymmetric unit: (I) contains two zwitterionic ciprofloxacin molecules and three difluoroethanol solvent molecules, while (II) contains three zwitterionic ciprofloxacin molecules and a mixture of ordered and disordered water molecules. The intermolecular interactions were analysed using fingerprint plots derived from Hirshfeld surfaces, providing a detailed description of the unique environment of each independent ciprofloxacin molecule.
| Author(s): | Fabbiani, Francesca P A, Arlin, Jean Baptiste, Buth, Gernot, Dittrich, Birger, Florence, Alastair J  ORCID: https://orcid.org/0000-0002-9706-8364, Herbst-Irmer, Regine and Sowa, Heidrun | Item type: | Article |
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| ID code: | 33064 |
| Keywords: | anti-bacterial agents, ciprofloxacin, crystallography, X-ray, hydrogen bonding, isoquinolines, molecular structure, piperazines, water, X-ray diffraction, Pharmacy and materia medica, Biochemistry, Genetics and Molecular Biology(all) |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC) |
| Depositing user: | Pure Administrator |
| Date deposited: | 30 Aug 2011 12:57 |
| Last modified: | 17 Jan 2020 07:12 |
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| URI: | https://strathprints.strath.ac.uk/id/eprint/33064 |
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