Intermolecular interactions, disorder and twinning in ciprofloxacin-2,2-difluoroethanol (2/3) and ciprofloxacin-water (3/14.5)

Fabbiani, Francesca P A and Arlin, Jean Baptiste and Buth, Gernot and Dittrich, Birger and Florence, Alastair J and Herbst-Irmer, Regine and Sowa, Heidrun (2011) Intermolecular interactions, disorder and twinning in ciprofloxacin-2,2-difluoroethanol (2/3) and ciprofloxacin-water (3/14.5). Acta Crystallographica Section C: Crystal Structure Communications, 67 (3). o120-o124.

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Abstract

The antibiotic ciprofloxacin [systematic name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-4-ium-1-yl)-1,4-dihydroquinoline-3-carboxylate], has been crystallized as a 2:3 solvate with 2,2-difluoroethanol, 2C(17)H(18)FN(3)O(3)·3C(2)H(4)O(2), (I), and as a 3:14.5 hydrate, 3C(17)H(18)FN(3)O(3)·14.5H(2)O, (II). The structure of (I) was determined using synchrotron X-ray diffraction data and refined as a two-component nonmerohedral twin. Both structures contain several independent molecules in the asymmetric unit: (I) contains two zwitterionic ciprofloxacin molecules and three difluoroethanol solvent molecules, while (II) contains three zwitterionic ciprofloxacin molecules and a mixture of ordered and disordered water molecules. The intermolecular interactions were analysed using fingerprint plots derived from Hirshfeld surfaces, providing a detailed description of the unique environment of each independent ciprofloxacin molecule.

Creators(s): Fabbiani, Francesca P A, Arlin, Jean Baptiste, Buth, Gernot, Dittrich, Birger, Florence, Alastair J ORCID logoORCID: https://orcid.org/0000-0002-9706-8364, Herbst-Irmer, Regine and Sowa, Heidrun;
Item type:Article
ID code:33064
Keywords:anti-bacterial agents, ciprofloxacin, crystallography, X-ray, hydrogen bonding, isoquinolines, molecular structure, piperazines, water, X-ray diffraction, Pharmacy and materia medica, Biochemistry, Genetics and Molecular Biology(all)
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Depositing user: Pure Administrator
Date deposited:30 Aug 2011 12:57
Last modified:01 Sep 2020 02:50
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URI:https://strathprints.strath.ac.uk/id/eprint/33064
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