Rapid continuous antisolvent crystallization of multi-component systems

Raza, Syed A. and Schacht, Ulrich and Svoboda, Vaclav and Edwards, Darren P. and Florence, Alastair J. and Pulham, Colin R. and Sefcik, Jan and Oswald, Iain D. H. (2018) Rapid continuous antisolvent crystallization of multi-component systems. Crystal Growth and Design, 18 (1). pp. 210-218. ISSN 1528-7483

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    Abstract

    This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising L-leucine, L-isoleucine and L-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ball-milling, liquid-assisted grinding and slurry methods, to achieve required multi-component solid phases. We report new crystal structures of L-leucine:L-isoleucine and L-leucine:L-valine, and confirm a recent report on a new form of L-isoleucine:L-valine. We used these multi-component complexes as a test set of materials to demonstrate translation of small scale batch antisolvent crystallization to a continuous production process.

    Author(s):Raza, Syed A., Schacht, Ulrich, Svoboda, Vaclav ORCID logoORCID: https://orcid.org/0000-0002-2386-7112, Edwards, Darren P. ORCID logoORCID: https://orcid.org/0000-0001-9544-8569, Florence, Alastair J. ORCID logoORCID: https://orcid.org/0000-0002-9706-8364, Pulham, Colin R., Sefcik, Jan ORCID logoORCID: https://orcid.org/0000-0002-7181-5122 and Oswald, Iain D. H. ORCID logoORCID: https://orcid.org/0000-0003-4339-9392
    Item type:Article
    ID code:62736
    Keywords:antisolvent crystallization, crystal structures, crystallization, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Faculty of Engineering > Chemical and Process Engineering
    Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
    Strategic Research Themes > Advanced Manufacturing and Materials
    Technology and Innovation Centre > Bionanotechnology
    Depositing user: Pure Administrator
    Date deposited:08 Jan 2018 11:18
    Last modified:17 Aug 2019 00:42
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/62736
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