Rapid continuous antisolvent crystallization of multi-component systems
Raza, Syed A. and Schacht, Ulrich and Svoboda, Vaclav and Edwards, Darren P. and Florence, Alastair J. and Pulham, Colin R. and Sefcik, Jan and Oswald, Iain D. H. (2018) Rapid continuous antisolvent crystallization of multi-component systems. Crystal Growth and Design, 18 (1). pp. 210-218. ISSN 1528-7483
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Abstract
This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising L-leucine, L-isoleucine and L-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ball-milling, liquid-assisted grinding and slurry methods, to achieve required multi-component solid phases. We report new crystal structures of L-leucine:L-isoleucine and L-leucine:L-valine, and confirm a recent report on a new form of L-isoleucine:L-valine. We used these multi-component complexes as a test set of materials to demonstrate translation of small scale batch antisolvent crystallization to a continuous production process.
ORCID iDs
Raza, Syed A., Schacht, Ulrich, Svoboda, Vaclav




Item type: Article ID code: 62736 Dates: DateEvent3 January 2018Published27 November 2017Published Online27 November 2017AcceptedKeywords: antisolvent crystallization, crystal structures, crystallization, Chemistry, Chemistry(all) Subjects: Science > Chemistry Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Engineering > Chemical and Process Engineering
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
Strategic Research Themes > Advanced Manufacturing and Materials
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 08 Jan 2018 11:18 Last modified: 11 Apr 2021 00:44 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/62736