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Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

Fabbiani, Francesca P.A. and Dittrich, Birger and Florence, A.J. and Gelbrich, T. and Hursthouse, M.B. and Kuhs, Werner F. and Shankland, N. and Sowa, Heidrum (2008) Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure. CrystEngComm, 11. pp. 1396-1406. ISSN 1466-8033

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Abstract

Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25 and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first reported examples of ciprofloxacin chelating a Group IA monovalent cation. Ambient-pressure crystallisation of the same solution used for high-pressure experiments, yielded crystals of the known hexahydrate. In a parallel study, the previously unknown structure of anhydrous ciprofloxacin was determined from powder diffraction data. The structures are described and compared using the XPac method.

Item type:Article
ID code:13148
Keywords:crystal structures, high-pressure crystallisation, ciprofloxacin sodium salts, ambient pressure, biomedical sciences, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Materials Science(all), Chemistry(all), Condensed Matter Physics
Subjects:Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Pharmaceutical Sciences
Depositing user: Ms Ann Barker-Myles
Date deposited:05 Oct 2009 14:33
Last modified:14 Jun 2019 02:19
URI:https://strathprints.strath.ac.uk/id/eprint/13148
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