Enabling model-predictive design : rapid development of a PBM for an anti-solvent and cooling crystallisation in two different reactor geometries

Ojo, E. and Siddique, H. and Houson, I. and Brown, C. and O'Meahdra, R. and Berthold, S. and Florence, A. (2019) Enabling model-predictive design : rapid development of a PBM for an anti-solvent and cooling crystallisation in two different reactor geometries. In: American Association of Pharmaceutical Scientists PharmSci 360, 2019, 2019-11-03 - 2019-11-07.

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Abstract

The study aimed to develop a rapid model using gProms Formulated Products for a proprietary single polymorph active pharmaceutical ingredient (API) crystallisation at small scale for early process understanding. The model outcomes are then later used to inform the experimental design of continuous crystallisation for multi-addition antisolvent and cooling crystallization in both continuous oscillatory baffled reactor (COBC) and mixed-suspension and mixed- product removal (MSMPR) crystalliser

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• Item metadata

  Item type:	Conference or Workshop Item(Poster)
  ID code:	77206
  Dates:	Date Event 3 November 2019 Published
  Subjects:	Medicine > Pharmacy and materia medica
  Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Strategic Research Themes > Advanced Manufacturing and Materials Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
  Depositing user:	Pure Administrator
  Date deposited:	29 Jul 2021 09:51
  Last modified:	11 Apr 2024 03:12
  URI:	https://strathprints.strath.ac.uk/id/eprint/77206