Isomorphous template induced crystallisation : a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

Srirambhatla, Vijay and Guo, Rui and Price, Sarah L. and Florence, Alastair James (2016) Isomorphous template induced crystallisation : a robust method for the targeted crystallisation of computationally predicted metastable polymorphs. Chemical Communications, 52 (46). pp. 7384-7386. ISSN 1359-7345

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    Abstract

    A new method of inducing the crystallisation of metastable polymorphs by isomorphous templating has been developed and used to reproduce the crystallisation of CBZ-V on the surface of DHC-II. Studies of the growth of CBZ-V on DHC-II single crystals show crystals growing laterally and vertically on DHC-II surfaces without any significant face selectivity. The generality of this computationally inspired crystallisation approach is demonstrated by producing the first crystals of an entirely new polymorph of cyheptamide, which is isomorphous to both DHC-II and CBZ-V.

    Creators(s): Srirambhatla, Vijay ORCID logoORCID: https://orcid.org/0000-0002-4492-7567, Guo, Rui, Price, Sarah L. and Florence, Alastair James ORCID logoORCID: https://orcid.org/0000-0002-9706-8364;
    Item type:Article
    ID code:56443
    Keywords:crystallisation, growing crystals, polymorphs, Chemistry, Chemistry(all)
    Subjects:Science > Chemistry
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)
    Depositing user: Pure Administrator
    Date deposited:19 May 2016 13:29
    Last modified:21 Jan 2021 00:13
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/56443
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