Properties of packed bed structures formed during filtration : a two and three-dimensional model

Eales, William and Price, Chris J. and Hicks, William and Mulheran, Paul A. (2023) Properties of packed bed structures formed during filtration : a two and three-dimensional model. Organic Process Research and Development, 27 (9). pp. 1631-1640. ISSN 1083-6160 (https://doi.org/10.1021/acs.oprd.3c00147)

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Abstract

Agglomeration is an issue that causes many problems during secondary processing for pharmaceutical companies, causing material to need further processing and costing additional time and resources to ensure a satisfactory outcome. A potential source of agglomeration arises from the particle contacts established during filtration that lead to robust agglomerates forming during drying, so that a necessary first step toward understanding agglomeration is to study the packing properties of filtration beds. Here, we present two and three-dimensional models simulating the formation of packed bed structures during filtration. The models use circular and spherical particles of different sizes, mimicking the bimodal particle size distributions sometimes encountered in industrial practice. The statistics of packing and void formation, along with the distribution of interparticle contacts and percolation structures, are presented and discussed in the context of filtration, drying, and agglomeration. The model paves the way for predictive capabilities that can lead to the rational design of processes to minimize the impact of agglomeration.

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