Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing : a case study using paracetamol

Ottoboni, S. and Price, C. J. and Steven, C. and Meehan, E. and Barton, A. and Mitchell, A. (2016) Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing : a case study using paracetamol. In: Filtech, 2016-10-11 - 2016-10-13, Koelnmesse.

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Abstract

The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.

ORCID iDs

Ottoboni, S. ORCID logoORCID: https://orcid.org/0000-0002-2792-3011, Price, C. J., Steven, C. ORCID logoORCID: https://orcid.org/0000-0002-6784-7244, Meehan, E., Barton, A. and Mitchell, A.;