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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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A general method for the α-acyloxylation of carbonyl compounds

Beshara, Cory S. and Hall, Adrian and Jenkins, Robert L. and Jones, Kerri L. and Jones, Teyrnon C. and Killeen, Niall M. and Taylor, Paul H. and Thomas, Stephen P. and Tomkinson, Nicholas C. O. (2005) A general method for the α-acyloxylation of carbonyl compounds. Organic Letters, 7 (25). pp. 5729-5732. ISSN 1523-7060

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Abstract

A simple, one-pot method for the α-acyloxylation of carbonyl compds. that proceeded at room temp. in the presence of both moisture and air has been developed. Treatment of a variety of aldehydes and both cyclic and acyclic ketones with N-methyl-O-benzoylhydroxylamine hydrochloride provided the α-functionalized product in good isolated yield. The transformation was tolerant of a wide range of functional groups and, significantly, was regiospecific in the discrimination of secondary over primary centers in the case of nonsym. substrates.