A regioselective three component reaction of pyridine N-oxides, acyl chlorides and cyclic ethers
Jones, D. Heulyn and Kay, Steven T. and McLellan, Jayde A. and Kennedy, Alan R. and Tomkinson, Nicholas C. O. (2017) A regioselective three component reaction of pyridine N-oxides, acyl chlorides and cyclic ethers. Organic Letters. ISSN 1523-7060
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Official URL: https://doi.org/10.1021/acs.orglett.7b01481
Abstract
A novel 3-component reaction of pyridine N-oxides, acyl chlorides and cyclic ethers is described. Treatment of an electron defi-cient pyridine N-oxide with an acyl chloride in the presence of a cyclic ether at 25–50 °C leads to a substituted pyridine as a single regioisomer in up to 58% isolated yield. Isotopic labelling experiments and substrate scope support the reaction proceeding through a carbene intermediate.
Creators(s): |
Jones, D. Heulyn, Kay, Steven T. ![]() ![]() ![]() ![]() | Item type: | Article |
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ID code: | 61128 |
Keywords: | acyl chloride, pyridine N-oxides, cyclic ethers, Chemistry, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 28 Jun 2017 10:26 |
Last modified: | 22 Feb 2021 02:39 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/61128 |
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