Synthesis, characterisation and multi-modal intracellular mapping of cisplatin nano-conjugates

Leventi, Aristea Anna and Braddick, Henry J. and Billimoria, Kharmen and Wallace, Gregory Q. and Goenaga-Infante, Heidi and Tomkinson, Nicholas C.O. and Faulds, Karen and Graham, Duncan (2023) Synthesis, characterisation and multi-modal intracellular mapping of cisplatin nano-conjugates. Chemical Communications, 59 (42). pp. 6395-6398. ISSN 1359-7345 (https://doi.org/10.1039/d3cc00925d)

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Abstract

The synthesis of nanocarriers for the delivery of the antitumor drug cisplatin is reported. Multimodal-imaging consisting of surface enhanced Raman scattering and laser ablation inductively coupled plasma time of flight mass spectrometry was used to visualise the intracellular uptake of both the nanocarrier and drug.

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