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Differential activity of rosiglitazone enantiomers at PPARγ

Parks, Derek J. and Tomkinson, Nicholas C. O. and Villeneuve, Manon S. and Blanchard, Steven G. and Willson, Timothy M. (1998) Differential activity of rosiglitazone enantiomers at PPARγ. Bioorganic and Medicinal Chemistry Letters, 8 (24). pp. 3657-3658. ISSN 0960-894X

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Abstract

Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.

Item type: Article
ID code: 34216
Keywords: rosiglitazone enantiomers , rosiglitazone , antidiabetic activity, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Depositing user: Pure Administrator
Date deposited: 20 Oct 2011 15:22
Last modified: 22 Mar 2017 11:42
URI: https://strathprints.strath.ac.uk/id/eprint/34216
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