Differential activity of rosiglitazone enantiomers at PPARγ

Parks, Derek J. and Tomkinson, Nicholas C. O. and Villeneuve, Manon S. and Blanchard, Steven G. and Willson, Timothy M. (1998) Differential activity of rosiglitazone enantiomers at PPARγ. Bioorganic and Medicinal Chemistry Letters, 8 (24). pp. 3657-3658. ISSN 0960-894X

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Abstract

Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.

ORCID iDs

Parks, Derek J., Tomkinson, Nicholas C. O. ORCID logoORCID: https://orcid.org/0000-0002-5509-0133, Villeneuve, Manon S., Blanchard, Steven G. and Willson, Timothy M.;
  • Item type:Article
    ID code:34216
    Dates:
    Date
    Event
    1998
    Published
    Keywords:rosiglitazone enantiomers , rosiglitazone , antidiabetic activity, Chemistry, Biochemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Clinical Biochemistry
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:20 Oct 2011 15:22
    Last modified:27 Aug 2021 03:08
    URI:https://strathprints.strath.ac.uk/id/eprint/34216
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