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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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A novel deprotection/functionalization sequence using 2,4-dinitrobenzenesulfonamide: Part 1

Messeri, Tommaso and Sternbach, Daniel D. and Tomkinson, Nicholas C. O. (1998) A novel deprotection/functionalization sequence using 2,4-dinitrobenzenesulfonamide: Part 1. Tetrahedron Letters, 39 (13). pp. 1669-1672. ISSN 0040-4039

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Abstract

Treatment of R1R2SO2C6H3(NO2)2-2,4 [R1 = 4-MeOC6H4CH2, R2 = H, CH2CH2OMe, allyl; R1 = 3,4-methylenedioxyphenyl, R2 = H, CH2CH2OMe] with R3COSH [R3 = Me, Ph, CF3, CMe3, 2-imidazolyl] in the presence of cesium carbonate gave R1R2NCOR3 in 81-96% yield.