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2024

Hryczanek, Ross P. and Hackett, Andrew S. and Rowland, Paul and Chung, Chun-wa and Convery, Máire A. and Holmes, Duncan S. and Hutchinson, Jonathan P. and Kitchen, Semra and Korczynska, Justyna and Law, Robert P. and Lea, Jonatahn D. and Liddle, John and Lonsdale, Richard and Neu, Margarete and Nickels, Leng and Phillipou, Alex and Rowedder, James E. and Schneck, Jessica L. and Scott-Stevens, Paul and Sheehan, Hester and Tayler, Chloe L. and Temponeras, Ioannis and Tinworth, Christopher P. and Walker, Ann L. and Wojno-Picon, Justyna and Young, Robert J. and Lindsay, David M. and Stratikos, Efstratios (2024) Optimization of potent and selective cyclohexyl acid ERAP1 inhibitors using structure- and property-based drug design. ACS Medicinal Chemistry Letters, 15 (12). 2107–2114. ISSN 1948-5875

2023

Henry, Martyn C. and Riley, Christopher M. and Hunter, Irene and Elwood, Jessica. M. L. and Lopez-Fernandez, J. Daniel and Minty, Laura and Coe, Diane M. and McEwan, Iain J. and Jamieson, Craig (2023) Synthesis and evaluation of small molecule inhibitors of the androgen receptor N-terminal domain. ACS Medicinal Chemistry Letters, 14 (12). pp. 1800-1806. ISSN 1948-5875

2021

Clegg, Michael A. and Theodoulou, Natalie H. and Bamborough, Paul and Chung, Chun-wa and Craggs, Peter D. and Demont, Emmanuel H. and Gordon, Laurie J. and Liwicki, Gemma M. and Phillipou, Alex and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2021) Optimization of naphthyridones into selective TATA-binding protein associated factor 1 (TAF1) bromodomain inhibitors. ACS Medicinal Chemistry Letters, 12 (8). pp. 1308-1317. ISSN 1948-5875

2020

Spencer, Jonathan A. and Baldwin, Ian R. and Barton, Nick and Chung, Chun-Wa and Convery, Máire A. and Edwards, Christopher D. and Jamieson, Craig and Mallett, David N. and Rowedder, James E. and Rowland, Paul and Thomas, Daniel A. and Hardy, Charlotte J. (2020) Design and development of a macrocyclic series targeting phosphoinositide 3-kinase δ. ACS Medicinal Chemistry Letters, 11 (7). pp. 1386-1391. ISSN 1948-5875

2018

Ahonen, Tiina J. and Savinainen, Juha R. and Yli-Kauhaluoma, Jari and Kalso, Eija and Laitinen, Jarmo T. and Moreira, Vânia M. (2018) Discovery of 12-thiazole abietanes as selective inhibitors of the human metabolic serine hydrolase hABHD16A. ACS Medicinal Chemistry Letters, 9 (12). pp. 1269-1273. ISSN 1948-5875

2016

Measom, Nicholas and Down, Kenneth D. and Hirst, David J. and Jamieson, Craig and Manas, Eric S. and Patel, Vipulkumar K. and Somers, Donald O. (2016) Investigation of a bicyclo[1.1.1]pentane as a phenyl replacement within an LpPLA2 inhibitor. ACS Medicinal Chemistry Letters, 7.

2015

Caldwell, Nicola and Harms, Jonathan E. and Partin, Kathryn M. and Jamieson, Craig (2015) Rational design of a novel AMPA receptor modulator through a hybridization approach. ACS Medicinal Chemistry Letters.