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2022

Humphreys, Philip G. and Atkinson, Stephen J. and Bamborough, Paul and Bit, Rino A. and Chung, Chun-wa and Craggs, Peter D. and Cutler, Leanne and Davis, Rob and Ferrie, Alan and Gong, GangLi and Gordon, Laurie J. and Gray, Matthew and Harrison, Lee A. and Hayhow, Thomas G. and Haynes, Andrea and Henley, Nick and Hirst, David J. and Holyer, Ian D. and Lindon, Matthew J. and Lovatt, Cerys and Lugo, David and McCleary, Scott and Molnar, Judit and Osmani, Qendresa and Patten, Chris and Preston, Alex and Rioja, Inmaculada and Seal, Jonathan T. and Smithers, Nicholas and Sun, Fenglai and Tang, Dalin and Taylor, Simon and Theodoulou, Natalie H. and Thomas, Clare and Watson, Robert J. and Wellaway, Christopher R. and Zhu, Linrong and Tomkinson, Nicholas C. O. and Prinjha, Rab K. (2022) Design, synthesis, and characterization of I-BET567, a pan-bromodomain and extra terminal (BET) bromodomain oral candidate. Journal of Medicinal Chemistry, 65 (3). pp. 2262-2287. ISSN 0022-2623

2021

Clegg, Michael A. and Theodoulou, Natalie H. and Bamborough, Paul and Chung, Chun-wa and Craggs, Peter D. and Demont, Emmanuel H. and Gordon, Laurie J. and Liwicki, Gemma M. and Phillipou, Alex and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2021) Optimization of naphthyridones into selective TATA-binding protein associated factor 1 (TAF1) bromodomain inhibitors. ACS Medicinal Chemistry Letters, 12 (8). pp. 1308-1317. ISSN 1948-5875

2020

Clegg, Michael A. and Bamborough, Paul and Chung, Chun-wa and Craggs, Peter D. and Gordon, Laurue and Grandi, Paola and Leveridge, Melanie and Lindon, Matthew and Liwicki, Gemma M. and Michon, Anne-Marie and Molnar, Judit and Rioja, Inmaculada and Soden, Peter E. and Theodoulou, Natalie H. and Werner, Thilo and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2020) Application of atypical acetyl-lysine methyl mimetics in the development of selective inhibitors of the bromodomain-containing protein 7 (BRD7)/bromodomain-containing protein 9 (BRD9) bromodomains. Journal of Medicinal Chemistry, 63 (11). pp. 5816-5840. ISSN 0022-2623

2016

Theodoulou, Natalie H. and Tomkinson, Nicholas C. O. and Prinjha, Rab K. and Humphreys, Philip G. (2016) Progress in the development of non-​BET bromodomain chemical probes. ChemMedChem, 11 (5). pp. 477-487. ISSN 1860-7179

Theodoulou, Natalie H. and Bamborough, Paul and Bannister, Andrew J. and Becher, Isabelle and Bit, Rino A. and Che, Ka Hing and Chung, Chun-wa and Dittmann, Antje and Drewes, Gerard and Drewy, David H. and Gordon, Laurie and Grandi, Paola and Leveridge, Melanie and Lindon, Matthew and Michon, Anne-Marie and Molnar, Judit and Robson, Samuel C. and Tomkinson, Nicholas C. O. and Kouzarides, Tony and Prinjha, Rab K. and Humphreys, Philip G. (2016) The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. Journal of Medicinal Chemistry, 59 (4). pp. 1425-1439. ISSN 0022-2623

2015

Alamillo-Ferrer, Carla and Davidson, Stuart C. and Rawling, Michael J. and Theodoulou, Natalie H. and Campbell, Matthew and Humphreys, Philip G. and Kennedy, Alan R. and Tomkinson, Nicholas C. O. (2015) Alkene anti-dihydroxylation with malonoyl peroxides. Organic Letters, 17 (20). pp. 5132-5135. ISSN 1523-7060