A mild and efficient method for the one-pot monocarboxymethylation of primary amines

Gibbs, Timothy J. K. and Boomhoff, Michael and Tomkinson, Nicholas C. O. (2007) A mild and efficient method for the one-pot monocarboxymethylation of primary amines. Synlett (10). pp. 1573-1576. ISSN 0936-5214

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Abstract

A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield.

ORCID iDs

Gibbs, Timothy J. K., Boomhoff, Michael and Tomkinson, Nicholas C. O. ORCID logoORCID: https://orcid.org/0000-0002-5509-0133;