A mild and efficient method for the one-pot monocarboxymethylation of primary amines
Gibbs, Timothy J. K. and Boomhoff, Michael and Tomkinson, Nicholas C. O. (2007) A mild and efficient method for the one-pot monocarboxymethylation of primary amines. Synlett (10). pp. 1573-1576. ISSN 0936-5214 (https://doi.org/10.1055/s-2007-982531)
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A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield.
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Item type: Article ID code: 34180 Dates: DateEvent2007PublishedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 20 Oct 2011 13:50 Last modified: 08 Apr 2024 19:29 URI: https://strathprints.strath.ac.uk/id/eprint/34180
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