Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands.

Tomkinson, Nicholas C. O. and Sefler, Andrea M. and Plunket, Kelli D. and Blanchard, Steven G. and Parks, Derek J. and Willson, Timothy M. (1997) Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands. Bioorganic and Medicinal Chemistry Letters, 7 (19). pp. 2491-2496. ISSN 0960-894X

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Abstract

A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.