A public-private partnership to unlock the untargeted kinome

Knapp, Stefan and Arruda, Paulo and Blagg, Julian and Burley, Stephen and Drewery, David and Edwards, Aled and Fabbro, Doriano and Gillespie, Paul and Gray, Nathanael S and Kuster, Bernhard and Lackey, Karen E and Mazzafera, Paulo and Tomkinson, Nick and Willson, Timothy and Workman, Paul and Zuercher, William (2013) A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology, 9 (1). pp. 3-6. ISSN 1552-4450 (https://doi.org/10.1038/nchembio.1113)

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Chemical probes are urgently needed to functionally annotate hitherto untargeted kinases and stimulate new drug discovery efforts to address unmet medical need. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large scale public-private partnership as a new approach which offers economies of scale, minimized redundancy, and sharing of risk and cost.