Improving catalyst activity in secondary amine catalysed transformations
Brazier, John B. and Gibbs, Timothy J. K. and Rowley, Julian H. and Samulis, Leopold and Yau, Sze Chak and Kennedy, Alan R. and Platts, James A. and Tomkinson, Nicholas C. O. (2015) Improving catalyst activity in secondary amine catalysed transformations. Organic and Biomolecular Chemistry, 13 (1). pp. 133-141. ISSN 1477-0520 (https://doi.org/10.1039/C4OB01916D)
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Abstract
The effect on catalyst performance of altering substituents at the 2-position of the Macmillan imidazolidinone has been examined. Condensation of L-phenylalanine N-methyl amide with acetophenone derivatives results in a series of imidazolidinones whose salts can be used to accelerate the Diels-Alder cycloaddition. Electron withdrawing groups significantly increases the overall rate of cycloaddition without compromise in selectivity. The most effective catalyst was shown to be efficient for a variety of substrates and the applicability of this catalyst to alternative secondary amine catalysed transformations is also discussed.
ORCID iDs
Brazier, John B., Gibbs, Timothy J. K., Rowley, Julian H., Samulis, Leopold, Yau, Sze Chak, Kennedy, Alan R. ORCID: https://orcid.org/0000-0003-3652-6015, Platts, James A. and Tomkinson, Nicholas C. O. ORCID: https://orcid.org/0000-0002-5509-0133;-
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Item type: Article ID code: 56149 Dates: DateEvent7 January 2015Published14 October 2014Published Online14 October 2014AcceptedSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 14 Apr 2016 10:15 Last modified: 12 Sep 2024 00:41 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/56149