A simple method for the preparation of di-, tri-, and tetrasubstituted non-symmetrical ureas

Bridgeman, Eve and Tomkinson, Nicholas C. O. (2006) A simple method for the preparation of di-, tri-, and tetrasubstituted non-symmetrical ureas. Synlett (2). pp. 243-246. ISSN 0936-5214 (https://doi.org/10.1055/s-2005-923584)

Abstract

The synthesis of a series of di-, tri-, and tetrasubstituted non-sym. ureas is described. Di- and trisubstituted ureas are prepd. in excellent yield by treatment of a Ph carbamate in a self-tunable single-mode microwave synthesizer with a primary or secondary amine. The synthetically more challenging tetrasubstituted urea can be prepd. using the 4-nitrophenyl carbamate and a secondary amine.

ORCID iDs

Tomkinson, Nicholas C. O. ORCID: https://orcid.org/0000-0002-5509-0133

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  Item type:	Article
  ID code:	34190
  Dates:	Date Event 2006 Published
  Keywords:	urea , carbamate , microwave-assisted synthesis , Chemistry, Organic Chemistry
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	20 Oct 2011 14:04
  Last modified:	20 Jan 2021 19:38
  URI:	https://strathprints.strath.ac.uk/id/eprint/34190