A simple method for the preparation of di-, tri-, and tetrasubstituted non-symmetrical ureas

Bridgeman, Eve and Tomkinson, Nicholas C. O. (2006) A simple method for the preparation of di-, tri-, and tetrasubstituted non-symmetrical ureas. Synlett (2). pp. 243-246. ISSN 0936-5214

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Abstract

The synthesis of a series of di-, tri-, and tetrasubstituted non-sym. ureas is described. Di- and trisubstituted ureas are prepd. in excellent yield by treatment of a Ph carbamate in a self-tunable single-mode microwave synthesizer with a primary or secondary amine. The synthetically more challenging tetrasubstituted urea can be prepd. using the 4-nitrophenyl carbamate and a secondary amine.