Preparation of the MacMillan Imidazolidinones

Samulis, Leopold and Tomkinson, Nicholas C.O. (2011) Preparation of the MacMillan Imidazolidinones. Tetrahedron, 67 (23). pp. 4263-4267. ISSN 0040-4020 (

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A general method for the preparation of the MacMillan imidazolidinones is described. Treatment of an α-amino amide with a carbonyl compound in refluxing chloroform in the presence of Yb(OTf)3 (1 mol%) provides convenient access to the corresponding imidazolidinones


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